Entity Details

Primary name SIR3_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionQ9NTG7
EntryNameSIR3_HUMAN
FullNameNAD-dependent protein deacetylase sirtuin-3, mitochondrial
TaxID9606
Evidenceevidence at protein level
Length399
SequenceStatuscomplete
DateCreated2003-10-31
DateModified2021-06-02

Ontological Relatives

GenesSIRT3

GO terms

Show/Hide Table
GOName
GO:0003950 NAD+ ADP-ribosyltransferase activity
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005739 mitochondrion
GO:0005759 mitochondrial matrix
GO:0006471 protein ADP-ribosylation
GO:0006476 protein deacetylation
GO:0007005 mitochondrion organization
GO:0007568 aging
GO:0008270 zinc ion binding
GO:0009060 aerobic respiration
GO:0017136 NAD-dependent histone deacetylase activity
GO:0019899 enzyme binding
GO:0032024 positive regulation of insulin secretion
GO:0032991 protein-containing complex
GO:0034979 NAD-dependent protein deacetylase activity
GO:0034983 peptidyl-lysine deacetylation
GO:0043565 sequence-specific DNA binding
GO:0070373 negative regulation of ERK1 and ERK2 cascade
GO:0070403 NAD+ binding
GO:1901671 positive regulation of superoxide dismutase activity
GO:1902553 positive regulation of catalase activity
GO:2000304 positive regulation of ceramide biosynthetic process
GO:2000378 negative regulation of reactive oxygen species metabolic process

Subcellular Location

Show/Hide Table
Subcellular Location
Mitochondrion matrix

Domains

Show/Hide Table
DomainNameCategoryType
IPR003000 Sirtuin familyFamilyFamily
IPR026590 Sirtuin family, catalytic core domainDomainDomain
IPR026591 Sirtuin, catalytic core small domain superfamilyFamilyHomologous superfamily
IPR029035 DHS-like NAD/FAD-binding domain superfamilyFamilyHomologous superfamily

Diseases

Show/Hide Table

Drugs

Show/Hide Table
DrugNameSourceType
DB02059 Adenosine-5-DiphosphoriboseDrugbanksmall molecule