Entity Details

Primary name ARHGB_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionO15085
EntryNameARHGB_HUMAN
FullNameRho guanine nucleotide exchange factor 11
TaxID9606
Evidenceevidence at protein level
Length1522
SequenceStatuscomplete
DateCreated2003-08-29
DateModified2021-06-02

Ontological Relatives

GenesARHGEF11

GO terms

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GOName
GO:0001558 regulation of cell growth
GO:0001664 G protein-coupled receptor binding
GO:0005085 guanyl-nucleotide exchange factor activity
GO:0005096 GTPase activator activity
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0006941 striated muscle contraction
GO:0007186 G protein-coupled receptor signaling pathway
GO:0007266 Rho protein signal transduction
GO:0016020 membrane
GO:0030010 establishment of cell polarity
GO:0030036 actin cytoskeleton organization
GO:0043065 positive regulation of apoptotic process
GO:0043547 positive regulation of GTPase activity
GO:0045893 positive regulation of transcription, DNA-templated
GO:0051056 regulation of small GTPase mediated signal transduction

Subcellular Location

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Subcellular Location
Cytoplasm
Membrane

Domains

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DomainNameCategoryType
IPR000219 Dbl homology (DH) domainDomainDomain
IPR001478 PDZ domainDomainDomain
IPR001849 Pleckstrin homology domainDomainDomain
IPR011993 PH-like domain superfamilyFamilyHomologous superfamily
IPR015212 Regulator of G protein signalling-like domainDomainDomain
IPR016137 RGS domainDomainDomain
IPR032919 Rho guanine nucleotide exchange factor 11FamilyFamily
IPR035899 Dbl homology (DH) domain superfamilyFamilyHomologous superfamily
IPR036034 PDZ superfamilyFamilyHomologous superfamily
IPR036305 RGS domain superfamilyFamilyHomologous superfamily
IPR037803 Rho guanine nucleotide exchange factor 11, PH domainDomainDomain
IPR037889 Rho guanine nucleotide exchange factor 11, RGS domainDomainDomain
IPR041020 ARHGEF1-like, PH domainDomainDomain

Diseases

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Interactions

28 interactions

InteractorPartnerSourcesPublicationsLink
ARHGB_HUMANPLXB3_HUMANBioGRID, HPRD, IntAct12123608 12183458 12421765 details
ARHGB_HUMANABCA1_HUMANHPRD, IntAct16192269 16192272 details
ARHGB_HUMANABL1_HUMANIntAct17474147 details
ARHGB_HUMANCRK_HUMANIntAct17474147 details
ARHGB_HUMANFYN_HUMANIntAct17474147 details
ARHGB_HUMANGRB2_HUMANIntAct17474147 details
ARHGB_HUMANNCK1_HUMANIntAct17474147 details
ARHGB_HUMANP85A_HUMANIntAct17474147 details
ARHGB_HUMANPLCG1_HUMANIntAct17474147 details
ARHGB_HUMANRHOA_HUMANBioGRID, DIP, HPRD, IntAct, MINT10526156 15530360 20300064 21988832 28514442 32203420 details
ARHGB_HUMANCDC42_HUMANBioGRID, DIP, IntAct15530360 20936779 details
ARHGB_HUMANPLXB1_HUMANBioGRID, HPRD, Molecular Connections12123608 12183458 12220504 12730235 22404908 details
ARHGB_HUMANPLXB2_HUMANBioGRID, HPRD12123608 12183458 details
ARHGB_HUMANKS6A1_HUMANBioGRID30726710 details
ARHGB_HUMANPTPRF_HUMANBioGRID25458010 details
ARHGB_HUMANARHGB_HUMANHPRD12421765 details
ARHGB_HUMANMAP1B_HUMANHPRD16478718 details
ARHGB_HUMANMAP1A_HUMANHPRD16478718 details
ARHGB_HUMANDAAM1_HUMANIntAct22632972 details
ARHGB_HUMANDISC1_HUMANIntAct31413325 details
ARHGB_HUMANPKH4B_HUMANBioGRID, IntAct32203420 details
ARHGB_HUMANARH40_HUMANBioGRID, IntAct32203420 details
ARHGB_HUMANGNA13_HUMANBioGRID, HPRD10026210 12016230 32203420 details
ARHGB_HUMANGNA12_HUMANBioGRID, HPRD10026210 details
ARHGB_HUMANGNAQ_HUMANBioGRID12016230 details
ARHGB_HUMANEAA4_HUMANHPRD11242047 details
ARHGB_HUMANLPAR1_HUMANHPRD15755723 details
ARHGB_HUMANLPAR2_HUMANHPRD15755723 details