Entity Details

Primary name IRAK2_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionO43187
EntryNameIRAK2_HUMAN
FullNameInterleukin-1 receptor-associated kinase-like 2
TaxID9606
Evidenceevidence at protein level
Length625
SequenceStatuscomplete
DateCreated2001-01-11
DateModified2021-06-02

Ontological Relatives

GenesIRAK2

GO terms

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GOName
GO:0000187 obsolete activation of MAPK activity
GO:0001959 regulation of cytokine-mediated signaling pathway
GO:0002224 toll-like receptor signaling pathway
GO:0002755 MyD88-dependent toll-like receptor signaling pathway
GO:0004672 protein kinase activity
GO:0004674 protein serine/threonine kinase activity
GO:0005524 ATP binding
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0005886 plasma membrane
GO:0006468 protein phosphorylation
GO:0006954 inflammatory response
GO:0007249 I-kappaB kinase/NF-kappaB signaling
GO:0007254 JNK cascade
GO:0010008 endosome membrane
GO:0019221 cytokine-mediated signaling pathway
GO:0031663 lipopolysaccharide-mediated signaling pathway
GO:0032088 negative regulation of NF-kappaB transcription factor activity
GO:0034162 toll-like receptor 9 signaling pathway
GO:0035556 intracellular signal transduction
GO:0042803 protein homodimerization activity
GO:0046982 protein heterodimerization activity
GO:0051092 positive regulation of NF-kappaB transcription factor activity
GO:0070423 nucleotide-binding oligomerization domain containing signaling pathway
GO:0070498 interleukin-1-mediated signaling pathway
GO:0070555 response to interleukin-1

Subcellular Location

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Domains

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DomainNameCategoryType
IPR000488 Death domainDomainDomain
IPR000719 Protein kinase domainDomainDomain
IPR011009 Protein kinase-like domain superfamilyFamilyHomologous superfamily
IPR011029 Death-like domain superfamilyFamilyHomologous superfamily
IPR033611 Interleukin-1 receptor-associated kinase-like 2FamilyFamily
IPR042151 IRAK2, death domainDomainDomain

Diseases

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Interactions

31 interactions

InteractorPartnerSourcesPublicationsLink
IRAK2_HUMANTRAF6_HUMANBioGRID, HPRD, IntAct, MINT10383454 17878161 21903422 21988832 26250868 28514442 9374458 details
IRAK2_HUMANIRAK1_HUMANBioGRID, HPRD, IntAct, MINT10383454 12138165 21903422 details
IRAK2_HUMANARAF_HUMANBioGRID, IntAct21903422 details
IRAK2_HUMANTADBP_HUMANBioGRID, IntAct21903422 details
IRAK2_HUMANSTT3A_HUMANBioGRID, IntAct21903422 details
IRAK2_HUMANZC12A_HUMANBioGRID, IntAct21903422 details
IRAK2_HUMANTOLIP_HUMANBioGRID, IntAct21903422 details
IRAK2_HUMANSARM1_HUMANBioGRID21903422 details
IRAK2_HUMANMYD88_HUMANBioGRID, DIP, HPRD, MINT10383454 12659850 20485341 22011580 9374458 details
IRAK2_HUMANIRAK2_HUMANHPRD, MINT10383454 details
IRAK2_HUMANIRAK3_HUMANBioGRID, HPRD, IntAct, MINT10383454 21903422 details
IRAK2_HUMANTIRAP_HUMANBioGRID, HPRD, IntAct11544529 21903422 details
IRAK2_HUMANIRAK4_HUMANBioGRID, DIP, IntAct20485341 21903422 details
IRAK2_HUMANRBBP4_HUMANIntAct21903422 details
IRAK2_HUMANCCD47_HUMANIntAct21903422 details
IRAK2_HUMANYTHD2_HUMANIntAct21903422 details
IRAK2_HUMANHS90B_HUMANIntAct22939624 details
IRAK2_HUMANIL1R1_HUMANBioGRID, HPRD12659850 9374458 details
IRAK2_HUMANTLR3_HUMANBioGRID17878161 details
IRAK2_HUMANPELI1_HUMANBioGRID, HPRD17675297 details
IRAK2_HUMANPELI2_HUMANBioGRID, HPRD17675297 details
IRAK2_HUMANPELI3_HUMANBioGRID, HPRD17675297 details
IRAK2_HUMANTNAP3_HUMANBioGRID21220427 details
IRAK2_HUMANPSN1_HUMANBioGRID18996842 details
IRAK2_HUMANTNFL9_HUMANBioGRID24084649 details
IRAK2_HUMANRN152_HUMANBioGRID31930677 details
IRAK2_HUMANRASH_HUMANHPRD11744690 details
IRAK2_HUMANTCAM2_HUMANHPRD12721283 details
IRAK2_HUMANSMAD2_HUMANHPRD15761153 details
IRAK2_HUMANSMUF1_HUMANHPRD15761153 details
IRAK2_HUMANTLR4_HUMANHPRD9625770 details