Entity Details

Primary name CIB1_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionQ99828
EntryNameCIB1_HUMAN
FullNameCalcium and integrin-binding protein 1
TaxID9606
Evidenceevidence at protein level
Length191
SequenceStatuscomplete
DateCreated1997-11-01
DateModified2021-06-02

Ontological Relatives

GenesCIB1

GO terms

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GOName
GO:0001525 angiogenesis
GO:0001933 negative regulation of protein phosphorylation
GO:0001934 positive regulation of protein phosphorylation
GO:0001954 positive regulation of cell-matrix adhesion
GO:0002931 response to ischemia
GO:0005509 calcium ion binding
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005737 cytoplasm
GO:0005783 endoplasmic reticulum
GO:0005794 Golgi apparatus
GO:0005813 centrosome
GO:0005886 plasma membrane
GO:0006302 double-strand break repair
GO:0006915 apoptotic process
GO:0006974 cellular response to DNA damage stimulus
GO:0007026 negative regulation of microtubule depolymerization
GO:0007113 endomitotic cell cycle
GO:0007155 cell adhesion
GO:0007286 spermatid development
GO:0008022 protein C-terminus binding
GO:0008284 positive regulation of cell population proliferation
GO:0008285 negative regulation of cell population proliferation
GO:0008427 calcium-dependent protein kinase inhibitor activity
GO:0010977 negative regulation of neuron projection development
GO:0016020 membrane
GO:0016324 apical plasma membrane
GO:0019901 protein kinase binding
GO:0030027 lamellipodium
GO:0030220 platelet formation
GO:0030291 protein serine/threonine kinase inhibitor activity
GO:0030307 positive regulation of cell growth
GO:0030335 positive regulation of cell migration
GO:0030425 dendrite
GO:0030426 growth cone
GO:0031122 cytoplasmic microtubule organization
GO:0031267 small GTPase binding
GO:0031982 vesicle
GO:0032433 filopodium tip
GO:0032587 ruffle membrane
GO:0033630 positive regulation of cell adhesion mediated by integrin
GO:0038163 thrombopoietin-mediated signaling pathway
GO:0042127 regulation of cell population proliferation
GO:0042383 sarcolemma
GO:0043005 neuron projection
GO:0043025 neuronal cell body
GO:0043066 negative regulation of apoptotic process
GO:0043085 positive regulation of catalytic activity
GO:0043204 perikaryon
GO:0043495 protein-membrane adaptor activity
GO:0044325 transmembrane transporter binding
GO:0045653 negative regulation of megakaryocyte differentiation
GO:0048471 perinuclear region of cytoplasm
GO:0051092 positive regulation of NF-kappaB transcription factor activity
GO:0051301 cell division
GO:0051302 regulation of cell division
GO:0051898 negative regulation of protein kinase B signaling
GO:0070062 extracellular exosome
GO:0070374 positive regulation of ERK1 and ERK2 cascade
GO:0070886 positive regulation of calcineurin-NFAT signaling cascade
GO:0071356 cellular response to tumor necrosis factor
GO:0071363 cellular response to growth factor stimulus
GO:0071902 positive regulation of protein serine/threonine kinase activity
GO:0071944 cell periphery
GO:0090050 positive regulation of cell migration involved in sprouting angiogenesis
GO:0090314 positive regulation of protein targeting to membrane
GO:0097191 extrinsic apoptotic signaling pathway
GO:1900026 positive regulation of substrate adhesion-dependent cell spreading
GO:1903078 positive regulation of protein localization to plasma membrane
GO:1990090 cellular response to nerve growth factor stimulus
GO:2000256 positive regulation of male germ cell proliferation

Subcellular Location

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Subcellular Location
Apical cell membrane
Cell membrane
Cell projection
Cytoplasm
Golgi apparatus
Membrane
Nucleus
Perikaryon

Domains

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DomainNameCategoryType
IPR002048 EF-hand domainDomainDomain
IPR011992 EF-hand domain pairFamilyHomologous superfamily
IPR018247 EF-Hand 1, calcium-binding siteSiteBinding site

Diseases

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Drugs

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DrugNameSourceType
DB11093 Calcium citrateDrugbanksmall molecule
DB11348 Calcium PhosphateDrugbanksmall molecule
DB14481 Calcium phosphate dihydrateDrugbanksmall molecule

