Entity Details

Primary name TLR3_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionO15455
EntryNameTLR3_HUMAN
FullNameToll-like receptor 3
TaxID9606
Evidenceevidence at protein level
Length904
SequenceStatuscomplete
DateCreated2002-01-31
DateModified2021-06-02

Ontological Relatives

GenesTLR3

GO terms

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GOName
GO:0000139 Golgi membrane
GO:0001774 microglial cell activation
GO:0002224 toll-like receptor signaling pathway
GO:0002730 regulation of dendritic cell cytokine production
GO:0002756 MyD88-independent toll-like receptor signaling pathway
GO:0003725 double-stranded RNA binding
GO:0004888 transmembrane signaling receptor activity
GO:0005615 extracellular space
GO:0005737 cytoplasm
GO:0005765 lysosomal membrane
GO:0005769 early endosome
GO:0005789 endoplasmic reticulum membrane
GO:0005887 integral component of plasma membrane
GO:0006954 inflammatory response
GO:0006972 hyperosmotic response
GO:0007165 signal transduction
GO:0007249 I-kappaB kinase/NF-kappaB signaling
GO:0007250 activation of NF-kappaB-inducing kinase activity
GO:0007252 I-kappaB phosphorylation
GO:0008584 male gonad development
GO:0009597 detection of virus
GO:0010008 endosome membrane
GO:0010628 positive regulation of gene expression
GO:0016020 membrane
GO:0031012 extracellular matrix
GO:0032722 positive regulation of chemokine production
GO:0032727 positive regulation of interferon-alpha production
GO:0032728 positive regulation of interferon-beta production
GO:0032729 positive regulation of interferon-gamma production
GO:0032735 positive regulation of interleukin-12 production
GO:0032755 positive regulation of interleukin-6 production
GO:0032757 positive regulation of interleukin-8 production
GO:0032760 positive regulation of tumor necrosis factor production
GO:0034123 positive regulation of toll-like receptor signaling pathway
GO:0034128 negative regulation of MyD88-independent toll-like receptor signaling pathway
GO:0034138 toll-like receptor 3 signaling pathway
GO:0034346 positive regulation of type III interferon production
GO:0035458 cellular response to interferon-beta
GO:0035666 TRIF-dependent toll-like receptor signaling pathway
GO:0035690 cellular response to drug
GO:0036020 endolysosome membrane
GO:0038023 signaling receptor activity
GO:0042742 defense response to bacterium
GO:0042802 identical protein binding
GO:0043065 positive regulation of apoptotic process
GO:0043123 positive regulation of I-kappaB kinase/NF-kappaB signaling
GO:0043330 response to exogenous dsRNA
GO:0043331 response to dsRNA
GO:0045087 innate immune response
GO:0045671 negative regulation of osteoclast differentiation
GO:0045766 positive regulation of angiogenesis
GO:0045944 positive regulation of transcription by RNA polymerase II
GO:0046330 positive regulation of JNK cascade
GO:0050729 positive regulation of inflammatory response
GO:0051092 positive regulation of NF-kappaB transcription factor activity
GO:0051607 defense response to virus
GO:0070266 necroptotic process
GO:0071260 cellular response to mechanical stimulus
GO:0071346 cellular response to interferon-gamma
GO:0071360 cellular response to exogenous dsRNA
GO:0097190 apoptotic signaling pathway
GO:0097191 extrinsic apoptotic signaling pathway
GO:0097527 necroptotic signaling pathway
GO:1901224 positive regulation of NIK/NF-kappaB signaling

Subcellular Location

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Subcellular Location
Early endosome
Endoplasmic reticulum membrane
Endosome membrane

