Entity Details

Primary name IKKB_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionO14920
EntryNameIKKB_HUMAN
FullNameInhibitor of nuclear factor kappa-B kinase subunit beta
TaxID9606
Evidenceevidence at protein level
Length756
SequenceStatuscomplete
DateCreated2001-06-01
DateModified2021-06-02

Ontological Relatives

GenesIKBKB

GO terms

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GOName
GO:0002223 stimulatory C-type lectin receptor signaling pathway
GO:0002479 antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent
GO:0002756 MyD88-independent toll-like receptor signaling pathway
GO:0004672 protein kinase activity
GO:0004674 protein serine/threonine kinase activity
GO:0005524 ATP binding
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0006468 protein phosphorylation
GO:0006954 inflammatory response
GO:0007249 I-kappaB kinase/NF-kappaB signaling
GO:0008384 IkappaB kinase activity
GO:0008385 IkappaB kinase complex
GO:0009615 response to virus
GO:0009898 cytoplasmic side of plasma membrane
GO:0010803 regulation of tumor necrosis factor-mediated signaling pathway
GO:0016032 viral process
GO:0018105 peptidyl-serine phosphorylation
GO:0019901 protein kinase binding
GO:0030866 cortical actin cytoskeleton organization
GO:0033209 tumor necrosis factor-mediated signaling pathway
GO:0035509 negative regulation of myosin-light-chain-phosphatase activity
GO:0035631 CD40 receptor complex
GO:0035666 TRIF-dependent toll-like receptor signaling pathway
GO:0038095 Fc-epsilon receptor signaling pathway
GO:0042325 regulation of phosphorylation
GO:0042802 identical protein binding
GO:0042803 protein homodimerization activity
GO:0043066 negative regulation of apoptotic process
GO:0043123 positive regulation of I-kappaB kinase/NF-kappaB signaling
GO:0045087 innate immune response
GO:0045121 membrane raft
GO:0045893 positive regulation of transcription, DNA-templated
GO:0045944 positive regulation of transcription by RNA polymerase II
GO:0046982 protein heterodimerization activity
GO:0050852 T cell receptor signaling pathway
GO:0051092 positive regulation of NF-kappaB transcription factor activity
GO:0051403 stress-activated MAPK cascade
GO:0070498 interleukin-1-mediated signaling pathway
GO:0071356 cellular response to tumor necrosis factor
GO:0072659 protein localization to plasma membrane
GO:0097110 scaffold protein binding
GO:0106310 protein serine kinase activity
GO:0106311 protein threonine kinase activity
GO:1903140 regulation of establishment of endothelial barrier
GO:1903347 negative regulation of bicellular tight junction assembly
GO:1990459 transferrin receptor binding

Subcellular Location

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Subcellular Location
Cytoplasm
Membrane raft
Nucleus

Domains

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DomainNameCategoryType
IPR000626 Ubiquitin-like domainDomainDomain
IPR000719 Protein kinase domainDomainDomain
IPR008271 Serine/threonine-protein kinase, active siteSiteActive site
IPR011009 Protein kinase-like domain superfamilyFamilyHomologous superfamily
IPR022007 I-kappa-kinase-beta NEMO binding domainDomainDomain
IPR029071 Ubiquitin-like domain superfamilyFamilyHomologous superfamily
IPR041185 IKBKB, scaffold dimerization domainDomainDomain

Diseases

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Drugs

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DrugNameSourceType
DB00244 MesalazineDrugbanksmall molecule
DB00795 SulfasalazineDrugbanksmall molecule
DB00945 Acetylsalicylic acidDrugbanksmall molecule
DB00995 AuranofinDrugbanksmall molecule
DB01169 Arsenic trioxideDrugbanksmall molecule
DB05183 MLN0415Drugbanksmall molecule
DB06151 AcetylcysteineDrugbanksmall molecule
DB06521 ErtiprotafibDrugbanksmall molecule
DB12010 FostamatinibDrugbanksmall molecule

