Entity Details

Primary name SETB2_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionQ96T68
EntryNameSETB2_HUMAN
FullNameHistone-lysine N-methyltransferase SETDB2
TaxID9606
Evidenceevidence at protein level
Length719
SequenceStatuscomplete
DateCreated2003-10-03
DateModified2021-06-02

Ontological Relatives

GenesSETDB2

GO terms

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GOName
GO:0000278 mitotic cell cycle
GO:0001947 heart looping
GO:0003677 DNA binding
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005694 chromosome
GO:0005829 cytosol
GO:0007059 chromosome segregation
GO:0008270 zinc ion binding
GO:0010629 negative regulation of gene expression
GO:0045892 negative regulation of transcription, DNA-templated
GO:0046974 histone methyltransferase activity (H3-K9 specific)
GO:0051301 cell division
GO:0051567 histone H3-K9 methylation
GO:0070828 heterochromatin organization
GO:0070986 left/right axis specification
GO:0090309 positive regulation of DNA methylation-dependent heterochromatin assembly

Subcellular Location

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Subcellular Location
Chromosome
Nucleus

Domains

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DomainNameCategoryType
IPR001214 SET domainDomainDomain
IPR001739 Methyl-CpG DNA bindingDomainDomain
IPR007728 Pre-SET domainDomainDomain
IPR016177 DNA-binding domain superfamilyFamilyHomologous superfamily

Diseases

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Interactions

1 interaction

InteractorPartnerSourcesPublicationsLink
SETB2_HUMANAL14E_HUMANBioGRID, IntAct25416956 28514442 31515488 32296183 details