Entity Details

Primary name UHRF1_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionQ96T88
EntryNameUHRF1_HUMAN
FullNameE3 ubiquitin-protein ligase UHRF1
TaxID9606
Evidenceevidence at protein level
Length793
SequenceStatuscomplete
DateCreated2005-06-07
DateModified2021-06-02

Ontological Relatives

GenesUHRF1

GO terms

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GOName
GO:0000122 negative regulation of transcription by RNA polymerase II
GO:0000785 chromatin
GO:0000791 euchromatin
GO:0000792 heterochromatin
GO:0000987 cis-regulatory region sequence-specific DNA binding
GO:0004842 ubiquitin-protein transferase activity
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005657 replication fork
GO:0006281 DNA repair
GO:0006511 ubiquitin-dependent protein catabolic process
GO:0007049 cell cycle
GO:0008270 zinc ion binding
GO:0008327 methyl-CpG binding
GO:0010216 maintenance of DNA methylation
GO:0010390 histone monoubiquitination
GO:0016363 nuclear matrix
GO:0016567 protein ubiquitination
GO:0016574 histone ubiquitination
GO:0031493 nucleosomal histone binding
GO:0032270 positive regulation of cellular protein metabolic process
GO:0035064 methylated histone binding
GO:0042393 histone binding
GO:0042802 identical protein binding
GO:0044729 hemi-methylated DNA-binding
GO:0045944 positive regulation of transcription by RNA polymerase II
GO:0050678 regulation of epithelial cell proliferation
GO:0051865 protein autoubiquitination
GO:0061630 ubiquitin protein ligase activity
GO:2000373 positive regulation of DNA topoisomerase (ATP-hydrolyzing) activity

Subcellular Location

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Subcellular Location
Nucleus

Domains

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DomainNameCategoryType
IPR000626 Ubiquitin-like domainDomainDomain
IPR001841 Zinc finger, RING-typeDomainDomain
IPR001965 Zinc finger, PHD-typeDomainDomain
IPR003105 SRA-YDGDomainDomain
IPR011011 Zinc finger, FYVE/PHD-typeFamilyHomologous superfamily
IPR013083 Zinc finger, RING/FYVE/PHD-typeFamilyHomologous superfamily
IPR015947 PUA-like superfamilyFamilyHomologous superfamily
IPR017907 Zinc finger, RING-type, conserved siteSiteConserved site
IPR019787 Zinc finger, PHD-fingerDomainDomain
IPR021991 UHRF1, tandem tudor domainDomainDomain
IPR029071 Ubiquitin-like domain superfamilyFamilyHomologous superfamily
IPR036987 SRA-YDG superfamilyFamilyHomologous superfamily