Interactions

188 interactions

InteractorPartnerSourcesPublicationsLink
IKKB_HUMANIKKA_HUMANBioGRID, HPRD, IntAct, MINT, UniProt10733566 10968790 11057907 11080499 11585904 11864612 11971985 12210728 12244103 12486103 14743216 16129692 16286467 16319058 17693255 20434986 20932476 21575199 21784860 21903422 23016877 25241761 25748427 25852190 28514442 30500824 9346241 9346484 9346485 9721103 9751060 9914500 details
IKKB_HUMANCBP_HUMANBioGRID, IntAct, UniProt11971985 14597638 25241761 details
IKKB_HUMANNEMO_HUMANBioGRID, DIP, HPRD, InnateDB, IntAct, MINT, UniProt10968790 10980203 11057907 11864612 11971985 12133833 12459277 12486103 12612076 12657630 14743216 15184390 15749833 15802604 16126728 16129692 16319058 16497931 16547522 16583354 16603398 16611882 16906147 16938294 17000764 17363973 17568778 17693255 17977820 18037881 18207244 18266324 18266467 18450452 18462684 18583959 18949366 19365808 19422324 19656241 19666608 19706536 19815509 19820708 19959994 20098747 20167598 20211142 20368414 20434986 20932476 21423167 21455180 21803029 21903422 22099304 22605335 22990857 23016877 23104095 23131831 23506214 23986494 24240172 24266532 24469399 24618592 25286246 25304104 25400026 25852190 25979343 26496610 26500060 27426725 27929056 28249776 28514442 29111346 29474632 30404796 30500824 30561431 30913450 31145594 31932854 32024699 32731169 9751060 details
IKKB_HUMANIKKB_HUMANBioGRID, DIP, HPRD, IntAct10195894 10807933 11585904 12709429 12890679 14743216 16319058 17079871 17939994 21423167 23776406 23792959 24611898 24912152 25486864 29111346 30500824 9346485 9721103 9914500 details
IKKB_HUMANIKBA_HUMANBioGRID, DIP, HPRD, InnateDB, IntAct, MINT, UniProt11080499 12054687 12411322 12486103 12624112 12709429 12943667 14743216 15125833 15125834 15217903 15218148 15456896 15919917 16126728 16286467 16291755 16319058 16365431 16611882 17079871 17363905 18202307 18375836 18519641 18593939 18981174 19196987 19345327 19959994 20434986 20449947 20797629 21399639 21423167 21765415 22022389 22037600 22904686 22990857 23816567 24469399 24611898 24618592 24912152 25595906 25759022 26221961 26740240 26802121 27387502 27497262 28214532 29650758 29958295 30254148 32555320 9346485 9520446 9689078 9721103 9751059 9891086 9914500 details
IKKB_HUMANSRC_HUMANBioGRID, HPRD, IntAct12645577 12707358 15456896 15749833 details
IKKB_HUMANM3K7_HUMANBioGRID, HPRD, MINT10022904 10195894 10779355 10807933 11460167 17363905 17363973 18316610 18456659 20932476 21331078 24270572 25946971 26334375 27387502 27693634 31127032 32410369 9689078 details
IKKB_HUMANSQSTM_HUMANBioGRID, MINT19959994 29474632 details
IKKB_HUMANFOXO3_HUMANBioGRID, HPRD, IntAct15084260 25241761 details
IKKB_HUMANCSN3_HUMANBioGRID19656241 23636414 details
IKKB_HUMANIKBB_HUMANBioGRID, HPRD, IntAct14743216 9346485 9689078 9721103 details
IKKB_HUMANM3K14_HUMANBioGRID, HPRD, IntAct10195894 10733566 11278268 14743216 16286467 28514442 30833792 9346485 9520446 details
