Entity Details

Primary name KMT2D_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionO14686
EntryNameKMT2D_HUMAN
FullNameHistone-lysine N-methyltransferase 2D
TaxID9606
Evidenceevidence at protein level
Length5537
SequenceStatuscomplete
DateCreated2003-10-10
DateModified2021-06-02

Ontological Relatives

GenesKMT2D

GO terms

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GOName
GO:0000976 transcription cis-regulatory region binding
GO:0001555 oocyte growth
GO:0003677 DNA binding
GO:0003713 transcription coactivator activity
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0006342 chromatin silencing
GO:0006355 regulation of transcription, DNA-templated
GO:0008284 positive regulation of cell population proliferation
GO:0033148 positive regulation of intracellular estrogen receptor signaling pathway
GO:0035097 histone methyltransferase complex
GO:0042393 histone binding
GO:0042800 histone methyltransferase activity (H3-K4 specific)
GO:0043627 response to estrogen
GO:0044648 histone H3-K4 dimethylation
GO:0044666 MLL3/4 complex
GO:0045652 regulation of megakaryocyte differentiation
GO:0045944 positive regulation of transcription by RNA polymerase II
GO:0046872 metal ion binding
GO:0048477 oogenesis
GO:0051568 histone H3-K4 methylation
GO:0080182 histone H3-K4 trimethylation
GO:0097692 histone H3-K4 monomethylation
GO:1904837 beta-catenin-TCF complex assembly

Subcellular Location

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Subcellular Location
Nucleus

Domains

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DomainNameCategoryType
IPR001214 SET domainDomainDomain
IPR001841 Zinc finger, RING-typeDomainDomain
IPR001965 Zinc finger, PHD-typeDomainDomain
IPR003616 Post-SET domainDomainDomain
IPR003888 FY-rich, N-terminalDomainDomain
IPR003889 FY-rich, C-terminalDomainDomain
IPR009071 High mobility group box domainDomainDomain
IPR011011 Zinc finger, FYVE/PHD-typeFamilyHomologous superfamily
IPR013083 Zinc finger, RING/FYVE/PHD-typeFamilyHomologous superfamily
IPR019787 Zinc finger, PHD-fingerDomainDomain
IPR034732 Extended PHD (ePHD) domainDomainDomain
IPR036910 High mobility group box domain superfamilyFamilyHomologous superfamily
IPR037890 Histone-lysine N-methyltransferase 2DFamilyFamily
IPR041961 KMT2D, ePHD1 domainDomainDomain
IPR041964 KMT2D, ePHD2 domainDomainDomain

Diseases

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Interactions

31 interactions

InteractorPartnerSourcesPublicationsLink
KMT2D_HUMANSMAD1_HUMANBioGRID, HPRD, MINT15231748 details
KMT2D_HUMANSMAD9_HUMANBioGRID, HPRD, MINT15231748 details
KMT2D_HUMANESR1_HUMANBioGRID, HPRD, IntAct16603732 21502505 28336670 details
KMT2D_HUMANRBBP5_HUMANBioGRID, IntAct, UniProt15960974 16603732 17178841 17500065 17925232 24081332 24491801 24981860 27563068 29785026 30107592 30604749 31076518 details
KMT2D_HUMANASH2L_HUMANBioGRID, DIP, HPRD, IntAct, MINT, UniProt12482968 16603732 17178841 17925232 24491801 24981860 26886794 27563068 30107592 30604749 31076518 32350066 34079125 details
KMT2D_HUMANWDR5_HUMANBioGRID, IntAct, MINT, UniProt15960974 15960975 16603732 17178841 17500065 17925232 22266653 22665483 22689669 24491801 24788516 24981860 26186194 27563068 27705803 28514442 30107592 30604749 32350066 details
KMT2D_HUMANTOPB1_HUMANUniProt17913746 details
KMT2D_HUMANCTNB1_HUMANBioGRID16510874 16510875 details
KMT2D_HUMANRPB1_HUMANBioGRID16199523 details
KMT2D_HUMANPYGO2_HUMANBioGRID20937768 details
KMT2D_HUMANH32_HUMANBioGRID22266653 details
KMT2D_HUMANAKT1_HUMANBioGRID28336670 details
KMT2D_HUMANH4_HUMANBioGRID30604749 30804502 31127101 details
KMT2D_HUMANFBXW7_HUMANBioGRID32350066 details
KMT2D_HUMANKDM6A_HUMANBioGRID, MINT, UniProt17178841 17761849 24491801 24981860 29785026 32350066 details
KMT2D_HUMANNCOA6_HUMANBioGRID, UniProt12482968 17178841 24981860 32350066 details
KMT2D_HUMANANDR_HUMANBioGRID, DIP22722839 28611094 32814769 details
KMT2D_HUMANCXXC1_HUMANBioGRID18082152 24981860 details
KMT2D_HUMANE2F5_HUMANBioGRID16951254 details
KMT2D_HUMANE2F6_HUMANBioGRID16951254 details
KMT2D_HUMANE2F3_HUMANBioGRID16951254 details
KMT2D_HUMANE2F2_HUMANBioGRID16951254 details
KMT2D_HUMANSRRM1_HUMANBioGRID16159877 details
KMT2D_HUMANMEF2D_HUMANBioGRID18026121 details
KMT2D_HUMANWDR82_HUMANBioGRID20516061 details
KMT2D_HUMANKDM4B_HUMANBioGRID21502505 details
KMT2D_HUMANMEN1_HUMANBioGRID, HPRD14992727 24981860 details
KMT2D_HUMANSENP3_HUMANBioGRID24930734 details
KMT2D_HUMANGCR_HUMANBioGRID28611094 31182584 32139118 details
KMT2D_HUMANSPT5H_HUMANBioGRID29395067 details
KMT2D_HUMANSMG7_HUMANBioGRID29395067 details