Entity Details

Primary name PNKP_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionQ96T60
EntryNamePNKP_HUMAN
FullNameBifunctional polynucleotide phosphatase/kinase
TaxID9606
Evidenceevidence at protein level
Length521
SequenceStatuscomplete
DateCreated2004-07-19
DateModified2021-06-02

Ontological Relatives

GenesPNKP

GO terms

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GOName
GO:0000718 nucleotide-excision repair, DNA damage removal
GO:0003684 damaged DNA binding
GO:0003690 double-stranded DNA binding
GO:0004519 endonuclease activity
GO:0005524 ATP binding
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005730 nucleolus
GO:0005739 mitochondrion
GO:0006261 DNA-dependent DNA replication
GO:0006281 DNA repair
GO:0006287 base-excision repair, gap-filling
GO:0006979 response to oxidative stress
GO:0009314 response to radiation
GO:0010836 negative regulation of protein ADP-ribosylation
GO:0016020 membrane
GO:0016311 dephosphorylation
GO:0017076 purine nucleotide binding
GO:0032212 positive regulation of telomere maintenance via telomerase
GO:0042769 DNA damage response, detection of DNA damage
GO:0046403 polynucleotide 3'-phosphatase activity
GO:0046404 polydeoxyribonucleotide 5'-hydroxyl-kinase activity
GO:0046939 nucleotide phosphorylation
GO:0051973 positive regulation of telomerase activity
GO:1904355 positive regulation of telomere capping
GO:2001034 positive regulation of double-strand break repair via nonhomologous end joining

Subcellular Location

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Subcellular Location
Nucleus

Domains

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DomainNameCategoryType
IPR006549 HAD-superfamily hydrolase,subfamily IIIADomainDomain
IPR006550 Bifunctional polynucleotide phosphatase/kinase PNKPFamilyFamily
IPR006551 Polynucleotide 3'-phosphataseDomainDomain
IPR008984 SMAD/FHA domain superfamilyFamilyHomologous superfamily
IPR013954 Polynucleotide kinase 3 phosphataseFamilyFamily
IPR023214 HAD superfamilyFamilyHomologous superfamily
IPR027417 P-loop containing nucleoside triphosphate hydrolaseFamilyHomologous superfamily
IPR036412 HAD-like superfamilyFamilyHomologous superfamily
IPR041388 PNK, FHA domainDomainDomain