Diseases

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Interactions

56 interactions

InteractorPartnerSourcesPublicationsLink
UHRF1_HUMANDNMT1_HUMANBioGRID, IntAct, MINT17673620 17934516 19798101 19800870 19943104 20613874 21045206 21268065 21745816 22064703 24368767 24782312 26065575 27045799 27049577 28803780 29268763 29691401 31322780 details
UHRF1_HUMANDNM3A_HUMANBioGRID, MINT19798101 21745816 22064703 details
UHRF1_HUMANPCNA_HUMANBioGRID, IntAct26496610 30357346 details
UHRF1_HUMANUBP7_HUMANBioGRID, IntAct21268065 21745816 22411829 23297342 24013172 26046769 26299963 26496610 28803780 32884836 details
UHRF1_HUMANFBW1A_HUMANBioGRID, IntAct23297342 26768845 28514442 details
UHRF1_HUMANH31_HUMANBioGRID, HPRD, MINT14993289 17967883 22064703 25281560 29506131 30392931 30639225 31018966 32144273 32428527 32609811 34079125 details
UHRF1_HUMANKAT5_HUMANBioGRID19800870 21045206 23677994 29268763 details
UHRF1_HUMANUHRF2_HUMANBioGRID22411829 30335751 details
UHRF1_HUMANH32_HUMANBioGRID21489993 22294699 22837395 23022729 details
UHRF1_HUMANKAPCA_HUMANBioGRID15178447 details
UHRF1_HUMANH31T_HUMANBioGRID22100450 23161542 23281010 23752590 24813945 26065575 27595565 29395786 30104358 details
UHRF1_HUMANUHRF1_HUMANBioGRID17967883 23161542 24782312 26299963 27595565 29506131 30104358 31481468 details
UHRF1_HUMANPARP1_HUMANBioGRID24782312 31964471 34079125 details
UHRF1_HUMANMBD4_HUMANBioGRID25358258 details
UHRF1_HUMANMUS81_HUMANBioGRID25818288 details
UHRF1_HUMANERCC1_HUMANBioGRID25818288 details
UHRF1_HUMANTOP2A_HUMANBioGRID25451918 details
UHRF1_HUMANUB2D3_HUMANBioGRID26299963 27595565 30392931 details
UHRF1_HUMANP53_HUMANBioGRID26102039 details
UHRF1_HUMANERG_HUMANBioGRID27626314 details
UHRF1_HUMANLASP1_HUMANBioGRID25982273 details
UHRF1_HUMANDNLI1_HUMANBioGRID28803780 30639225 32428527 details
UHRF1_HUMANUB2D1_HUMANBioGRID29506131 30104358 31481468 details
UHRF1_HUMANFACD2_HUMANBioGRID30335751 31180492 details
UHRF1_HUMANSETD7_HUMANBioGRID30357346 details
UHRF1_HUMANUBE2N_HUMANBioGRID30357346 details
UHRF1_HUMANPAF15_HUMANBioGRID32144273 details
UHRF1_HUMANHDAC1_HUMANBioGRID, IntAct15361834 17934516 19800870 22411829 details
UHRF1_HUMANDNM3B_HUMANBioGRID, MINT19798101 22064703 details
UHRF1_HUMANEHMT2_HUMANBioGRID19056828 19943104 22064703 details
UHRF1_HUMANURFB1_HUMANBioGRID15361834 details
UHRF1_HUMANTIF1B_HUMANBioGRID22055183 details
UHRF1_HUMANRNF4_HUMANBioGRID21252943 details
UHRF1_HUMANUBP11_HUMANBioGRID22411829 details
UHRF1_HUMANSUZ12_HUMANBioGRID22330138 details
UHRF1_HUMANEZH2_HUMANBioGRID22330138 27634302 details
UHRF1_HUMANSUV91_HUMANBioGRID22330138 details
UHRF1_HUMANPML_HUMANBioGRID22945642 details
UHRF1_HUMANRB_HUMANBioGRID16007129 details
UHRF1_HUMANCUL1_HUMANBioGRID23297342 details
UHRF1_HUMAN3MG_HUMANBioGRID23537643 details
UHRF1_HUMANPARP2_HUMANBioGRID24782312 details
UHRF1_HUMANXPF_HUMANBioGRID25818288 details
UHRF1_HUMANEME1_HUMANBioGRID25818288 details
UHRF1_HUMANFBW1B_HUMANBioGRID26768845 details
UHRF1_HUMANANM5_HUMANBioGRID26597461 details
UHRF1_HUMANHS71A_HUMANBioGRID27489107 details
UHRF1_HUMANHS71B_HUMANBioGRID27489107 details
UHRF1_HUMANHS90A_HUMANBioGRID27489107 details
UHRF1_HUMANCADH1_HUMANBioGRID29466696 details
UHRF1_HUMANH2B1B_HUMANBioGRID, HPRD14993289 27248496 details
UHRF1_HUMANTCAB1_HUMANBioGRID29516630 details
UHRF1_HUMANKDM1A_HUMANBioGRID30357346 details
UHRF1_HUMANH4_HUMANBioGRID, HPRD14993289 30804502 details
UHRF1_HUMANZN263_HUMANBioGRID32051553 details
UHRF1_HUMANH2A1B_HUMANHPRD14993289 details