Entity Details

Primary name ITCH_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionQ96J02
EntryNameITCH_HUMAN
FullNameE3 ubiquitin-protein ligase Itchy homolog
TaxID9606
Evidenceevidence at protein level
Length903
SequenceStatuscomplete
DateCreated2003-10-03
DateModified2021-06-02

Ontological Relatives

GenesITCH

GO terms

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GOName
GO:0000209 protein polyubiquitination
GO:0001558 regulation of cell growth
GO:0004842 ubiquitin-protein transferase activity
GO:0005654 nucleoplasm
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0005886 plasma membrane
GO:0006511 ubiquitin-dependent protein catabolic process
GO:0006915 apoptotic process
GO:0006954 inflammatory response
GO:0007219 Notch signaling pathway
GO:0016020 membrane
GO:0016567 protein ubiquitination
GO:0031410 cytoplasmic vesicle
GO:0031901 early endosome membrane
GO:0032088 negative regulation of NF-kappaB transcription factor activity
GO:0032480 negative regulation of type I interferon production
GO:0032991 protein-containing complex
GO:0035519 protein K29-linked ubiquitination
GO:0043021 ribonucleoprotein complex binding
GO:0043066 negative regulation of apoptotic process
GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process
GO:0043231 intracellular membrane-bounded organelle
GO:0044389 ubiquitin-like protein ligase binding
GO:0045087 innate immune response
GO:0045236 CXCR chemokine receptor binding
GO:0045732 positive regulation of protein catabolic process
GO:0046329 negative regulation of JNK cascade
GO:0046718 viral entry into host cell
GO:0050687 negative regulation of defense response to virus
GO:0051607 defense response to virus
GO:0051865 protein autoubiquitination
GO:0061630 ubiquitin protein ligase activity
GO:0070062 extracellular exosome
GO:0070423 nucleotide-binding oligomerization domain containing signaling pathway
GO:0070534 protein K63-linked ubiquitination
GO:0070936 protein K48-linked ubiquitination
GO:0090085 regulation of protein deubiquitination
GO:1902036 regulation of hematopoietic stem cell differentiation
GO:1990763 arrestin family protein binding
GO:2000646 positive regulation of receptor catabolic process

Subcellular Location

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Subcellular Location
Cell membrane
Cytoplasm
Early endosome membrane
Endosome membrane
Nucleus

Domains

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DomainNameCategoryType
IPR000008 C2 domainDomainDomain
IPR000569 HECT domainDomainDomain
IPR001202 WW domainDomainDomain
IPR024928 E3 ubiquitin-protein ligase, SMURF1 typeFamilyFamily
IPR035892 C2 domain superfamilyFamilyHomologous superfamily
IPR035983 HECT, E3 ligase catalytic domainFamilyHomologous superfamily
IPR036020 WW domain superfamilyFamilyHomologous superfamily