IKKB_HUMANTRAF2_HUMANBioGRID, HPRD, IntAct11359906 18362886 19150425 20449947 21782231 23007157 25241761 27387502 32024699 details
IKKB_HUMANTNR1A_HUMANBioGRID, HPRD, IntAct10755617 11002417 11821416 18949366 21331078 21724995 25241761 30420664 31406107 details
IKKB_HUMANCSF2R_HUMANBioGRID, HPRD, IntAct12637324 25241761 details
IKKB_HUMANNFKB1_HUMANBioGRID, HPRD, IntAct10469655 11158290 11297557 11976329 12482991 22536447 25241761 details
IKKB_HUMANCTNB1_HUMANBioGRID, HPRD, IntAct11527961 25241761 details
IKKB_HUMANRO52_HUMANBioGRID19675099 29667579 details
IKKB_HUMANTAB2_HUMANBioGRID21811235 details
IKKB_HUMANNCOA3_HUMANBioGRID, HPRD, UniProt11971985 15383283 16051665 16135815 details
IKKB_HUMANTF65_HUMANBioGRID, HPRD, IntAct, MINT10521409 12842894 15489227 16046471 18519641 22689577 25241761 29084252 details
IKKB_HUMANM3K1_HUMANBioGRID, IntAct11057907 16286467 9819420 details
IKKB_HUMANTRI27_HUMANBioGRID16393995 details
IKKB_HUMANIL3RB_HUMANBioGRID12637324 details
IKKB_HUMANKEAP1_HUMANBioGRID, IntAct19818716 20600852 24322982 25926686 27387502 30126895 30500824 details
IKKB_HUMANBCL10_HUMANBioGRID, DIP11113112 14695475 17213322 19118383 details
IKKB_HUMANAURKA_HUMANBioGRID, DIP17939994 details
IKKB_HUMANP73_HUMANBioGRID21482671 details
IKKB_HUMANCDC37_HUMANBioGRID, HPRD, IntAct11864612 14743216 21903422 25036637 26496610 details
IKKB_HUMANP53_HUMANBioGRID, DIP, MINT19196987 19883646 details
IKKB_HUMANAP2C_HUMANBioGRID, IntAct21988832 details
IKKB_HUMANPPM1B_HUMANBioGRID, HPRD14585847 details
IKKB_HUMANM3K11_HUMANBioGRID, HPRD10713178 details
IKKB_HUMANCSN5_HUMANBioGRID19656241 23636414 31950832 details
IKKB_HUMANRIPK1_HUMANBioGRID10980203 21606198 details
IKKB_HUMANKPCE_HUMANBioGRID23123196 details
IKKB_HUMANSASH1_HUMANBioGRID23776175 30480076 details
IKKB_HUMANTNAP3_HUMANBioGRID, DIP, HPRD11594795 21220427 26649818 details
IKKB_HUMANCUED2_HUMANBioGRID18362886 details
IKKB_HUMANKPCI_HUMANBioGRID10022904 details
IKKB_HUMANJUN_HUMANBioGRID19656241 details
IKKB_HUMANFAF1_HUMANBioGRID17684021 details
IKKB_HUMANTSC1_HUMANBioGRID, IntAct17693255 details
IKKB_HUMANPCNA_HUMANUniProt26030842 details
IKKB_HUMANP2R3C_HUMANBioGRID20925653 details
IKKB_HUMANPLK1_HUMANBioGRID18957422 details
IKKB_HUMANMAVS_HUMANBioGRID, IntAct, UniProt16177806 21782231 25636800 details
IKKB_HUMANFANCA_HUMANBioGRID, HPRD12210728 details
IKKB_HUMANCSN7A_HUMANBioGRID19656241 details
IKKB_HUMANEGLN3_HUMANBioGRID19786027 23732909 details
IKKB_HUMANE2F4_HUMANBioGRID18542057 details
IKKB_HUMANSTAP2_HUMANBioGRID, HPRD, IntAct16365431 details
IKKB_HUMANIKKE_HUMANBioGRID23453969 9914500 details
IKKB_HUMANJPH3_HUMANIntAct32814053 details
IKKB_HUMANPELI1_HUMANBioGRID21204785 details
IKKB_HUMANTRAF1_HUMANBioGRID12709429 20856938 details
IKKB_HUMANUBC_HUMANBioGRID28190767 details
IKKB_HUMANPRKDC_HUMANBioGRID9632806 details
IKKB_HUMANKPCD_HUMANBioGRID10022904 details
IKKB_HUMANNED4L_HUMANBioGRID18981174 details
IKKB_HUMANKLH21_HUMANBioGRID27387502 details
IKKB_HUMANCSN4_HUMANBioGRID19656241 details
IKKB_HUMANGLI1_HUMANBioGRID26603838 details
