Entity Details

Primary name PDPK1_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionO15530
EntryNamePDPK1_HUMAN
FullName3-phosphoinositide-dependent protein kinase 1
TaxID9606
Evidenceevidence at protein level
Length556
SequenceStatuscomplete
DateCreated2001-10-18
DateModified2021-06-02

Ontological Relatives

GenesPDPK1

GO terms

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GOName
GO:0002223 stimulatory C-type lectin receptor signaling pathway
GO:0003323 type B pancreatic cell development
GO:0004674 protein serine/threonine kinase activity
GO:0004676 3-phosphoinositide-dependent protein kinase activity
GO:0005158 insulin receptor binding
GO:0005524 ATP binding
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0005886 plasma membrane
GO:0005925 focal adhesion
GO:0006468 protein phosphorylation
GO:0006469 negative regulation of protein kinase activity
GO:0006972 hyperosmotic response
GO:0007173 epidermal growth factor receptor signaling pathway
GO:0010518 positive regulation of phospholipase activity
GO:0010667 negative regulation of cardiac muscle cell apoptotic process
GO:0014069 postsynaptic density
GO:0016004 phospholipase activator activity
GO:0016477 cell migration
GO:0018105 peptidyl-serine phosphorylation
GO:0018107 peptidyl-threonine phosphorylation
GO:0019722 calcium-mediated signaling
GO:0019901 protein kinase binding
GO:0030036 actin cytoskeleton organization
GO:0030168 platelet activation
GO:0030512 negative regulation of transforming growth factor beta receptor signaling pathway
GO:0031295 T cell costimulation
GO:0031410 cytoplasmic vesicle
GO:0032148 activation of protein kinase B activity
GO:0032869 cellular response to insulin stimulus
GO:0034122 negative regulation of toll-like receptor signaling pathway
GO:0035556 intracellular signal transduction
GO:0038095 Fc-epsilon receptor signaling pathway
GO:0042995 cell projection
GO:0043122 regulation of I-kappaB kinase/NF-kappaB signaling
GO:0043204 perikaryon
GO:0043274 phospholipase binding
GO:0043304 regulation of mast cell degranulation
GO:0043524 negative regulation of neuron apoptotic process
GO:0043536 positive regulation of blood vessel endothelial cell migration
GO:0045766 positive regulation of angiogenesis
GO:0046777 protein autophosphorylation
GO:0048041 focal adhesion assembly
GO:0050852 T cell receptor signaling pathway
GO:0051281 positive regulation of release of sequestered calcium ion into cytosol
GO:0051897 positive regulation of protein kinase B signaling
GO:0071364 cellular response to epidermal growth factor stimulus
GO:0097191 extrinsic apoptotic signaling pathway
GO:0106310 protein serine kinase activity
GO:0106311 protein threonine kinase activity
GO:1901796 regulation of signal transduction by p53 class mediator
GO:1903078 positive regulation of protein localization to plasma membrane
GO:1903672 positive regulation of sprouting angiogenesis
GO:1905564 positive regulation of vascular endothelial cell proliferation
GO:1990416 cellular response to brain-derived neurotrophic factor stimulus
GO:2000352 negative regulation of endothelial cell apoptotic process

Subcellular Location

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Subcellular Location
Cell junction
Cell membrane
Cytoplasm
Nucleus

Domains

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DomainNameCategoryType
IPR000719 Protein kinase domainDomainDomain
IPR008271 Serine/threonine-protein kinase, active siteSiteActive site
IPR011009 Protein kinase-like domain superfamilyFamilyHomologous superfamily
IPR011993 PH-like domain superfamilyFamilyHomologous superfamily
IPR017441 Protein kinase, ATP binding siteSiteBinding site
IPR033931 PDK1-type, PH domainDomainDomain
IPR039046 PDPK1 familyFamilyFamily