Diseases

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Interactions

184 interactions

InteractorPartnerSourcesPublicationsLink
ITCH_HUMANSH3G2_HUMANBioGRID, HPRD, MINT14684745 26613292 28235806 details
ITCH_HUMANCASL_HUMANBioGRID, HPRD, MINT15051726 details
ITCH_HUMANCBLC_HUMANBioGRID, HPRD, MINT12226085 details
ITCH_HUMANSGK3_HUMANBioGRID, HPRD, MINT16888620 details
ITCH_HUMANDTX1_HUMANBioGRID, HPRD, MINT17028573 18628966 details
ITCH_HUMANP73_HUMANBioGRID, DIP, HPRD, MINT15678106 17110958 17592138 30603043 32513985 details
ITCH_HUMANUBB_HUMANIntAct17719543 details
ITCH_HUMANUB2E2_HUMANBioGRID, IntAct19549727 30017913 details
ITCH_HUMANUBC_HUMANBioGRID, MINT19343052 22496338 23287719 23644597 25723849 30017913 details
ITCH_HUMANSPART_HUMANBioGRID, IntAct16055720 19307600 19580544 19765186 20504295 28514442 details
ITCH_HUMANSNX9_HUMANBioGRID, MINT20491914 details
ITCH_HUMANMAR1_HUMANBioGRID, MINT15703212 20491914 details
ITCH_HUMANRNF11_HUMANBioGRID, HPRD, I2D14559117 19131965 20676133 22507528 28292929 31985874 details
ITCH_HUMANGLI1_HUMANBioGRID, I2D20818436 31278361 details
ITCH_HUMANWASL_HUMANBioGRID, IntAct23414517 details
ITCH_HUMANCYLD_HUMANBioGRID, InnateDB22057290 details
ITCH_HUMANP4K2A_HUMANMINT23146885 details
ITCH_HUMANLRRK1_HUMANBioGRID, IntAct24947832 29513927 details
ITCH_HUMANASPP2_HUMANBioGRID, MINT25436413 28400336 details
ITCH_HUMANARRD3_HUMANBioGRID, IntAct23236378 28514442 29416926 details
ITCH_HUMANARRD1_HUMANBioGRID, IntAct21191027 23236378 23886940 26186194 28514442 details
ITCH_HUMANCPSF6_HUMANBioGRID, HPRD, IntAct16055720 26508657 28514442 details
ITCH_HUMANP63_HUMANBioGRID, DIP16908849 20855944 22935697 23370280 25485500 details
ITCH_HUMANN4BP1_HUMANBioGRID, DIP17592138 details
ITCH_HUMANERBB4_HUMANBioGRID, DIP17463226 18334649 details
ITCH_HUMANJPH3_HUMANIntAct32814053 details
ITCH_HUMANNUMB_HUMANBioGRID, HPRD12682059 18628966 20818436 details
ITCH_HUMANSCNNA_HUMANBioGRID11244092 details
ITCH_HUMANSCNNB_HUMANBioGRID11244092 details
ITCH_HUMANATN1_HUMANBioGRID, HPRD9647693 details
ITCH_HUMANCXCR4_HUMANBioGRID19116316 22275353 24489825 28264927 details
ITCH_HUMANARRB2_HUMANBioGRID17947233 18544533 details
ITCH_HUMANITCH_HUMANBioGRID, HPRD11526121 11724934 16055720 16446428 17038327 17592138 17719543 17996703 18718449 19997087 22496338 23146885 24790097 26949039 28475870 28747490 31578285 details
ITCH_HUMANNFE2_HUMANBioGRID11318614 18718448 details
ITCH_HUMANUB2L3_HUMANBioGRID15350225 15678106 17038327 17592138 17719543 17996703 18718449 20068034 22009753 25632008 25723849 26245901 26949039 27182664 29212706 29378950 29515120 29643511 30017913 details
ITCH_HUMANUSP9X_HUMANBioGRID17038327 19341794 26508657 details
ITCH_HUMANJUN_HUMANBioGRID, HPRD16901904 17110928 19806201 19818398 details
ITCH_HUMANFYN_HUMANBioGRID16387660 details
ITCH_HUMANSMAD3_HUMANBioGRID15051726 details
ITCH_HUMANRPB1_HUMANBioGRID, HPRD16055720 26508657 details
ITCH_HUMANCPSF5_HUMANBioGRID16055720 details
ITCH_HUMANUBP2L_HUMANBioGRID16055720 details
ITCH_HUMANOCLN_HUMANBioGRID, HPRD11782481 19478092 33100129 34079125 details
ITCH_HUMANMP2K4_HUMANBioGRID19737936 details
ITCH_HUMANLATS1_HUMANBioGRID21212414 21383157 23564455 24107629 28416659 34079125 details
ITCH_HUMANLAPM5_HUMANBioGRID22009753 details
ITCH_HUMANSMAD2_HUMANBioGRID15350225 details