IKKB_HUMANRS3_HUMANInnateDB21399639 details
IKKB_HUMANKPCA_HUMANBioGRID10022904 details
IKKB_HUMANPPARG_HUMANBioGRID19596656 details
IKKB_HUMANVHL_HUMANBioGRID27693634 details
IKKB_HUMANHOME3_HUMANBioGRID20693425 details
IKKB_HUMANROCK1_HUMANBioGRID24240172 details
IKKB_HUMANRICTR_HUMANBioGRID23872070 details
IKKB_HUMANTWST1_HUMANBioGRID23375009 details
IKKB_HUMANSKP2_HUMANBioGRID29474632 details
IKKB_HUMANHD_HUMANBioGRID20026656 details
IKKB_HUMANNAA20_HUMANBioGRID19716809 details
IKKB_HUMANMARK3_HUMANMINT17363905 details
IKKB_HUMANM3K13_HUMANBioGRID, HPRD12492477 details
IKKB_HUMANMACD1_HUMANBioGRID25735744 details
IKKB_HUMANLATS2_HUMANBioGRID25946971 details
IKKB_HUMANUBP18_HUMANBioGRID26240016 details
IKKB_HUMANATM_HUMANBioGRID32731169 details
IKKB_HUMANHSP7C_HUMANIntAct14743216 details
IKKB_HUMANGRP75_HUMANIntAct14743216 details
IKKB_HUMANZC12A_HUMANInnateDB22037600 details
IKKB_HUMANTPX2_HUMANBioGRID, DIP17939994 details
IKKB_HUMANTANK_HUMANBioGRID, HPRD, IntAct12133833 30561431 details
IKKB_HUMANTNFA_HUMANBioGRID16603398 20005846 27307491 27545878 details
IKKB_HUMANBCL2_HUMANBioGRID22262057 details
IKKB_HUMANSMN_HUMANBioGRID28214532 details
IKKB_HUMANLYSC_HUMANIntAct14743216 details
IKKB_HUMANFBW1A_HUMANBioGRID11158290 19656241 20797629 details
IKKB_HUMANTRI40_HUMANBioGRID21474709 details
IKKB_HUMANCLH1_HUMANBioGRID, IntAct14743216 25241761 details
IKKB_HUMANPRDX3_HUMANBioGRID12492477 details
IKKB_HUMANIRS1_HUMANBioGRID, HPRD10722755 11606564 12351658 details
IKKB_HUMANNLRX1_HUMANBioGRID21703539 details
IKKB_HUMANIFIT5_HUMANBioGRID26334375 details
IKKB_HUMAN1433B_HUMANHPRD16024783 details
IKKB_HUMANFLNA_HUMANIntAct14743216 details
IKKB_HUMANTNIP2_HUMANBioGRID, IntAct21784860 30561431 details
IKKB_HUMANCDN2A_HUMANBioGRID20152798 details
IKKB_HUMANTNR5_HUMANBioGRID20614026 details
IKKB_HUMANMYH10_HUMANIntAct14743216 details
IKKB_HUMANHNRPU_HUMANBioGRID, IntAct14743216 20797629 details
IKKB_HUMANHS90B_HUMANBioGRID, HPRD, IntAct14743216 25241761 details
IKKB_HUMANKPCB_HUMANBioGRID, HPRD, IntAct12070292 25241761 details
IKKB_HUMANAKT1_HUMANBioGRID, HPRD, IntAct10485711 15856005 22689577 25241761 details
IKKB_HUMANCIKS_HUMANBioGRID, HPRD10962033 12943667 24561578 details
IKKB_HUMANTAB1_HUMANBioGRID18316610 details
IKKB_HUMANTNR16_HUMANBioGRID23017601 details
IKKB_HUMANEPAS1_HUMANBioGRID26500060 details
IKKB_HUMANPEBP1_HUMANHPRD11585904 details
IKKB_HUMANRB6I2_HUMANBioGRID15218148 20932476 details
IKKB_HUMANMK14_HUMANBioGRID20797629 details
IKKB_HUMANKPCT_HUMANBioGRID, HPRD11120819 15802604 17363905 20164171 details
IKKB_HUMANELP1_HUMANBioGRID, HPRD9751059 details
IKKB_HUMANARF_HUMANBioGRID20152798 details
IKKB_HUMANRPTOR_HUMANBioGRID18519641 23872070 details
IKKB_HUMANANGL8_HUMANBioGRID29255244 details
IKKB_HUMANCFLAR_HUMANHPRD11002417 details
IKKB_HUMANTBB4A_HUMANIntAct14743216 details
IKKB_HUMANPP2AA_HUMANBioGRID, MINT16126728 16129692 details
IKKB_HUMANPP1A_HUMANBioGRID18362886 18949366 details
IKKB_HUMANCUL1_HUMANBioGRID19656241 details
IKKB_HUMANBRAP_HUMANBioGRID21670849 details
