Entity Details

Primary name APH1A_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionQ96BI3
EntryNameAPH1A_HUMAN
FullNameGamma-secretase subunit APH-1A
TaxID9606
Evidenceevidence at protein level
Length265
SequenceStatuscomplete
DateCreated2003-09-26
DateModified2021-06-02

Ontological Relatives

GenesAPH1A

GO terms

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GOName
GO:0001656 metanephros development
GO:0005739 mitochondrion
GO:0005769 early endosome
GO:0005783 endoplasmic reticulum
GO:0005789 endoplasmic reticulum membrane
GO:0005794 Golgi apparatus
GO:0005886 plasma membrane
GO:0005887 integral component of plasma membrane
GO:0006509 membrane protein ectodomain proteolysis
GO:0007219 Notch signaling pathway
GO:0007220 Notch receptor processing
GO:0008021 synaptic vesicle
GO:0010008 endosome membrane
GO:0010950 positive regulation of endopeptidase activity
GO:0016020 membrane
GO:0016021 integral component of membrane
GO:0016485 protein processing
GO:0019899 enzyme binding
GO:0030674 protein-macromolecule adaptor activity
GO:0031293 membrane protein intracellular domain proteolysis
GO:0032580 Golgi cisterna membrane
GO:0034205 amyloid-beta formation
GO:0035333 Notch receptor processing, ligand-dependent
GO:0042982 amyloid precursor protein metabolic process
GO:0042987 amyloid precursor protein catabolic process
GO:0043065 positive regulation of apoptotic process
GO:0043085 positive regulation of catalytic activity
GO:0048013 ephrin receptor signaling pathway
GO:0061133 endopeptidase activator activity
GO:0070765 gamma-secretase complex
GO:0099056 integral component of presynaptic membrane
GO:1990000 amyloid fibril formation

Subcellular Location

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Subcellular Location
Endoplasmic reticulum membrane
Golgi apparatus

Domains

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DomainNameCategoryType
IPR009294 Gamma-secretase subunit Aph-1FamilyFamily

Diseases

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Drugs

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DrugNameSourceType
DB05171 E-2012Drugbanksmall molecule

Interactions

42 interactions

InteractorPartnerSourcesPublicationsLink
APH1A_HUMANCREB3_HUMANBioGRID, MINT21516116 details
APH1A_HUMANATF4_HUMANBioGRID, IntAct21988832 details
APH1A_HUMANZEP1_HUMANBioGRID, IntAct21988832 details
APH1A_HUMANHES1_HUMANBioGRID, IntAct21988832 details
APH1A_HUMANTPO_HUMANBioGRID, IntAct21988832 details
APH1A_HUMANTLE1_HUMANBioGRID, IntAct21988832 details
APH1A_HUMANKLF11_HUMANBioGRID, IntAct21988832 details
APH1A_HUMANBHE40_HUMANBioGRID, IntAct21988832 details
APH1A_HUMANGPTC8_HUMANBioGRID, IntAct21988832 details
APH1A_HUMANRFOX2_HUMANBioGRID, IntAct21988832 details
APH1A_HUMANEM55_HUMANBioGRID, IntAct32296183 details
APH1A_HUMANTM140_HUMANBioGRID, IntAct32296183 details
APH1A_HUMANTM218_HUMANBioGRID, IntAct32296183 details
APH1A_HUMANASGR1_HUMANBioGRID, IntAct32296183 details
APH1A_HUMANS39A9_HUMANBioGRID, IntAct32296183 details
APH1A_HUMANIBP5_HUMANBioGRID, IntAct32296183 details
APH1A_HUMANMRAP2_HUMANBioGRID, IntAct32296183 details
APH1A_HUMANSMAGP_HUMANBioGRID, IntAct32296183 details
APH1A_HUMANFIS1_HUMANBioGRID, IntAct32296183 details
APH1A_HUMANSCND1_HUMANBioGRID, IntAct32296183 details
APH1A_HUMANMFSD6_HUMANBioGRID, IntAct32296183 details
APH1A_HUMANANR46_HUMANBioGRID, IntAct32296183 details
APH1A_HUMANAPOD_HUMANBioGRID, IntAct32296183 details
APH1A_HUMANLAT_HUMANBioGRID, IntAct32296183 details
APH1A_HUMANS38A7_HUMANBioGRID, IntAct32296183 details
APH1A_HUMANSERP1_HUMANBioGRID, IntAct32296183 details
APH1A_HUMANFXYD6_HUMANBioGRID, IntAct32296183 details
APH1A_HUMANDRD2_HUMANBioGRID, MINT28298427 details
APH1A_HUMANGPR35_HUMANBioGRID, MINT28298427 details
APH1A_HUMANARP3_HUMANIntAct32814053 details
APH1A_HUMANCYH1_HUMANIntAct32814053 details
APH1A_HUMANFYN_HUMANIntAct32814053 details
APH1A_HUMANA4_HUMANIntAct32814053 details
APH1A_HUMANGLP1R_HUMANBioGRID23864651 details
APH1A_HUMANTARG1_HUMANBioGRID32296183 details
APH1A_HUMANNICA_HUMANBioGRID, DIP, HPRD, IntAct, MINT12297508 12471034 12857757 14572442 15257293 15474363 17911105 18201567 18667537 19376115 26280335 details
APH1A_HUMANPEN2_HUMANBioGRID, DIP, HPRD, MINT12740439 14572442 15322109 15474363 17911105 18667537 19376115 22074918 26280335 details
APH1A_HUMANPSN1_HUMANBioGRID, DIP, HPRD, UniProt12297508 12471034 14572442 15474363 17911105 18667537 26280335 30559186 details
APH1A_HUMANPSN2_HUMANBioGRID, HPRD12297508 12471034 15474363 details
APH1A_HUMANAPH1A_HUMANBioGRID15474363 details
APH1A_HUMANERLN2_HUMANBioGRID22771797 details
APH1A_HUMANTMEDA_HUMANHPRD16641999 details