Domains

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DomainNameCategoryType
IPR000157 Toll/interleukin-1 receptor homology (TIR) domainDomainDomain
IPR000483 Cysteine-rich flanking region, C-terminalDomainDomain
IPR001611 Leucine-rich repeatRepeatRepeat
IPR003591 Leucine-rich repeat, typical subtypeRepeatRepeat
IPR017241 Toll-like receptorFamilyFamily
IPR027173 Toll-like receptor 3FamilyFamily
IPR032675 Leucine-rich repeat domain superfamilyFamilyHomologous superfamily
IPR035897 Toll/interleukin-1 receptor homology (TIR) domain superfamilyFamilyHomologous superfamily
IPR041015 Toll-like receptor 3 trans-membrane domainDomainDomain

Diseases

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Interactions

42 interactions

InteractorPartnerSourcesPublicationsLink
TLR3_HUMANCHK2_HUMANBioGRID, MINT25640309 details
TLR3_HUMANTLR3_HUMANDIP, HPRD, IntAct, MINT15107846 18172197 23155421 25217833 details
TLR3_HUMANSIGL5_HUMANIntAct25187624 details
TLR3_HUMANSIGL6_HUMANIntAct25187624 details
TLR3_HUMANSIGL7_HUMANIntAct25187624 details
TLR3_HUMANSIGL9_HUMANIntAct25187624 details
TLR3_HUMANSIG10_HUMANIntAct25187624 details
TLR3_HUMANSIG11_HUMANIntAct25187624 details
TLR3_HUMANRN216_HUMANBioGRID, HPRD15107846 details
TLR3_HUMANMYD88_HUMANBioGRID, HPRD12646618 details
TLR3_HUMANMP2K6_HUMANBioGRID12609980 details
TLR3_HUMANTCAM1_HUMANBioGRID, HPRD12539043 14982987 25736436 27810922 31511519 details
TLR3_HUMANDRA_HUMANBioGRID24600555 details
TLR3_HUMANRN170_HUMANBioGRID31076723 details
TLR3_HUMANTCAM2_HUMANHPRD14519765 details
TLR3_HUMANP85A_HUMANBioGRID, MINT15502848 16858407 details
TLR3_HUMANSRC_HUMANMINT16858407 details
TLR3_HUMANTRIL_HUMANIntAct21911501 details
TLR3_HUMANMBL2_HUMANMINT24530528 details
TLR3_HUMANUN93B_HUMANBioGRID, UniProt22164301 31604943 details
TLR3_HUMANIRAK2_HUMANBioGRID17878161 details
TLR3_HUMANTRI69_HUMANBioGRID21911421 details
TLR3_HUMANTBK1_HUMANBioGRID21911421 27810922 details
TLR3_HUMANTRAF6_HUMANBioGRID, HPRD12609980 16115877 21911421 27810922 details
TLR3_HUMANM3K7_HUMANBioGRID12609980 16115877 details
TLR3_HUMANTAB2_HUMANBioGRID12609980 details
TLR3_HUMANRIPK1_HUMANBioGRID16115877 27810922 details
TLR3_HUMANKSYK_HUMANBioGRID23962979 details
TLR3_HUMANWDFY1_HUMANBioGRID25736436 details
TLR3_HUMANIRGM_HUMANBioGRID25891078 details
TLR3_HUMANRNF31_HUMANBioGRID27810922 details
TLR3_HUMANSHRPN_HUMANBioGRID27810922 details
TLR3_HUMANCASP8_HUMANBioGRID27810922 details
TLR3_HUMANFADD_HUMANBioGRID27810922 details
TLR3_HUMANHOIL1_HUMANBioGRID27810922 details
TLR3_HUMANNEMO_HUMANBioGRID27810922 details
TLR3_HUMANBIRC2_HUMANBioGRID27810922 details
TLR3_HUMANBIRC3_HUMANBioGRID27810922 details
TLR3_HUMANKCND2_HUMANBioGRID30758987 details
TLR3_HUMANKCND3_HUMANBioGRID30758987 details
TLR3_HUMANCD14_HUMANHPRD16473828 details
TLR3_HUMANCSK_HUMANHPRD16858407 details