Entity Details

Primary name LX15B_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionO15296
EntryNameLX15B_HUMAN
FullNamePolyunsaturated fatty acid lipoxygenase ALOX15B
TaxID9606
Evidenceevidence at protein level
Length676
SequenceStatuscomplete
DateCreated2001-01-11
DateModified2021-06-02

Ontological Relatives

GenesALOX15B

GO terms

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GOName
GO:0005506 iron ion binding
GO:0005509 calcium ion binding
GO:0005634 nucleus
GO:0005829 cytosol
GO:0005856 cytoskeleton
GO:0005886 plasma membrane
GO:0005912 adherens junction
GO:0005925 focal adhesion
GO:0006629 lipid metabolic process
GO:0006644 phospholipid metabolic process
GO:0006915 apoptotic process
GO:0008285 negative regulation of cell population proliferation
GO:0008289 lipid binding
GO:0010744 positive regulation of macrophage derived foam cell differentiation
GO:0016020 membrane
GO:0016165 linoleate 13S-lipoxygenase activity
GO:0016702 oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen
GO:0019369 arachidonic acid metabolic process
GO:0019372 lipoxygenase pathway
GO:0019898 extrinsic component of membrane
GO:0030336 negative regulation of cell migration
GO:0030850 prostate gland development
GO:0030856 regulation of epithelial cell differentiation
GO:0032722 positive regulation of chemokine production
GO:0034440 lipid oxidation
GO:0035360 positive regulation of peroxisome proliferator activated receptor signaling pathway
GO:0036403 arachidonate 8(S)-lipoxygenase activity
GO:0043651 linoleic acid metabolic process
GO:0045618 positive regulation of keratinocyte differentiation
GO:0045786 negative regulation of cell cycle
GO:0045926 negative regulation of growth
GO:0050473 arachidonate 15-lipoxygenase activity
GO:0051122 hepoxilin biosynthetic process
GO:0070062 extracellular exosome
GO:0071926 endocannabinoid signaling pathway
GO:1901696 cannabinoid biosynthetic process
GO:1990136 linoleate 9S-lipoxygenase activity
GO:2001303 lipoxin A4 biosynthetic process

Subcellular Location

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Subcellular Location
Cell junction
Cell membrane
Cytoplasm
Membrane
Nucleus

Domains

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DomainNameCategoryType
IPR000907 LipoxygenaseFamilyFamily
IPR001024 PLAT/LH2 domainDomainDomain
IPR001885 Lipoxygenase, mammalianFamilyFamily
IPR013819 Lipoxygenase, C-terminalDomainDomain
IPR020833 Lipoxygenase, iron binding siteSiteBinding site
IPR020834 Lipoxygenase, conserved siteSiteConserved site
IPR036226 Lipoxigenase, C-terminal domain superfamilyFamilyHomologous superfamily
IPR036392 PLAT/LH2 domain superfamilyFamilyHomologous superfamily
IPR042062 Lipoxygenase, vertebrates, PLAT domainDomainDomain

Diseases

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