Entity Details

Primary name TITIN_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionQ8WZ42
EntryNameTITIN_HUMAN
FullNameTitin
TaxID9606
Evidenceevidence at protein level
Length34350
SequenceStatuscomplete
DateCreated2006-06-13
DateModified2021-06-02

Ontological Relatives

GenesTTN

GO terms

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GOName
GO:0000794 condensed nuclear chromosome
GO:0002020 protease binding
GO:0002576 platelet degranulation
GO:0003300 cardiac muscle hypertrophy
GO:0004674 protein serine/threonine kinase activity
GO:0004713 protein tyrosine kinase activity
GO:0005509 calcium ion binding
GO:0005516 calmodulin binding
GO:0005524 ATP binding
GO:0005576 extracellular region
GO:0005829 cytosol
GO:0005865 striated muscle thin filament
GO:0006936 muscle contraction
GO:0006941 striated muscle contraction
GO:0007076 mitotic chromosome condensation
GO:0008307 structural constituent of muscle
GO:0010628 positive regulation of gene expression
GO:0010737 protein kinase A signaling
GO:0019899 enzyme binding
GO:0019901 protein kinase binding
GO:0030018 Z disc
GO:0030049 muscle filament sliding
GO:0030240 skeletal muscle thin filament assembly
GO:0030241 skeletal muscle myosin thick filament assembly
GO:0031430 M band
GO:0031433 telethonin binding
GO:0031674 I band
GO:0035995 detection of muscle stretch
GO:0042802 identical protein binding
GO:0042805 actinin binding
GO:0043621 protein self-association
GO:0045214 sarcomere organization
GO:0045859 regulation of protein kinase activity
GO:0048769 sarcomerogenesis
GO:0050714 positive regulation of protein secretion
GO:0050790 regulation of catalytic activity
GO:0051015 actin filament binding
GO:0051371 muscle alpha-actinin binding
GO:0051592 response to calcium ion
GO:0055003 cardiac myofibril assembly
GO:0055008 cardiac muscle tissue morphogenesis
GO:0060048 cardiac muscle contraction
GO:0070062 extracellular exosome
GO:0097493 structural molecule activity conferring elasticity
GO:0106310 protein serine kinase activity
GO:0106311 protein threonine kinase activity

Subcellular Location

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Subcellular Location
Cytoplasm
Nucleus

Domains

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DomainNameCategoryType
IPR000719 Protein kinase domainDomainDomain
IPR003598 Immunoglobulin subtype 2DomainDomain
IPR003599 Immunoglobulin subtypeDomainDomain
IPR003961 Fibronectin type IIIDomainDomain
IPR004168 PPAK motifRepeatRepeat
IPR007110 Immunoglobulin-like domainDomainDomain
IPR008266 Tyrosine-protein kinase, active siteSiteActive site
IPR011009 Protein kinase-like domain superfamilyFamilyHomologous superfamily
IPR013098 Immunoglobulin I-setDomainDomain
IPR013106 Immunoglobulin V-set domainDomainDomain
IPR013783 Immunoglobulin-like foldFamilyHomologous superfamily
IPR015129 Titin, Z repeatRepeatRepeat
IPR036116 Fibronectin type III superfamilyFamilyHomologous superfamily
IPR036179 Immunoglobulin-like domain superfamilyFamilyHomologous superfamily
IPR040849 MyBP-C, tri-helix bundle domainDomainDomain