Diseases

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Drugs

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DrugNameSourceType
DB00482 CelecoxibDrugbanksmall molecule
DB01863 Inositol 1,3,4,5-TetrakisphosphateDrugbanksmall molecule
DB01933 7-HydroxystaurosporineDrugbanksmall molecule
DB01946 Bisindolylmaleimide VIIIDrugbanksmall molecule
DB02010 StaurosporineDrugbanksmall molecule
DB03777 Bisindolylmaleimide IDrugbanksmall molecule
DB04522 DexfosfoserineDrugbanksmall molecule
DB06932 10,11-dimethoxy-4-methyldibenzo[c,f]-2,7-naphthyridine-3,6-diamineDrugbanksmall molecule
DB07033 5-HYDROXY-3-[(1R)-1-(1H-PYRROL-2-YL)ETHYL]-2H-INDOL-2-ONEDrugbanksmall molecule
DB07132 1-{2-OXO-3-[(1R)-1-(1H-PYRROL-2-YL)ETHYL]-2H-INDOL-5-YL}UREADrugbanksmall molecule
DB07300 2-(1H-imidazol-1-yl)-9-methoxy-8-(2-methoxyethoxy)benzo[c][2,7]naphthyridin-4-amineDrugbanksmall molecule
DB07456 3-(1H-indol-3-yl)-4-(1-{2-[(2S)-1-methylpyrrolidinyl]ethyl}-1H-indol-3-yl)-1H-pyrrole-2,5-dioneDrugbanksmall molecule
DB07457 3-[1-(3-AMINOPROPYL)-1H-INDOL-3-YL]-4-(1H-INDOL-3-YL)-1H-PYRROLE-2,5-DIONEDrugbanksmall molecule
DB12010 FostamatinibDrugbanksmall molecule

