Entity Details

Primary name ACACB_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionO00763
EntryNameACACB_HUMAN
FullNameAcetyl-CoA carboxylase 2
TaxID9606
Evidenceevidence at protein level
Length2458
SequenceStatuscomplete
DateCreated1997-11-01
DateModified2021-06-02

Ontological Relatives

GenesACACB

GO terms

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GOName
GO:0003989 acetyl-CoA carboxylase activity
GO:0005524 ATP binding
GO:0005634 nucleus
GO:0005739 mitochondrion
GO:0005741 mitochondrial outer membrane
GO:0005829 cytosol
GO:0006084 acetyl-CoA metabolic process
GO:0006633 fatty acid biosynthetic process
GO:0006853 carnitine shuttle
GO:0009374 biotin binding
GO:0010629 negative regulation of gene expression
GO:0010884 positive regulation of lipid storage
GO:0010906 regulation of glucose metabolic process
GO:0014070 response to organic cyclic compound
GO:0019216 regulation of lipid metabolic process
GO:0031325 positive regulation of cellular metabolic process
GO:0031667 response to nutrient levels
GO:0031999 negative regulation of fatty acid beta-oxidation
GO:0042493 response to drug
GO:0042802 identical protein binding
GO:0043086 negative regulation of catalytic activity
GO:0046872 metal ion binding
GO:0051289 protein homotetramerization
GO:0060421 positive regulation of heart growth
GO:0097009 energy homeostasis
GO:2001295 malonyl-CoA biosynthetic process

Subcellular Location

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Subcellular Location
Mitochondrion

Domains

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DomainNameCategoryType
IPR000089 Biotin/lipoyl attachmentDomainDomain
IPR005479 Carbamoyl-phosphate synthetase large subunit-like, ATP-binding domainDomainDomain
IPR005481 Biotin carboxylase-like, N-terminal domainDomainDomain
IPR005482 Biotin carboxylase, C-terminalDomainDomain
IPR011053 Single hybrid motifFamilyHomologous superfamily
IPR011054 Rudiment single hybrid motifFamilyHomologous superfamily
IPR011761 ATP-grasp foldDomainDomain
IPR011762 Acetyl-coenzyme A carboxyltransferase, N-terminalDomainDomain
IPR011763 Acetyl-coenzyme A carboxyltransferase, C-terminalDomainDomain
IPR011764 Biotin carboxylation domainDomainDomain
IPR013537 Acetyl-CoA carboxylase, central domainDomainDomain
IPR013815 ATP-grasp fold, subdomain 1FamilyHomologous superfamily
IPR016185 Pre-ATP-grasp domain superfamilyFamilyHomologous superfamily
IPR029045 ClpP/crotonase-like domain superfamilyFamilyHomologous superfamily
IPR034733 Acetyl-CoA carboxylaseDomainDomain

Diseases

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Drugs

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DrugNameSourceType
DB00121 BiotinDrugbanksmall molecule
DB00173 AdenineDrugbanksmall molecule
DB02859 Soraphen ADrugbanksmall molecule
DB03781 2-[4-(2,4-Dichlorophenoxy)Phenoxy]Propanoic AcidDrugbanksmall molecule
DB07870 Haloxyfop-PDrugbanksmall molecule

Interactions

3 interactions