ITCH_HUMANSTAM1_HUMANBioGRID22275353 26508657 details
ITCH_HUMANSTAM2_HUMANBioGRID22275353 details
ITCH_HUMANARHG7_HUMANBioGRID17652093 26613292 28235806 details
ITCH_HUMANKAPCA_HUMANBioGRID17437719 details
ITCH_HUMANCSK21_HUMANBioGRID17437719 details
ITCH_HUMANTXNIP_HUMANBioGRID20068034 26527736 27437069 29378950 32901881 details
ITCH_HUMANMK08_HUMANBioGRID16446428 details
ITCH_HUMANDVL2_HUMANBioGRID22826439 26701932 details
ITCH_HUMANBECN1_HUMANBioGRID21936852 details
ITCH_HUMANLITAF_HUMANBioGRID21326863 25963657 details
ITCH_HUMANGNAI2_HUMANBioGRID23071112 details
ITCH_HUMANUB2E1_HUMANBioGRID15350225 19737936 30017913 details
ITCH_HUMANUB2G1_HUMANBioGRID16446428 22826439 details
ITCH_HUMANUB2D2_HUMANBioGRID11724934 22496338 25723849 26245901 29643511 30017913 details
ITCH_HUMANUB2E3_HUMANBioGRID22496338 details
ITCH_HUMANUB2J2_HUMANBioGRID22496338 details
ITCH_HUMANUB2R1_HUMANBioGRID22496338 30017913 details
ITCH_HUMANUBE2K_HUMANBioGRID22496338 30017913 details
ITCH_HUMANPO5F1_HUMANBioGRID19997087 23255053 details
ITCH_HUMANRASF5_HUMANBioGRID23538446 32690868 details
ITCH_HUMANUB2D3_HUMANBioGRID23644597 25723849 30017913 details
ITCH_HUMANARI1A_HUMANBioGRID16055720 details
ITCH_HUMANRMP_HUMANBioGRID16055720 details
ITCH_HUMANEWS_HUMANBioGRID16055720 details
ITCH_HUMANRPB2_HUMANBioGRID16055720 details
ITCH_HUMANRPB3_HUMANBioGRID16055720 details
ITCH_HUMANRPAB1_HUMANBioGRID16055720 details
ITCH_HUMANSMRC1_HUMANBioGRID16055720 details
ITCH_HUMANSMRC2_HUMANBioGRID16055720 details
ITCH_HUMANSMCE1_HUMANBioGRID16055720 details
ITCH_HUMANDAZP1_HUMANBioGRID16055720 details
ITCH_HUMANRPAP2_HUMANBioGRID16055720 details
ITCH_HUMANHNRPL_HUMANBioGRID16055720 28611215 details
ITCH_HUMANHNRL1_HUMANBioGRID16055720 details
ITCH_HUMANCPSF7_HUMANBioGRID16055720 details
ITCH_HUMANPABP1_HUMANBioGRID16055720 details
ITCH_HUMANSF01_HUMANBioGRID16055720 details
ITCH_HUMANRPAP3_HUMANBioGRID16055720 details
ITCH_HUMANUBAP2_HUMANBioGRID16055720 details
ITCH_HUMANWBP2_HUMANBioGRID16055720 26508657 27578003 details
ITCH_HUMANDTX3L_HUMANBioGRID24790097 details
ITCH_HUMANIMB1_HUMANBioGRID23538446 details
ITCH_HUMANNFIP1_HUMANBioGRID25632008 26245901 28747490 details
ITCH_HUMANTAB1_HUMANBioGRID25714464 details
ITCH_HUMANUB2D1_HUMANBioGRID25723849 28747490 30017913 details
ITCH_HUMANGLIS3_HUMANBioGRID26147758 details
ITCH_HUMANBIN1_HUMANBioGRID26613292 28235806 details
ITCH_HUMANPACN1_HUMANBioGRID26613292 28235806 details
ITCH_HUMANITSN1_HUMANBioGRID26613292 details
ITCH_HUMANSMN_HUMANBioGRID26908624 details
ITCH_HUMANUBC12_HUMANBioGRID27245101 details
ITCH_HUMANJUNB_HUMANBioGRID27245101 28747490 details
ITCH_HUMANMALD2_HUMANBioGRID28436082 33100129 details
ITCH_HUMANSH3G1_HUMANBioGRID28235806 details
ITCH_HUMANSUFU_HUMANBioGRID29515120 details
ITCH_HUMANUBE2C_HUMANBioGRID30017913 details
ITCH_HUMANUB2D4_HUMANBioGRID30017913 details
ITCH_HUMANUBE2O_HUMANBioGRID30017913 details
ITCH_HUMANUB2Q1_HUMANBioGRID30017913 details
ITCH_HUMANUB2Q2_HUMANBioGRID30017913 details
ITCH_HUMANUB2R2_HUMANBioGRID30017913 details
ITCH_HUMANBRAF_HUMANBioGRID31015455 details
ITCH_HUMANRAF1_HUMANBioGRID31015455 details
ITCH_HUMANMP2K1_HUMANBioGRID31015455 details
ITCH_HUMANRASN_HUMANBioGRID31015455 details
ITCH_HUMANKSR1_HUMANBioGRID31015455 details
ITCH_HUMAN1433T_HUMANBioGRID31015455 details
ITCH_HUMANTMG4_HUMANBioGRID23873930 details
