Entity Details

Primary name XPF_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionQ92889
EntryNameXPF_HUMAN
FullNameDNA repair endonuclease XPF
TaxID9606
Evidenceevidence at protein level
Length916
SequenceStatuscomplete
DateCreated1997-11-01
DateModified2021-06-02

Ontological Relatives

GenesERCC4

GO terms

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GOName
GO:0000014 single-stranded DNA endodeoxyribonuclease activity
GO:0000109 nucleotide-excision repair complex
GO:0000110 nucleotide-excision repair factor 1 complex
GO:0000712 resolution of meiotic recombination intermediates
GO:0000723 telomere maintenance
GO:0000724 double-strand break repair via homologous recombination
GO:0000781 chromosome, telomeric region
GO:0001094 TFIID-class transcription factor complex binding
GO:0003684 damaged DNA binding
GO:0003697 single-stranded DNA binding
GO:0004520 endodeoxyribonuclease activity
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0006281 DNA repair
GO:0006283 transcription-coupled nucleotide-excision repair
GO:0006289 nucleotide-excision repair
GO:0006293 nucleotide-excision repair, preincision complex stabilization
GO:0006295 nucleotide-excision repair, DNA incision, 3'-to lesion
GO:0006296 nucleotide-excision repair, DNA incision, 5'-to lesion
GO:0006303 double-strand break repair via nonhomologous end joining
GO:0008022 protein C-terminus binding
GO:0009411 response to UV
GO:0009650 UV protection
GO:0010506 regulation of autophagy
GO:0032205 negative regulation of telomere maintenance
GO:0033683 nucleotide-excision repair, DNA incision
GO:0034644 cellular response to UV
GO:0036297 interstrand cross-link repair
GO:0042802 identical protein binding
GO:0047485 protein N-terminus binding
GO:0051974 negative regulation of telomerase activity
GO:0061819 telomeric DNA-containing double minutes formation
GO:0070522 ERCC4-ERCC1 complex
GO:0070911 global genome nucleotide-excision repair
GO:1901255 nucleotide-excision repair involved in interstrand cross-link repair
GO:1904357 negative regulation of telomere maintenance via telomere lengthening
GO:1905765 negative regulation of protection from non-homologous end joining at telomere
GO:1905768 negative regulation of double-stranded telomeric DNA binding
GO:1990841 promoter-specific chromatin binding

Subcellular Location

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Subcellular Location
Nucleus

Domains

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DomainNameCategoryType
IPR006166 ERCC4 domainDomainDomain
IPR006167 DNA repair protein XPFFamilyFamily
IPR010994 RuvA domain 2-likeFamilyHomologous superfamily
IPR011335 Restriction endonuclease type II-likeFamilyHomologous superfamily

Diseases

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Interactions

31 interactions

InteractorPartnerSourcesPublicationsLink
XPF_HUMANSLX4_HUMANBioGRID, HPRD, IntAct19595721 19595722 19596235 19596236 21240275 22902628 23033263 23093618 23623386 23994477 24012755 25538220 26453996 31495888 32398829 details
XPF_HUMANSLX1_HUMANBioGRID, IntAct19595721 19596235 19596236 details
XPF_HUMANERCC1_HUMANBioGRID, DIP, HPRD, IntAct10413517 11160918 14706347 14734547 15932882 16076955 16338413 17289582 17912758 19940136 21466675 21875596 22353549 22939629 23580445 24036546 24780295 25538220 25956741 26085086 26186194 26344197 26453996 28514442 31495888 8197175 9013642 9722633 details
XPF_HUMANTACC1_HUMANBioGRID, IntAct32296183 details
XPF_HUMANXPA_HUMANBioGRID, IntAct26186194 28514442 9013642 details
XPF_HUMANXPF_HUMANBioGRID, DIP15932882 17912758 22483113 details
XPF_HUMANFANCG_HUMANBioGRID20518486 details
XPF_HUMANSUMO2_HUMANBioGRID19394292 25533185 details
XPF_HUMANKIF11_HUMANBioGRID22353549 details
XPF_HUMANRAD52_HUMANBioGRID, HPRD14734547 details
XPF_HUMANRFA1_HUMANBioGRID21875596 9013642 details
XPF_HUMANRFA2_HUMANBioGRID21875596 details
XPF_HUMANSLX4I_HUMANBioGRID, IntAct19596235 31495888 details
XPF_HUMANPLK1_HUMANBioGRID, IntAct19596235 25659891 28514442 details
XPF_HUMANXPC_HUMANMINT19279666 details
XPF_HUMANEME1_HUMANIntAct17289582 details
XPF_HUMANCJ055_HUMANIntAct28514442 details
XPF_HUMANSPTN1_HUMANBioGRID, HPRD11401546 12571280 details
XPF_HUMANFANCA_HUMANBioGRID12571280 details
XPF_HUMANSPTA1_HUMANBioGRID12571280 16889989 details
XPF_HUMANERPG3_HUMANBioGRID20541997 details
XPF_HUMANERCC6_HUMANBioGRID20541997 details
XPF_HUMANTF2H1_HUMANBioGRID, HPRD11259578 details
XPF_HUMANRPB1_HUMANBioGRID16916636 details
XPF_HUMANMSH2_HUMANBioGRID14706347 details
XPF_HUMANUHRF1_HUMANBioGRID25818288 details
XPF_HUMANUBP45_HUMANBioGRID25538220 details
XPF_HUMANFACD2_HUMANBioGRID24794430 31180492 details
XPF_HUMANSHLD2_HUMANBioGRID30154076 details
XPF_HUMANDCAF7_HUMANBioGRID31493872 details
XPF_HUMANRTEL1_HUMANBioGRID32398829 details