Diseases

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Interactions

93 interactions

InteractorPartnerSourcesPublicationsLink
TITIN_HUMANTITIN_HUMANBioGRID, DIP, IntAct16407954 16962974 23414517 9804419 details
TITIN_HUMANACTN2_HUMANbhf-ucl, BioGRID, HPRD, IntAct, mbinfo, MINT11101506 11846417 16902413 23414517 9501083 details
TITIN_HUMANOBSCN_HUMANBioGRID, DIP, HPRD, IntAct, MINT, UniProt11448995 11717165 17716621 20133654 20489725 23414517 details
TITIN_HUMANNEBU_HUMANHPRD, MINT11851340 12482578 16902413 details
TITIN_HUMANFLNA_HUMANHPRD, MINT16902413 details
TITIN_HUMANTELT_HUMANbhf-ucl, BioGRID, DIP, HPRD, IntAct11846417 12446666 15582318 15802564 16407954 16962094 19622741 23414517 9645487 9804419 9817758 details
TITIN_HUMANTRI63_HUMANBioGRID, HPRD, IntAct, MINT11243782 11927605 12414993 15967462 17215480 18157088 23414517 24850911 31628103 details
TITIN_HUMANSMUF2_HUMANMINT18157088 details
TITIN_HUMANVAV2_HUMANBioGRID, IntAct18654987 23414517 details
TITIN_HUMANOBSL1_HUMANDIP, MINT20133654 20489725 details
TITIN_HUMANCAN3_HUMANBioGRID, HPRD, IntAct, MINT10987085 20860623 23414517 8537379 9185618 9642272 9763216 details
TITIN_HUMANFSTL1_HUMANMINT20860622 details
TITIN_HUMANDYSF_HUMANBioGRID, IntAct23414517 details
TITIN_HUMANOPTN_HUMANBioGRID, IntAct23414517 details
TITIN_HUMANMYOM2_HUMANBioGRID, HPRD, IntAct23414517 7505783 details
TITIN_HUMANAMOT_HUMANBioGRID, IntAct23414517 details
TITIN_HUMANANKR1_HUMANBioGRID, HPRD, IntAct14583192 23414517 details
TITIN_HUMANANR28_HUMANBioGRID, IntAct23414517 details
TITIN_HUMANASH2L_HUMANBioGRID, IntAct23414517 details
TITIN_HUMANC1T9A_HUMANBioGRID, IntAct23414517 details
TITIN_HUMANTCPZ_HUMANBioGRID, IntAct23414517 details
TITIN_HUMANCLIP4_HUMANBioGRID, IntAct23414517 details
TITIN_HUMANDNJB5_HUMANBioGRID, IntAct23414517 details
TITIN_HUMANDNJB6_HUMANBioGRID, IntAct23414517 details
TITIN_HUMANENOA_HUMANBioGRID, IntAct23414517 details
TITIN_HUMANENOB_HUMANBioGRID, IntAct23414517 details
TITIN_HUMANFHL1_HUMANBioGRID, IntAct22778266 23414517 details
TITIN_HUMANITBP2_HUMANBioGRID, IntAct23414517 details
TITIN_HUMANITB5_HUMANBioGRID, IntAct23414517 details
TITIN_HUMANJPH1_HUMANBioGRID, IntAct23414517 details
TITIN_HUMANLIMS1_HUMANBioGRID, IntAct23414517 details
TITIN_HUMANMAST2_HUMANBioGRID, IntAct23414517 details
TITIN_HUMANMYPC2_HUMANBioGRID, IntAct23414517 details
TITIN_HUMANMYBPH_HUMANBioGRID, IntAct23414517 details
TITIN_HUMANPOMP_HUMANBioGRID, IntAct23414517 details
TITIN_HUMANPYGM_HUMANBioGRID, IntAct23414517 details
TITIN_HUMANRN167_HUMANBioGRID, IntAct23414517 details
TITIN_HUMANSGCG_HUMANBioGRID, IntAct23414517 details
TITIN_HUMANSHLB1_HUMANBioGRID, IntAct23414517 details
TITIN_HUMANABLM1_HUMANBioGRID, IntAct23414517 details
TITIN_HUMANABLM2_HUMANBioGRID, IntAct23414517 details
