Entity Details

Primary name NRP1_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionO14786
EntryNameNRP1_HUMAN
FullNameNeuropilin-1
TaxID9606
Evidenceevidence at protein level
Length923
SequenceStatuscomplete
DateCreated2000-05-30
DateModified2021-06-02

Ontological Relatives

GenesNRP1

GO terms

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GOName
GO:0001525 angiogenesis
GO:0001569 branching involved in blood vessel morphogenesis
GO:0001764 neuron migration
GO:0001938 positive regulation of endothelial cell proliferation
GO:0002040 sprouting angiogenesis
GO:0002042 cell migration involved in sprouting angiogenesis
GO:0002116 semaphorin receptor complex
GO:0003148 outflow tract septum morphogenesis
GO:0005021 vascular endothelial growth factor-activated receptor activity
GO:0005096 GTPase activator activity
GO:0005615 extracellular space
GO:0005769 early endosome
GO:0005829 cytosol
GO:0005886 plasma membrane
GO:0005925 focal adhesion
GO:0006930 substrate-dependent cell migration, cell extension
GO:0007165 signal transduction
GO:0007229 integrin-mediated signaling pathway
GO:0007267 cell-cell signaling
GO:0007411 axon guidance
GO:0008201 heparin binding
GO:0009611 response to wounding
GO:0009887 animal organ morphogenesis
GO:0009986 cell surface
GO:0010595 positive regulation of endothelial cell migration
GO:0014911 positive regulation of smooth muscle cell migration
GO:0015026 coreceptor activity
GO:0016021 integral component of membrane
GO:0017154 semaphorin receptor activity
GO:0019838 growth factor binding
GO:0019955 cytokine binding
GO:0021675 nerve development
GO:0030424 axon
GO:0030426 growth cone
GO:0031290 retinal ganglion cell axon guidance
GO:0031410 cytoplasmic vesicle
GO:0031532 actin cytoskeleton reorganization
GO:0031966 mitochondrial membrane
GO:0032489 regulation of Cdc42 protein signal transduction
GO:0034446 substrate adhesion-dependent cell spreading
GO:0035729 cellular response to hepatocyte growth factor stimulus
GO:0035767 endothelial cell chemotaxis
GO:0035924 cellular response to vascular endothelial growth factor stimulus
GO:0038085 vascular endothelial growth factor binding
GO:0038189 neuropilin signaling pathway
GO:0038190 VEGF-activated neuropilin signaling pathway
GO:0042327 positive regulation of phosphorylation
GO:0043005 neuron projection
GO:0043025 neuronal cell body
GO:0043235 receptor complex
GO:0043542 endothelial cell migration
GO:0046718 viral entry into host cell
GO:0046872 metal ion binding
GO:0048008 platelet-derived growth factor receptor signaling pathway
GO:0048010 vascular endothelial growth factor receptor signaling pathway
GO:0048012 hepatocyte growth factor receptor signaling pathway
GO:0048842 positive regulation of axon extension involved in axon guidance
GO:0048843 negative regulation of axon extension involved in axon guidance
GO:0048844 artery morphogenesis
GO:0048846 axon extension involved in axon guidance
GO:0050731 positive regulation of peptidyl-tyrosine phosphorylation
GO:0050918 positive chemotaxis
GO:0051491 positive regulation of filopodium assembly
GO:0051496 positive regulation of stress fiber assembly
GO:0051894 positive regulation of focal adhesion assembly
GO:0060301 positive regulation of cytokine activity
GO:0060385 axonogenesis involved in innervation
GO:0060627 regulation of vesicle-mediated transport
GO:0060978 angiogenesis involved in coronary vascular morphogenesis
GO:0061299 retina vasculature morphogenesis in camera-type eye
GO:0061549 sympathetic ganglion development
GO:0070374 positive regulation of ERK1 and ERK2 cascade
GO:0071526 semaphorin-plexin signaling pathway
GO:0071679 commissural neuron axon guidance
GO:0090259 regulation of retinal ganglion cell axon guidance
GO:0097102 endothelial tip cell fate specification
GO:0097443 sorting endosome
GO:0097475 motor neuron migration
GO:0097490 sympathetic neuron projection extension
GO:0097491 sympathetic neuron projection guidance
GO:0150018 basal dendrite development
GO:0150020 basal dendrite arborization
GO:1900026 positive regulation of substrate adhesion-dependent cell spreading
GO:1901166 neural crest cell migration involved in autonomic nervous system development
GO:1902285 semaphorin-plexin signaling pathway involved in neuron projection guidance
GO:1902336 positive regulation of retinal ganglion cell axon guidance
GO:1902946 protein localization to early endosome
GO:2000251 positive regulation of actin cytoskeleton reorganization

