Entity Details

Primary name S27A2_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionO14975
EntryNameS27A2_HUMAN
FullNameVery long-chain acyl-CoA synthetase
TaxID9606
Evidenceevidence at protein level
Length620
SequenceStatuscomplete
DateCreated1998-07-15
DateModified2021-06-02

Ontological Relatives

GenesSLC27A2

GO terms

Show/Hide Table
GOName
GO:0001561 fatty acid alpha-oxidation
GO:0001676 long-chain fatty acid metabolic process
GO:0004467 long-chain fatty acid-CoA ligase activity
GO:0005324 long-chain fatty acid transporter activity
GO:0005524 ATP binding
GO:0005778 peroxisomal membrane
GO:0005779 integral component of peroxisomal membrane
GO:0005783 endoplasmic reticulum
GO:0005788 endoplasmic reticulum lumen
GO:0005789 endoplasmic reticulum membrane
GO:0005829 cytosol
GO:0005886 plasma membrane
GO:0006635 fatty acid beta-oxidation
GO:0006699 bile acid biosynthetic process
GO:0008104 protein localization
GO:0015245 fatty acid transmembrane transporter activity
GO:0019899 enzyme binding
GO:0030176 integral component of endoplasmic reticulum membrane
GO:0031957 very long-chain fatty acid-CoA ligase activity
GO:0035579 specific granule membrane
GO:0042760 very long-chain fatty acid catabolic process
GO:0043312 neutrophil degranulation
GO:0044539 long-chain fatty acid import into cell
GO:0047676 arachidonate-CoA ligase activity
GO:0047747 cholate-CoA ligase activity
GO:0050197 phytanate-CoA ligase activity
GO:0070062 extracellular exosome
GO:0070251 pristanate-CoA ligase activity
GO:0097089 methyl-branched fatty acid metabolic process

Subcellular Location

Show/Hide Table
Subcellular Location
Cell membrane
Endoplasmic reticulum membrane
Microsome
Peroxisome membrane

Domains

Show/Hide Table
DomainNameCategoryType
IPR000873 AMP-dependent synthetase/ligaseDomainDomain
IPR020845 AMP-binding, conserved siteSiteConserved site
IPR025110 AMP-binding enzyme, C-terminal domainDomainDomain
IPR030305 Fatty acid transport protein 2FamilyFamily
IPR042099 ANL, N-terminal domainFamilyHomologous superfamily

Diseases

Show/Hide Table

Drugs

Show/Hide Table
DrugNameSourceType
DB11936 Bempedoic acidDrugbanksmall molecule