Entity Details

Primary name HXA2_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionO43364
EntryNameHXA2_HUMAN
FullNameHomeobox protein Hox-A2
TaxID9606
Evidenceevidence at transcript level
Length376
SequenceStatuscomplete
DateCreated1999-07-15
DateModified2021-06-02

Ontological Relatives

GenesHOXA2

GO terms

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GOName
GO:0000785 chromatin
GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding
GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific
GO:0001227 DNA-binding transcription repressor activity, RNA polymerase II-specific
GO:0001709 cell fate determination
GO:0002076 osteoblast development
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0006357 regulation of transcription by RNA polymerase II
GO:0007379 segment specification
GO:0008045 motor neuron axon guidance
GO:0009952 anterior/posterior pattern specification
GO:0009953 dorsal/ventral pattern formation
GO:0021568 rhombomere 2 development
GO:0021658 rhombomere 3 morphogenesis
GO:0035284 brain segmentation
GO:0042474 middle ear morphogenesis
GO:0043231 intracellular membrane-bounded organelle
GO:0045665 negative regulation of neuron differentiation
GO:0045668 negative regulation of osteoblast differentiation
GO:0045944 positive regulation of transcription by RNA polymerase II
GO:0048703 embryonic viscerocranium morphogenesis
GO:0071300 cellular response to retinoic acid
GO:1990837 sequence-specific double-stranded DNA binding

Subcellular Location

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Subcellular Location
Nucleus

Domains

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DomainNameCategoryType
IPR001356 Homeobox domainDomainDomain
IPR001827 Homeobox protein, antennapedia type, conserved siteSiteConserved site
IPR009057 Homeobox-like domain superfamilyFamilyHomologous superfamily
IPR017970 Homeobox, conserved siteSiteConserved site
IPR020479 Homeobox domain, metazoaDomainDomain

Diseases

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