Entity Details

Primary name MUL1_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionQ969V5
EntryNameMUL1_HUMAN
FullNameMitochondrial ubiquitin ligase activator of NFKB 1
TaxID9606
Evidenceevidence at protein level
Length352
SequenceStatuscomplete
DateCreated2007-02-20
DateModified2021-06-02

Ontological Relatives

GenesMUL1

GO terms

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GOName
GO:0000209 protein polyubiquitination
GO:0000266 mitochondrial fission
GO:0002039 p53 binding
GO:0004842 ubiquitin-protein transferase activity
GO:0005739 mitochondrion
GO:0005777 peroxisome
GO:0006915 apoptotic process
GO:0006919 activation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0007257 obsolete activation of JUN kinase activity
GO:0010637 negative regulation of mitochondrial fusion
GO:0010821 regulation of mitochondrion organization
GO:0016020 membrane
GO:0016567 protein ubiquitination
GO:0019789 SUMO transferase activity
GO:0030308 negative regulation of cell growth
GO:0030424 axon
GO:0031307 integral component of mitochondrial outer membrane
GO:0031625 ubiquitin protein ligase binding
GO:0031648 protein destabilization
GO:0033235 positive regulation of protein sumoylation
GO:0042802 identical protein binding
GO:0043025 neuronal cell body
GO:0043123 positive regulation of I-kappaB kinase/NF-kappaB signaling
GO:0045824 negative regulation of innate immune response
GO:0046872 metal ion binding
GO:0050689 negative regulation of defense response to virus by host
GO:0050821 protein stabilization
GO:0051646 mitochondrion localization
GO:0051881 regulation of mitochondrial membrane potential
GO:0051898 negative regulation of protein kinase B signaling
GO:0060339 negative regulation of type I interferon-mediated signaling pathway
GO:0061630 ubiquitin protein ligase activity
GO:0071360 cellular response to exogenous dsRNA
GO:0071650 negative regulation of chemokine (C-C motif) ligand 5 production
GO:0090141 positive regulation of mitochondrial fission
GO:1901028 regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway
GO:1903861 positive regulation of dendrite extension
GO:1904925 positive regulation of autophagy of mitochondrion in response to mitochondrial depolarization

Subcellular Location

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Subcellular Location
Mitochondrion outer membrane
Peroxisome

Domains

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DomainNameCategoryType
IPR001841 Zinc finger, RING-typeDomainDomain
IPR013083 Zinc finger, RING/FYVE/PHD-typeFamilyHomologous superfamily
IPR022170 E3 Ubiquitin ligase MUL1-likeDomainDomain

Diseases

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Interactions

45 interactions

InteractorPartnerSourcesPublicationsLink
MUL1_HUMANAPBP2_HUMANBioGRID, HPRD, IntAct16189514 19060904 32296183 details
MUL1_HUMANUB2D1_HUMANBioGRID, IntAct19690564 21597459 26018823 28763789 31929179 details
MUL1_HUMANUB2D2_HUMANBioGRID, IntAct18213395 19407830 19690564 28763789 31929179 details
MUL1_HUMANUB2D3_HUMANBioGRID, IntAct19690564 21597459 28763789 31929179 details
MUL1_HUMANUB2D4_HUMANBioGRID, IntAct19690564 28763789 details
MUL1_HUMANUB2E1_HUMANBioGRID, IntAct19690564 28763789 details
MUL1_HUMANUB2E3_HUMANBioGRID, IntAct19690564 25224329 32005965 details
MUL1_HUMANUB2L6_HUMANBioGRID, IntAct19690564 details
MUL1_HUMANUBE2U_HUMANBioGRID, IntAct19690564 details
MUL1_HUMANUBE2W_HUMANBioGRID, IntAct19690564 details
MUL1_HUMANSUMO1_HUMANBioGRID, MINT19407830 details
MUL1_HUMANUBC_HUMANBioGRID, MINT19407830 details
MUL1_HUMANTAP1_HUMANBioGRID, IntAct21988832 details
MUL1_HUMANTRIM9_HUMANBioGRID, IntAct25416956 details
MUL1_HUMANREEP2_HUMANBioGRID, IntAct32296183 details
MUL1_HUMANKR108_HUMANBioGRID, IntAct32296183 details
MUL1_HUMANDNM1L_HUMANBioGRID19407830 details
MUL1_HUMANAKT1_HUMANBioGRID22410793 details
MUL1_HUMANP53_HUMANBioGRID21597459 31235254 31929179 details
MUL1_HUMANMUL1_HUMANBioGRID18213395 31235254 details
MUL1_HUMANUB2E2_HUMANBioGRID25224329 details
MUL1_HUMANUB2G2_HUMANBioGRID25224329 details
MUL1_HUMANUB2L3_HUMANBioGRID25224329 details
MUL1_HUMANULK1_HUMANBioGRID26018823 details
MUL1_HUMANP73_HUMANBioGRID26435500 details
MUL1_HUMANHTRA2_HUMANBioGRID24709290 details
MUL1_HUMANM3K7_HUMANBioGRID27082251 details
MUL1_HUMANSTING_HUMANBioGRID28763789 details
MUL1_HUMANUBE2N_HUMANBioGRID28763789 details
MUL1_HUMANUB2R1_HUMANBioGRID28763789 details
MUL1_HUMANUB2R2_HUMANBioGRID28763789 details
MUL1_HUMANUB2V2_HUMANBioGRID28763789 details
MUL1_HUMANEHD1_HUMANBioGRID28596240 details
MUL1_HUMANUBXN7_HUMANBioGRID32005965 details
MUL1_HUMANRAGP1_HUMANBioGRID32005965 details
MUL1_HUMANUBC9_HUMANBioGRID, MINT19407830 details
MUL1_HUMANTANK_HUMANMINT24841215 details
MUL1_HUMANVPS35_HUMANBioGRID20619655 details
MUL1_HUMANVP26A_HUMANBioGRID20619655 28596240 details
MUL1_HUMANMAVS_HUMANBioGRID23399697 details
MUL1_HUMANTRAF2_HUMANBioGRID24841215 details
MUL1_HUMANGBRAP_HUMANBioGRID25224329 details
MUL1_HUMANATG13_HUMANBioGRID26018823 details
MUL1_HUMANANFY1_HUMANBioGRID28596240 details
MUL1_HUMANTERA_HUMANBioGRID29599191 details