Subcellular Location

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Subcellular Location
Cell membrane
Cytoplasm
Mitochondrion membrane
Secreted

Domains

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DomainNameCategoryType
IPR000421 Coagulation factor 5/8 C-terminal domainDomainDomain
IPR000859 CUB domainDomainDomain
IPR000998 MAM domainDomainDomain
IPR008979 Galactose-binding-like domain superfamilyFamilyHomologous superfamily
IPR013320 Concanavalin A-like lectin/glucanase domain superfamilyFamilyHomologous superfamily
IPR014648 NeuropilinFamilyFamily
IPR022579 Neuropilin, C-terminalDomainDomain
IPR027146 Neuropilin-1FamilyFamily
IPR035914 Spermadhesin, CUB domain superfamilyFamilyHomologous superfamily

Diseases

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Interactions

32 interactions

InteractorPartnerSourcesPublicationsLink
NRP1_HUMANVEGFA_HUMANBioGRID, HPRD, IntAct, MINT10409677 11886873 11986311 16423422 16763549 17222790 18325345 20363638 21939755 22318724 22897854 26804163 30236477 9529250 details
NRP1_HUMANRL27_HUMANBioGRID, IntAct21988832 details
NRP1_HUMANFLNA_HUMANMINT24021649 details
NRP1_HUMANPLGF_HUMANBioGRID, HPRD11986311 details
NRP1_HUMANVEGFB_HUMANBioGRID, HPRD10409677 details
NRP1_HUMANTGFR2_HUMANBioGRID20675371 21186301 details
NRP1_HUMANTGFR1_HUMANBioGRID20675371 21186301 details
NRP1_HUMANL1CAM_HUMANBioGRID16377081 25315821 details
NRP1_HUMANTGBR3_HUMANBioGRID21186301 details
NRP1_HUMANPLXA1_HUMANBioGRID, HPRD10520994 11239433 11886873 25315821 details
NRP1_HUMANNRP1_HUMANBioGRID, HPRD25315821 9856463 details
NRP1_HUMANNRP2_HUMANBioGRID, HPRD25315821 9856463 details
NRP1_HUMANPLXB1_HUMANBioGRID25315821 details
NRP1_HUMANSEM3A_HUMANBioGRID, HPRD10520994 11886873 9331348 details
NRP1_HUMANFGF2_HUMANBioGRID, HPRD15695515 30236477 details
NRP1_HUMANVGFR2_HUMANBioGRID, HPRD, IntAct, MINT11333271 11886873 11948691 16763549 17222790 19857463 26037503 details
NRP1_HUMANVGFR1_HUMANHPRD, IntAct10842181 23452854 details
NRP1_HUMANITA5_HUMANDIP19175293 details
NRP1_HUMANPLXA2_HUMANDIP19243221 details
NRP1_HUMANSRRM1_HUMANBioGRID16159877 details
NRP1_HUMANPLVAP_HUMANBioGRID22627768 details
NRP1_HUMANPDGFB_HUMANBioGRID16847823 20577048 details
NRP1_HUMANITA6_HUMANBioGRID29755126 details
NRP1_HUMANGIPC1_HUMANBioGRID, HPRD10414980 15978582 27481513 29755126 details
NRP1_HUMANPLXD1_HUMANBioGRID26037503 details
NRP1_HUMANSEM3F_HUMANHPRD9883722 details
NRP1_HUMANSEM3B_HUMANHPRD10196546 details
NRP1_HUMANFGF4_HUMANHPRD15695515 details
NRP1_HUMANFGF7_HUMANHPRD15695515 details
NRP1_HUMANSEM3C_HUMANHPRD9331348 details
NRP1_HUMANFGF1_HUMANHPRD15695515 details
NRP1_HUMANFGFR1_HUMANHPRD15695515 details