IKKB_HUMANCCAR2_HUMANHPRD, IntAct14743216 details
IKKB_HUMANTNIK_HUMANBioGRID, DIP22904686 details
IKKB_HUMANIRAK1_HUMANBioGRID11096118 18180283 details
IKKB_HUMANSYEP_HUMANIntAct14743216 details
IKKB_HUMANNBR1_HUMANBioGRID29474632 details
IKKB_HUMANTFR1_HUMANBioGRID23016877 details
IKKB_HUMANHS71L_HUMANIntAct14743216 details
IKKB_HUMANTIM50_HUMANIntAct14743216 details
IKKB_HUMANTBK1_HUMANHPRD, IntAct14560022 21782231 details
IKKB_HUMANASC_HUMANBioGRID, UniProt12486103 details
IKKB_HUMANPR15A_HUMANBioGRID18362886 details
IKKB_HUMANMUC1_HUMANBioGRID18037881 details
IKKB_HUMANP63_HUMANBioGRID20145131 details
IKKB_HUMANBNI3L_HUMANBioGRID29474632 details
IKKB_HUMANVIME_HUMANBioGRID22536447 details
IKKB_HUMANUBB_HUMANHPRD16267042 details
IKKB_HUMANNR2C2_HUMANHPRD12547194 details
IKKB_HUMANTBA3D_HUMANIntAct14743216 details
IKKB_HUMANNFKB2_HUMANHPRD, IntAct14743216 details
IKKB_HUMANCUL3_HUMANBioGRID19818716 details
IKKB_HUMANSTK26_HUMANBioGRID25642822 details
IKKB_HUMANITCH_HUMANBioGRID26603838 details
IKKB_HUMANCACO2_HUMANBioGRID29474632 details
IKKB_HUMANIQGA1_HUMANIntAct14743216 details
IKKB_HUMANCASP8_HUMANBioGRID, HPRD11002417 details
IKKB_HUMANMTOR_HUMANBioGRID18490760 18519641 details
IKKB_HUMANMARH2_HUMANBioGRID32935379 details
IKKB_HUMANM3K3_HUMANHPRD, IntAct11429546 14743216 details
IKKB_HUMANHS90A_HUMANBioGRID, HPRD, IntAct11864612 14743216 19786027 details
IKKB_HUMANTRAF6_HUMANBioGRID, IntAct16920630 21782231 details
IKKB_HUMANTPPC9_HUMANBioGRID15951441 details
IKKB_HUMANMEOX2_HUMANBioGRID20421348 details
IKKB_HUMANPP4C_HUMANBioGRID27391343 details
IKKB_HUMANTP4AP_HUMANBioGRID, HPRD14585990 32889079 details
IKKB_HUMANTAB3_HUMANBioGRID27497262 details
IKKB_HUMANKPCZ_HUMANHPRD10022904 10195894 10779355 9689078 details
IKKB_HUMANCOMD7_HUMANBioGRID26060140 details
IKKB_HUMANOPTN_HUMANBioGRID29474632 details
IKKB_HUMANTBA3C_HUMANIntAct14743216 details
IKKB_HUMANUBP4_HUMANBioGRID21331078 details
IKKB_HUMANLRC14_HUMANBioGRID27426725 details
IKKB_HUMANE2AK3_HUMANHPRD10848580 details
IKKB_HUMANSMRC1_HUMANIntAct14743216 details
IKKB_HUMANCALM2_HUMANIntAct14743216 details
IKKB_HUMANM3K21_HUMANIntAct26859459 details
IKKB_HUMANHIF1A_HUMANBioGRID26500060 details
IKKB_HUMANPARP1_HUMANIntAct14743216 details
IKKB_HUMANE2AK2_HUMANBioGRID, HPRD10848580 details
IKKB_HUMANRNF8_HUMANBioGRID28499869 details
IKKB_HUMANPP4R1_HUMANBioGRID27391343 details
IKKB_HUMANBIP_HUMANIntAct14743216 details
IKKB_HUMANCSK2B_HUMANBioGRID20797629 details
IKKB_HUMANTOLIP_HUMANBioGRID29474632 details
IKKB_HUMANACVR1_HUMANHPRD15761153 details
IKKB_HUMANTBB2B_HUMANIntAct14743216 details
IKKB_HUMANDUS1_HUMANBioGRID10022904 details
IKKB_HUMANNALP2_HUMANBioGRID15456791 details
IKKB_HUMANDPP4_HUMANBioGRID17287217 details
IKKB_HUMANC1QBP_HUMANIntAct14743216 details
IKKB_HUMANACTG_HUMANIntAct14743216 details
IKKB_HUMANTBB5_HUMANIntAct14743216 details
IKKB_HUMANHSPB1_HUMANBioGRID16840786 details
IKKB_HUMANPP4R2_HUMANBioGRID27391343 details
IKKB_HUMANTGFR1_HUMANHPRD15761153 details