Interactions

50 interactions

InteractorPartnerSourcesPublicationsLink
CIB1_HUMANPSN2_HUMANBioGRID, HPRD, MINT10366599 details
CIB1_HUMANEXOSX_HUMANBioGRID, HPRD, IntAct15231747 details
CIB1_HUMANWASL_HUMANMINT16582881 details
CIB1_HUMANCDK4_HUMANBioGRID, IntAct21988832 details
CIB1_HUMANAURKB_HUMANBioGRID, IntAct21988832 details
CIB1_HUMANZDH17_HUMANBioGRID, IntAct24705354 details
CIB1_HUMANIF4G1_HUMANBioGRID, IntAct32296183 details
CIB1_HUMANTMM95_HUMANBioGRID, IntAct32296183 details
CIB1_HUMANCEAM6_HUMANBioGRID, IntAct32296183 details
CIB1_HUMANCALCB_HUMANBioGRID, IntAct32296183 details
CIB1_HUMANNCK2_HUMANBioGRID, IntAct32296183 details
CIB1_HUMANGLIS3_HUMANBioGRID, IntAct32296183 details
CIB1_HUMANCD27_HUMANBioGRID, IntAct32296183 details
CIB1_HUMANSFR19_HUMANBioGRID, IntAct32296183 details
CIB1_HUMANT10IP_HUMANBioGRID, IntAct32296183 details
CIB1_HUMANNDKM_HUMANBioGRID, IntAct32296183 details
CIB1_HUMANONEC3_HUMANBioGRID, IntAct32296183 details
CIB1_HUMANLSS_HUMANBioGRID, IntAct32296183 details
CIB1_HUMANPAX7_HUMANBioGRID, IntAct32296183 details
CIB1_HUMANSSX7_HUMANBioGRID, IntAct32296183 details
CIB1_HUMANZBT49_HUMANBioGRID, IntAct32296183 details
CIB1_HUMANELAP1_HUMANBioGRID, IntAct32296183 details
CIB1_HUMANFUCO_HUMANBioGRID, IntAct32296183 details
CIB1_HUMANM3K5_HUMANBioGRID, DIP19805025 details
CIB1_HUMANICAM1_HUMANIntAct32814053 details
CIB1_HUMAN1433G_HUMANIntAct32814053 details
CIB1_HUMANSETB1_HUMANIntAct32814053 details
CIB1_HUMANKAT5_HUMANIntAct32814053 details
CIB1_HUMANLMO3_HUMANIntAct32814053 details
CIB1_HUMANSPRE1_HUMANIntAct32814053 details
CIB1_HUMANPLK2_HUMANBioGRID, HPRD10523297 12651910 details
CIB1_HUMANPLK3_HUMANBioGRID, HPRD10523297 11039900 details
CIB1_HUMANRAC3_HUMANBioGRID, HPRD11756406 details
CIB1_HUMANUBR5_HUMANBioGRID, HPRD12011095 details
CIB1_HUMANNBR1_HUMANBioGRID11856312 details
CIB1_HUMANPSN1_HUMANBioGRID, HPRD10366599 details
CIB1_HUMANPRKDC_HUMANBioGRID, HPRD15190070 9372844 details
CIB1_HUMANNRIP1_HUMANBioGRID15604093 details
CIB1_HUMANTERT_HUMANBioGRID, HPRD15190070 20959453 details
CIB1_HUMANITA2B_HUMANBioGRID, HPRD24163826 9030514 details
CIB1_HUMANCASP2_HUMANBioGRID10745097 details
CIB1_HUMANFEZ1_HUMANHPRD11856312 details
CIB1_HUMANPAX3_HUMANHPRD11997098 details
CIB1_HUMANIFI6_HUMANHPRD15685448 details
CIB1_HUMANWASP_HUMANHPRD16582881 details
CIB1_HUMANITA2_HUMANMINT16582881 details
CIB1_HUMANPAK1_HUMANmbinfo16061695 details
CIB1_HUMANFAK1_HUMANBioGRID12881299 details
CIB1_HUMANITB3_HUMANBioGRID24163826 details
CIB1_HUMANITA5_HUMANBioGRID24163826 details