Entity Details

Primary name RNC_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionQ9NRR4
EntryNameRNC_HUMAN
FullNameRibonuclease 3
TaxID9606
Evidenceevidence at protein level
Length1374
SequenceStatuscomplete
DateCreated2002-01-23
DateModified2021-06-02

Ontological Relatives

GenesDROSHA

GO terms

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GOName
GO:0001530 lipopolysaccharide binding
GO:0003723 RNA binding
GO:0003725 double-stranded RNA binding
GO:0004525 ribonuclease III activity
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005730 nucleolus
GO:0005829 cytosol
GO:0006396 RNA processing
GO:0010586 miRNA metabolic process
GO:0010628 positive regulation of gene expression
GO:0014069 postsynaptic density
GO:0016075 rRNA catabolic process
GO:0017151 DEAD/H-box RNA helicase binding
GO:0030422 production of siRNA involved in RNA interference
GO:0031053 primary miRNA processing
GO:0031054 pre-miRNA processing
GO:0042254 ribosome biogenesis
GO:0042803 protein homodimerization activity
GO:0045589 regulation of regulatory T cell differentiation
GO:0046332 SMAD binding
GO:0046872 metal ion binding
GO:0050727 regulation of inflammatory response
GO:0050829 defense response to Gram-negative bacterium
GO:0050830 defense response to Gram-positive bacterium
GO:0070412 R-SMAD binding
GO:0070877 microprocessor complex
GO:0070878 primary miRNA binding
GO:2000628 regulation of miRNA metabolic process

Subcellular Location

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Subcellular Location
Nucleus

Domains

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DomainNameCategoryType
IPR000999 Ribonuclease III domainDomainDomain
IPR011907 Ribonuclease IIIFamilyFamily
IPR014720 Double-stranded RNA-binding domainDomainDomain
IPR036389 Ribonuclease III, endonuclease domain superfamilyFamilyHomologous superfamily
IPR044442 RNase III, double-stranded RNA binding domain, animalDomainDomain

Diseases

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