Entity Details

Primary name ADA22_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionQ9P0K1
EntryNameADA22_HUMAN
FullNameDisintegrin and metalloproteinase domain-containing protein 22
TaxID9606
Evidenceevidence at protein level
Length906
SequenceStatuscomplete
DateCreated2001-06-20
DateModified2021-06-02

Ontological Relatives

GenesADAM22

GO terms

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GOName
GO:0004222 metalloendopeptidase activity
GO:0005178 integrin binding
GO:0005886 plasma membrane
GO:0007155 cell adhesion
GO:0007162 negative regulation of cell adhesion
GO:0007417 central nervous system development
GO:0008344 adult locomotory behavior
GO:0016021 integral component of membrane
GO:0022011 myelination in peripheral nervous system
GO:0030424 axon
GO:0098978 glutamatergic synapse
GO:0099061 integral component of postsynaptic density membrane
GO:0099645 neurotransmitter receptor localization to postsynaptic specialization membrane

Subcellular Location

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Subcellular Location
Cell membrane
Cell projection

Domains

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DomainNameCategoryType
IPR000742 EGF-like domainDomainDomain
IPR001590 Peptidase M12B, ADAM/reprolysinDomainDomain
IPR001762 Disintegrin domainDomainDomain
IPR002870 Peptidase M12B, propeptideDomainDomain
IPR006586 ADAM, cysteine-rich domainDomainDomain
IPR013111 EGF-like domain, extracellularDomainDomain
IPR018358 Disintegrin, conserved siteSiteConserved site
IPR024079 Metallopeptidase, catalytic domain superfamilyFamilyHomologous superfamily
IPR034027 Reprolysin domain, adamalysin-typeDomainDomain
IPR036436 Disintegrin domain superfamilyFamilyHomologous superfamily

Diseases

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