Entity Details

Primary name MCF2L_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionO15068
EntryNameMCF2L_HUMAN
FullNameGuanine nucleotide exchange factor DBS
TaxID9606
Evidenceevidence at protein level
Length1137
SequenceStatuscomplete
DateCreated1999-07-15
DateModified2021-06-02

Ontological Relatives

GenesMCF2L

GO terms

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GOName
GO:0005085 guanyl-nucleotide exchange factor activity
GO:0005615 extracellular space
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0005886 plasma membrane
GO:0007186 G protein-coupled receptor signaling pathway
GO:0012505 endomembrane system
GO:0031234 extrinsic component of cytoplasmic side of plasma membrane
GO:0035025 positive regulation of Rho protein signal transduction
GO:0035091 phosphatidylinositol binding
GO:0035556 intracellular signal transduction
GO:0043065 positive regulation of apoptotic process
GO:0051056 regulation of small GTPase mediated signal transduction

Subcellular Location

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Subcellular Location
Cell membrane
Cytoplasm
Endomembrane system

Domains

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DomainNameCategoryType
IPR000219 Dbl homology (DH) domainDomainDomain
IPR001251 CRAL-TRIO lipid binding domainDomainDomain
IPR001331 Guanine-nucleotide dissociation stimulator, CDC24, conserved siteSiteConserved site
IPR001452 SH3 domainDomainDomain
IPR001849 Pleckstrin homology domainDomainDomain
IPR002017 Spectrin repeatRepeatRepeat
IPR011993 PH-like domain superfamilyFamilyHomologous superfamily
IPR018159 Spectrin/alpha-actininRepeatRepeat
IPR035532 DBS, SH3 domainDomainDomain
IPR035534 DBS, PH domainDomainDomain
IPR035899 Dbl homology (DH) domain superfamilyFamilyHomologous superfamily
IPR036028 SH3-like domain superfamilyFamilyHomologous superfamily
IPR036865 CRAL-TRIO lipid binding domain superfamilyFamilyHomologous superfamily

Diseases

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