TITIN_HUMANACTN3_HUMANBioGRID, IntAct23414517 details
TITIN_HUMANACTN4_HUMANBioGRID, IntAct23414517 details
TITIN_HUMANATPD_HUMANBioGRID, IntAct23414517 details
TITIN_HUMANCHD4_HUMANBioGRID, IntAct23414517 details
TITIN_HUMANEXOSX_HUMANBioGRID, IntAct23414517 details
TITIN_HUMANFINC_HUMANBioGRID, IntAct23414517 details
TITIN_HUMANFND3B_HUMANBioGRID, IntAct23414517 details
TITIN_HUMANGBRAP_HUMANBioGRID, IntAct23414517 details
TITIN_HUMANHS71A_HUMANBioGRID, IntAct23414517 details
TITIN_HUMANHS71B_HUMANBioGRID, IntAct23414517 details
TITIN_HUMANMYPC1_HUMANBioGRID, HPRD, IntAct1429890 23414517 details
TITIN_HUMANMYCB2_HUMANBioGRID, IntAct23414517 details
TITIN_HUMANMYOM1_HUMANBioGRID, HPRD, IntAct23414517 7588733 details
TITIN_HUMANNEK9_HUMANBioGRID, IntAct23414517 details
TITIN_HUMANNEO1_HUMANBioGRID, IntAct23414517 details
TITIN_HUMANPARD3_HUMANBioGRID, IntAct23414517 details
TITIN_HUMANSERA_HUMANBioGRID, IntAct23414517 details
TITIN_HUMANRL12_HUMANBioGRID, IntAct23414517 details
TITIN_HUMANRYR1_HUMANBioGRID, IntAct23414517 details
TITIN_HUMANSF01_HUMANBioGRID, IntAct23414517 details
TITIN_HUMANTAB2_HUMANBioGRID, IntAct23414517 details
TITIN_HUMANTTC3_HUMANBioGRID, IntAct23414517 details
TITIN_HUMANUBC9_HUMANBioGRID, IntAct23414517 details
TITIN_HUMANUGPA_HUMANBioGRID, IntAct23414517 details
TITIN_HUMANSRPK2_HUMANBioGRID, IntAct23602568 details
TITIN_HUMANACTN1_HUMANBioGRID, HPRD, mbinfo11101506 11305911 11846417 9501083 details
TITIN_HUMANCALM2_HUMANbhf-ucl, BioGRID, HPRD11178895 7607248 details
TITIN_HUMANSYNEM_HUMANMINT25447537 details
TITIN_HUMANHSPB2_HUMANbhf-ucl, BioGRID26465331 details
TITIN_HUMANANR23_HUMANBioGRID, HPRD14583192 details
TITIN_HUMANMYPN_HUMANBioGRID14583192 details
TITIN_HUMANANKR2_HUMANBioGRID, HPRD14583192 details
TITIN_HUMANMYPC3_HUMANBioGRID, HPRD12202917 8631348 details
TITIN_HUMANANK1_HUMANBioGRID, HPRD12444090 16962094 details
TITIN_HUMANFHL2_HUMANBioGRID, HPRD12432079 details
TITIN_HUMANNBR1_HUMANBioGRID15802564 details
TITIN_HUMANSQSTM_HUMANBioGRID15802564 details
TITIN_HUMANTRI55_HUMANBioGRID18157088 31628103 details
TITIN_HUMANMK01_HUMANBioGRID22778266 details
TITIN_HUMANT22D2_HUMANBioGRID27337956 details
TITIN_HUMANDFFA_HUMANIntAct17353931 details
TITIN_HUMANDDX56_HUMANIntAct17353931 details
TITIN_HUMANMCRS1_HUMANIntAct17353931 details
TITIN_HUMAN1433T_HUMANBioGRID20618440 details
TITIN_HUMANCRYAB_HUMANBioGRID, HPRD14676215 details
TITIN_HUMANCALM1_HUMANBioGRID, HPRD11178895 7607248 details
TITIN_HUMANCALM3_HUMANBioGRID, HPRD11178895 7607248 details
TITIN_HUMANGAN_HUMANBioGRID26460568 details
TITIN_HUMANHEY1_HUMANBioGRID27129302 details
TITIN_HUMANTULP3_HUMANBioGRID33187986 details
TITIN_HUMANACTS_HUMANHPRD11701614 15507486 9251807 details
TITIN_HUMANMYH9_HUMANHPRD8063857 details