Diseases

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Interactions

83 interactions

InteractorPartnerSourcesPublicationsLink
PNKP_HUMANXRCC4_HUMANBioGRID, HPRD, IntAct, MINT15385968 17353931 21637298 26186194 28514442 32296183 details
PNKP_HUMANSMAD5_HUMANBioGRID, HPRD, MINT15231748 details
PNKP_HUMANKR412_HUMANBioGRID, HPRD, IntAct16189514 details
PNKP_HUMANMYOZ1_HUMANBioGRID, HPRD, IntAct16189514 details
PNKP_HUMANTRI37_HUMANBioGRID, HPRD, IntAct16189514 32296183 details
PNKP_HUMANMAGAB_HUMANBioGRID, HPRD, IntAct16189514 details
PNKP_HUMANXRCC1_HUMANBioGRID, HPRD, IntAct, MINT11163244 15367657 15385968 17353931 19155274 21637298 26496610 details
PNKP_HUMANDNLI3_HUMANBioGRID, IntAct11163244 17353931 30994454 details
PNKP_HUMANGRAK_HUMANBioGRID, IntAct21988832 details
PNKP_HUMANSUV91_HUMANBioGRID, MINT23455924 details
PNKP_HUMANKDM1A_HUMANBioGRID, MINT23455924 details
PNKP_HUMANZBT14_HUMANBioGRID, IntAct25416956 32296183 details
PNKP_HUMANIKZF1_HUMANBioGRID, IntAct25416956 32296183 details
PNKP_HUMANTNIP1_HUMANBioGRID, IntAct25416956 32296183 details
PNKP_HUMANZN639_HUMANBioGRID, IntAct25416956 32296183 details
PNKP_HUMANDVL3_HUMANBioGRID, IntAct32296183 details
PNKP_HUMANKANK2_HUMANBioGRID, IntAct32296183 details
PNKP_HUMANCAR10_HUMANBioGRID, IntAct32296183 details
PNKP_HUMANPICK1_HUMANBioGRID, IntAct32296183 details
PNKP_HUMANTHAP1_HUMANBioGRID, IntAct32296183 details
PNKP_HUMANKLH12_HUMANBioGRID, IntAct32296183 details
PNKP_HUMANTM239_HUMANBioGRID, IntAct32296183 details
PNKP_HUMANCISD2_HUMANBioGRID, IntAct32296183 details
PNKP_HUMANSYPH_HUMANBioGRID, IntAct32296183 details
PNKP_HUMANFADS6_HUMANBioGRID, IntAct32296183 details
PNKP_HUMANSNG1_HUMANBioGRID, IntAct32296183 details
PNKP_HUMANCOHA1_HUMANBioGRID, IntAct32296183 details
PNKP_HUMANCNTRB_HUMANBioGRID, IntAct32296183 details
PNKP_HUMANCCD14_HUMANBioGRID, IntAct32296183 details
PNKP_HUMANPNMA5_HUMANBioGRID, IntAct32296183 details
PNKP_HUMANSP4_HUMANBioGRID, IntAct32296183 details
PNKP_HUMANPPIP1_HUMANBioGRID, IntAct32296183 details
PNKP_HUMANMSD4_HUMANBioGRID, IntAct32296183 details
PNKP_HUMANCRCM_HUMANBioGRID, IntAct32296183 details
PNKP_HUMANTRBP2_HUMANBioGRID, IntAct32296183 details
PNKP_HUMANKCC2B_HUMANBioGRID, IntAct32296183 details
PNKP_HUMANTBCD1_HUMANBioGRID, IntAct32296183 details
PNKP_HUMANDRC4_HUMANBioGRID, IntAct32296183 details
PNKP_HUMANRPRM_HUMANBioGRID, IntAct32296183 details
PNKP_HUMANMGST2_HUMANBioGRID, IntAct32296183 details
PNKP_HUMANSNX2_HUMANBioGRID, IntAct32296183 details
PNKP_HUMANSFT2A_HUMANBioGRID, IntAct32296183 details
PNKP_HUMANSNG3_HUMANBioGRID, IntAct32296183 details
PNKP_HUMANFLOWR_HUMANBioGRID, IntAct32296183 details
PNKP_HUMANDPOLB_HUMANBioGRID, IntAct11163244 26186194 28514442 details
PNKP_HUMANCCD43_HUMANBioGRID, IntAct26186194 28514442 32296183 details
PNKP_HUMANCLAT_HUMANIntAct32814053 details
PNKP_HUMANFGFR3_HUMANIntAct32814053 details
PNKP_HUMANUBQL1_HUMANIntAct32814053 details
PNKP_HUMANA4_HUMANBioGRID21832049 details
PNKP_HUMANATX3_HUMANBioGRID25590633 30994454 details
PNKP_HUMANLMNA_HUMANBioGRID24623722 details
PNKP_HUMANMEOX2_HUMANBioGRID32296183 details
PNKP_HUMANOBI1_HUMANBioGRID32296183 details
PNKP_HUMANOGT1_HUMANBioGRID32994395 details
PNKP_HUMAN1433Z_HUMANIntAct17353931 details
PNKP_HUMANDNLI4_HUMANBioGRID, IntAct15385968 17353931 details
PNKP_HUMANMCM3_HUMANBioGRID, IntAct15385968 17353931 details
PNKP_HUMANTP53B_HUMANMINT21637298 details
PNKP_HUMANCR025_HUMANBioGRID15385968 details
PNKP_HUMANTRI26_HUMANBioGRID15385968 details
PNKP_HUMANNASP_HUMANBioGRID15385968 details
PNKP_HUMANXRCC6_HUMANBioGRID15385968 details
PNKP_HUMANXRCC5_HUMANBioGRID15385968 details
PNKP_HUMANSSRP1_HUMANBioGRID15385968 details
PNKP_HUMANMCM5_HUMANBioGRID15385968 details
PNKP_HUMANGEMI4_HUMANBioGRID15385968 details
PNKP_HUMANCD11B_HUMANBioGRID15385968 details
PNKP_HUMANPARP1_HUMANBioGRID15385968 details
PNKP_HUMANHNRPU_HUMANBioGRID15385968 details
PNKP_HUMANNOLC1_HUMANBioGRID15385968 details
PNKP_HUMANSP16H_HUMANBioGRID15385968 details
PNKP_HUMANNRDC_HUMANBioGRID15385968 details
PNKP_HUMANCBPC1_HUMANBioGRID15385968 details
PNKP_HUMANTCOF_HUMANBioGRID15385968 details
PNKP_HUMANDCAF1_HUMANBioGRID15385968 details
PNKP_HUMANUBE2O_HUMANBioGRID15385968 details
PNKP_HUMANPRKDC_HUMANBioGRID15385968 details
PNKP_HUMANHD_HUMANBioGRID30994454 details
PNKP_HUMANHAP1_HUMANBioGRID30994454 details
PNKP_HUMANRPB1_HUMANBioGRID30994454 details
PNKP_HUMANCBP_HUMANBioGRID30994454 details
PNKP_HUMANTAF4_HUMANBioGRID30994454 details