Interactions

87 interactions

InteractorPartnerSourcesPublicationsLink
PDPK1_HUMANAKT1_HUMANBioGRID, DIP, HPRD, IntAct, MINT10226025 10698680 11278835 11313365 11438723 11445557 11825911 12149249 14500673 21775285 22569334 23397142 26256536 26264872 27563096 31467278 32876514 9368760 details
PDPK1_HUMAN1433T_HUMANBioGRID, HPRD, MINT12177059 19010391 details
PDPK1_HUMAN1433F_HUMANBioGRID, HPRD, IntAct, MINT12177059 31980649 details
PDPK1_HUMANPRS23_HUMANBioGRID, HPRD, IntAct16169070 details
PDPK1_HUMANCDAN1_HUMANHPRD, IntAct16169070 details
PDPK1_HUMANSGK1_HUMANBioGRID, HPRD, IntAct10191262 10357815 12387817 17314099 17916563 details
PDPK1_HUMANPTPRC_HUMANIntAct19167335 details
PDPK1_HUMANPTPRK_HUMANIntAct19167335 details
PDPK1_HUMANPTPRG_HUMANIntAct19167335 details
PDPK1_HUMANPTPRB_HUMANIntAct19167335 details
PDPK1_HUMANPTPRJ_HUMANIntAct19167335 details
PDPK1_HUMANPTPRO_HUMANIntAct19167335 details
PDPK1_HUMANPTN12_HUMANIntAct19167335 details
PDPK1_HUMANPTN22_HUMANIntAct19167335 details
PDPK1_HUMANPDPK1_HUMANBioGRID, HPRD, IntAct10455013 10856237 11481331 15144186 20562859 25384981 31980649 details
PDPK1_HUMANBLMH_HUMANBioGRID, MINT21900206 details
PDPK1_HUMANKTBL1_HUMANBioGRID, MINT21900206 details
PDPK1_HUMANPXL2B_HUMANBioGRID, MINT21900206 details
PDPK1_HUMANWDCP_HUMANBioGRID, MINT21900206 details
PDPK1_HUMANCAR11_HUMANBioGRID, HPRD, MINT15802604 21900206 details
PDPK1_HUMANDDIT4_HUMANBioGRID, MINT21900206 details
PDPK1_HUMANGIT1_HUMANBioGRID, MINT21900206 details
PDPK1_HUMANLC7L2_HUMANBioGRID, MINT21900206 details
PDPK1_HUMANPEA15_HUMANBioGRID, MINT21900206 details
PDPK1_HUMANPHAX_HUMANBioGRID, MINT21900206 details
PDPK1_HUMANPNO1_HUMANBioGRID, MINT21900206 details
PDPK1_HUMANPDIP2_HUMANBioGRID, MINT21900206 details
PDPK1_HUMANMTMR5_HUMANBioGRID, MINT21900206 details
PDPK1_HUMANSNF5_HUMANBioGRID, MINT21900206 details
PDPK1_HUMANSOCS3_HUMANBioGRID, MINT21900206 details
PDPK1_HUMANTELT_HUMANBioGRID, MINT21900206 details
PDPK1_HUMANXPO7_HUMANBioGRID, MINT21900206 details
PDPK1_HUMANXRCC6_HUMANBioGRID, MINT21900206 details
PDPK1_HUMANNIPA_HUMANBioGRID, MINT21900206 details
PDPK1_HUMANZN133_HUMANBioGRID, MINT21900206 details
PDPK1_HUMANSRPK1_HUMANBioGRID, IntAct23602568 details
PDPK1_HUMANZDH17_HUMANBioGRID, IntAct24705354 details
PDPK1_HUMANAPBB3_HUMANBioGRID, IntAct25814554 details
PDPK1_HUMANCSK_HUMANBioGRID, IntAct25814554 details
PDPK1_HUMANADA17_HUMANDIP16641105 details
PDPK1_HUMANKPCI_HUMANBioGRID, HPRD, IntAct10764742 31980649 details
PDPK1_HUMANJPH3_HUMANIntAct32814053 details
PDPK1_HUMANHD_HUMANIntAct32814053 details
PDPK1_HUMANATX3_HUMANIntAct32814053 details
PDPK1_HUMANKPCZ_HUMANBioGRID, HPRD10357815 10764742 11222751 11781095 14500673 9748166 details
PDPK1_HUMANKPCD_HUMANBioGRID, HPRD11381116 11781095 9748166 details
PDPK1_HUMANPKN2_HUMANBioGRID, HPRD10753910 10764742 11781095 details
PDPK1_HUMANKPCB_HUMANBioGRID, HPRD11376011 details
PDPK1_HUMANPKN1_HUMANBioGRID, HPRD10753910 10764742 10792047 details
PDPK1_HUMANKAPCA_HUMANBioGRID, HPRD10698939 details
PDPK1_HUMANMK08_HUMANBioGRID10357815 details
PDPK1_HUMANSTRAP_HUMANBioGRID, HPRD16251192 17916563 details
PDPK1_HUMANA4_HUMANBioGRID21832049 details
PDPK1_HUMANUBC9_HUMANBioGRID32876514 details
PDPK1_HUMANPK3C3_HUMANBioGRID32876514 details
PDPK1_HUMANMTOR_HUMANHPRD, MINT11438723 details
PDPK1_HUMANKS6B1_HUMANBioGRID, HPRD, MINT10601311 11438723 32876514 9271440 9427642 9445476 details
PDPK1_HUMANPININ_HUMANIntAct16169070 details
PDPK1_HUMAN2ABB_HUMANIntAct21075311 details
PDPK1_HUMANKS6A3_HUMANBioGRID, HPRD, IntAct10856237 25241761 details
PDPK1_HUMANCDC37_HUMANBioGRID, IntAct25036637 31980649 details
PDPK1_HUMANULK1_HUMANMINT26593251 details
PDPK1_HUMANDISC1_HUMANIntAct31413325 details
PDPK1_HUMANKPCE_HUMANHPRD, IntAct10945988 11062054 12640464 28934384 details
PDPK1_HUMANNHRF2_HUMANBioGRID, HPRD12387817 details
PDPK1_HUMANILK_HUMANBioGRID, HPRD11313365 details
PDPK1_HUMANKPCT_HUMANBioGRID15802604 details
PDPK1_HUMANM3K7_HUMANBioGRID26432169 details
PDPK1_HUMANAKT2_HUMANBioGRID, HPRD12048203 27563096 9374542 9512493 details
PDPK1_HUMANSENP3_HUMANBioGRID32876514 details
PDPK1_HUMANMLP3A_HUMANBioGRID32876514 details
PDPK1_HUMANWIPI2_HUMANBioGRID32876514 details
PDPK1_HUMANATG5_HUMANBioGRID32876514 details
PDPK1_HUMANITB3_HUMANHPRD10896934 details
PDPK1_HUMANSRC_HUMANHPRD11481331 details
PDPK1_HUMANGNDS_HUMANHPRD11889038 details
PDPK1_HUMANKS6A1_HUMANHPRD10480933 9430688 details
PDPK1_HUMANPAK1_HUMANHPRD10995762 details
PDPK1_HUMANSGK2_HUMANHPRD10548550 details
PDPK1_HUMANSGK3_HUMANHPRD10548550 details
PDPK1_HUMANAKT3_HUMANHPRD12162751 9512493 details
PDPK1_HUMANAKTIP_HUMANHPRD14749367 details
PDPK1_HUMANKS6B2_HUMANHPRD11733037 details
PDPK1_HUMANIRS1_HUMANHPRD15802620 details
PDPK1_HUMANPAXI_HUMANHPRD14585963 details
PDPK1_HUMANFAK2_HUMANHPRD14585963 details
PDPK1_HUMANHS90A_HUMANHPRD11779851 details