ITCH_HUMANCBL_HUMANBioGRID, HPRD, MINT12226085 19341794 details
ITCH_HUMAN1433S_HUMANBioGRID, MINT15778465 details
ITCH_HUMANSNX18_HUMANBioGRID, MINT20491914 details
ITCH_HUMANFXL15_HUMANBioGRID, MINT21572392 details
ITCH_HUMANP53_HUMANBioGRID, DIP16908849 18559494 21474069 32807901 details
ITCH_HUMANRIPK1_HUMANBioGRID, HPRD19131965 details
ITCH_HUMANARRB1_HUMANBioGRID17947233 18544533 details
ITCH_HUMANCFLAR_HUMANBioGRID18559494 19090833 19808964 21474069 30736843 31443721 details
ITCH_HUMANYAP1_HUMANBioGRID17110958 details
ITCH_HUMANSMAD7_HUMANBioGRID15946939 22773947 28400336 details
ITCH_HUMANHGS_HUMANBioGRID14602072 26508657 details
ITCH_HUMANBID_HUMANBioGRID20392206 details
ITCH_HUMANNFIP2_HUMANBioGRID, HPRD15252135 20522958 details
ITCH_HUMANTRPV4_HUMANBioGRID, HPRD17110928 20650893 details
ITCH_HUMANSHLB1_HUMANBioGRID19341794 details
ITCH_HUMANTR10B_HUMANBioGRID19808964 details
ITCH_HUMANTGFR1_HUMANBioGRID15350225 details
ITCH_HUMANAMOT_HUMANBioGRID22385262 23564455 24101513 details
ITCH_HUMANTAXB1_HUMANBioGRID18246070 details
ITCH_HUMANTRAF6_HUMANBioGRID18246070 details
ITCH_HUMANCAV1_HUMANBioGRID22275353 details
ITCH_HUMANMAVS_HUMANBioGRID19881509 27736772 details
ITCH_HUMANPCBP2_HUMANBioGRID19881509 details
ITCH_HUMANDVL1_HUMANBioGRID22826439 details
ITCH_HUMANDVL3_HUMANBioGRID22826439 28455968 details
ITCH_HUMANUBP12_HUMANBioGRID22778262 26811477 details
ITCH_HUMANWDR48_HUMANBioGRID22778262 details
ITCH_HUMANKLF10_HUMANBioGRID18278048 details
ITCH_HUMANMDM2_HUMANBioGRID21093410 26025930 details
ITCH_HUMANGLCM_HUMANBioGRID23255161 details
ITCH_HUMANMGRN1_HUMANBioGRID23253940 details
ITCH_HUMANNOTC1_HUMANBioGRID, HPRD12682059 23886940 details
ITCH_HUMANWWOX_HUMANBioGRID24550385 25331887 details
ITCH_HUMANSMAD6_HUMANBioGRID24850914 details
ITCH_HUMANHD_HUMANBioGRID24865853 details
ITCH_HUMANATX3_HUMANBioGRID24865853 details
ITCH_HUMANPTC1_HUMANBioGRID25092867 details
ITCH_HUMANGELS_HUMANBioGRID25246592 details
ITCH_HUMANGGA3_HUMANBioGRID25195858 details
ITCH_HUMANNCOA1_HUMANBioGRID16051665 details
ITCH_HUMANM3K7_HUMANBioGRID25632008 details
ITCH_HUMANLRAD3_HUMANBioGRID26854353 details
ITCH_HUMANIKKB_HUMANBioGRID26603838 details
ITCH_HUMANPDC6I_HUMANBioGRID26508657 details
ITCH_HUMANCOIA1_HUMANBioGRID26508657 details
ITCH_HUMANHDAC6_HUMANBioGRID26508657 details
ITCH_HUMANIMA1_HUMANBioGRID26508657 details
ITCH_HUMANLRRK2_HUMANBioGRID26508657 details
ITCH_HUMANPCNA_HUMANBioGRID26508657 details
ITCH_HUMANSCAM3_HUMANBioGRID26508657 details
ITCH_HUMANAAAT_HUMANBioGRID26508657 details
ITCH_HUMAN4F2_HUMANBioGRID26508657 details
ITCH_HUMANUBA1_HUMANBioGRID26508657 details
ITCH_HUMANUBA6_HUMANBioGRID26508657 details
ITCH_HUMANUBP5_HUMANBioGRID26508657 details
ITCH_HUMANWWP1_HUMANBioGRID26508657 details
ITCH_HUMANGEMI8_HUMANBioGRID26908624 details
ITCH_HUMANDDX20_HUMANBioGRID26908624 details
ITCH_HUMANRASF1_HUMANBioGRID27292796 details
ITCH_HUMANMTSS1_HUMANBioGRID28264927 details
ITCH_HUMANOTU1_HUMANBioGRID28416659 details
ITCH_HUMANLRP6_HUMANBioGRID28966723 details
ITCH_HUMANARAF_HUMANBioGRID31015455 details
ITCH_HUMANERBB3_HUMANBioGRID31443721 details
ITCH_HUMANAN13A_HUMANBioGRID31985874 details
ITCH_HUMANTNR1A_HUMANBioGRID32690868 details
ITCH_HUMANBAX_HUMANBioGRID32690868 details
ITCH_HUMANTRPC4_HUMANHPRD17110928 details
ITCH_HUMANTRPV1_HUMANHPRD17110928 details