Entity Details

Primary name TNIK_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionQ9UKE5
EntryNameTNIK_HUMAN
FullNameTRAF2 and NCK-interacting protein kinase
TaxID9606
Evidenceevidence at protein level
Length1360
SequenceStatuscomplete
DateCreated2003-02-28
DateModified2021-06-02

Ontological Relatives

GenesTNIK

GO terms

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GOName
GO:0000165 MAPK cascade
GO:0001934 positive regulation of protein phosphorylation
GO:0004672 protein kinase activity
GO:0004674 protein serine/threonine kinase activity
GO:0005524 ATP binding
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0005856 cytoskeleton
GO:0006468 protein phosphorylation
GO:0007010 cytoskeleton organization
GO:0007256 obsolete activation of JNKK activity
GO:0016055 Wnt signaling pathway
GO:0016324 apical plasma membrane
GO:0030033 microvillus assembly
GO:0031098 stress-activated protein kinase signaling cascade
GO:0031532 actin cytoskeleton reorganization
GO:0032147 activation of protein kinase activity
GO:0035556 intracellular signal transduction
GO:0046777 protein autophosphorylation
GO:0048812 neuron projection morphogenesis
GO:0048814 regulation of dendrite morphogenesis
GO:0055037 recycling endosome
GO:0070062 extracellular exosome
GO:0072659 protein localization to plasma membrane
GO:0098793 presynapse
GO:0098978 glutamatergic synapse
GO:0099092 postsynaptic density, intracellular component
GO:0106310 protein serine kinase activity
GO:0106311 protein threonine kinase activity

Subcellular Location

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Subcellular Location
Cytoplasm
Nucleus
Recycling endosome

Domains

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DomainNameCategoryType
IPR000719 Protein kinase domainDomainDomain
IPR001180 Citron homology (CNH) domainDomainDomain
IPR008271 Serine/threonine-protein kinase, active siteSiteActive site
IPR011009 Protein kinase-like domain superfamilyFamilyHomologous superfamily
IPR017441 Protein kinase, ATP binding siteSiteBinding site

Diseases

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Drugs

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DrugNameSourceType
DB12010 FostamatinibDrugbanksmall molecule

Interactions

185 interactions

InteractorPartnerSourcesPublicationsLink
TNIK_HUMANAKAP9_HUMANBioGRID, IntAct17043677 31413325 details
TNIK_HUMANANK2_HUMANBioGRID, IntAct17043677 31413325 details
TNIK_HUMANCLUS_HUMANBioGRID, IntAct17043677 31413325 details
TNIK_HUMANCNKR2_HUMANBioGRID, IntAct17043677 31413325 details
TNIK_HUMANDYST_HUMANBioGRID, IntAct17043677 31413325 details
TNIK_HUMANHARS1_HUMANBioGRID, IntAct17043677 31413325 details
TNIK_HUMANKIBRA_HUMANBioGRID, IntAct17043677 31413325 details
TNIK_HUMANMYT1L_HUMANIntAct17043677 31413325 details
TNIK_HUMANNCOR2_HUMANBioGRID, IntAct17043677 31413325 details
TNIK_HUMANNFM_HUMANBioGRID, IntAct17043677 31413325 details
TNIK_HUMANMYOME_HUMANBioGRID, IntAct17043677 31413325 details
TNIK_HUMANASPP1_HUMANBioGRID, IntAct17043677 31413325 details
TNIK_HUMANSPTB2_HUMANBioGRID, IntAct17043677 31413325 details
TNIK_HUMANSRGP3_HUMANBioGRID, IntAct17043677 31413325 details
TNIK_HUMANDISC1_HUMANBioGRID, IntAct, MINT17043677 29961565 31413325 details
TNIK_HUMANTRIM2_HUMANBioGRID, IntAct17043677 31413325 details
TNIK_HUMANNCK1_HUMANHPRD, IntAct10521462 17474147 details
TNIK_HUMANTF7L2_HUMANMINT19816403 details
TNIK_HUMANCTNB1_HUMANMINT19816403 details
TNIK_HUMANTRAF6_HUMANBioGRID, DIP22904686 details
TNIK_HUMANTRAF2_HUMANBioGRID, DIP, HPRD10521462 22904686 details
TNIK_HUMANDPYL3_HUMANBioGRID, IntAct17043677 31413325 details
TNIK_HUMANDYHC1_HUMANBioGRID, IntAct17043677 31413325 details
TNIK_HUMANDPYL2_HUMANBioGRID, IntAct17043677 31413325 details
TNIK_HUMANPPM1E_HUMANBioGRID, IntAct17043677 31413325 details
TNIK_HUMANGSE1_HUMANBioGRID, IntAct17043677 31413325 details
TNIK_HUMANCBPC1_HUMANBioGRID, IntAct17043677 31413325 details
TNIK_HUMANSYNE1_HUMANBioGRID, IntAct17043677 31413325 details
TNIK_HUMANMACF1_HUMANBioGRID, IntAct17043677 31413325 details
TNIK_HUMANTIAM2_HUMANBioGRID, IntAct17043677 31413325 details
TNIK_HUMANGOGA4_HUMANBioGRID, IntAct17043677 31413325 details
TNIK_HUMANLIS1_HUMANBioGRID, IntAct17043677 31413325 details
TNIK_HUMANSNX6_HUMANBioGRID, IntAct17043677 31413325 details
TNIK_HUMANSMCE1_HUMANBioGRID, IntAct17043677 31413325 details
TNIK_HUMANACTG_HUMANBioGRID, IntAct17043677 31413325 details
TNIK_HUMANNEDD4_HUMANBioGRID20159449 28405688 details
TNIK_HUMANTNKS1_HUMANBioGRID17043677 details
TNIK_HUMANSOS1_HUMANBioGRID17043677 details
TNIK_HUMANTBB2A_HUMANBioGRID17043677 details
TNIK_HUMANSMUF1_HUMANBioGRID20804422 details
TNIK_HUMANRAP2A_HUMANHPRD15342639 details
TNIK_HUMANRANG_HUMANIntAct17353931 details
TNIK_HUMANBUB3_HUMANIntAct17353931 details
TNIK_HUMANFKBP3_HUMANIntAct17353931 details
TNIK_HUMANTHIC_HUMANIntAct17353931 details
TNIK_HUMANPSA2_HUMANIntAct17353931 details
TNIK_HUMANSTRAP_HUMANIntAct17353931 details
TNIK_HUMANAATM_HUMANIntAct17353931 details
TNIK_HUMANROA3_HUMANIntAct17353931 details
TNIK_HUMANML12A_HUMANIntAct17353931 details
TNIK_HUMANSF3B6_HUMANIntAct17353931 details
TNIK_HUMANDHSO_HUMANIntAct17353931 details
TNIK_HUMANRS14_HUMANIntAct17353931 details
TNIK_HUMANDHCR7_HUMANIntAct17353931 details
TNIK_HUMANPSMD6_HUMANIntAct17353931 details
TNIK_HUMANAATC_HUMANIntAct17353931 details
TNIK_HUMANPIMT_HUMANIntAct17353931 details
TNIK_HUMANEMC1_HUMANIntAct17353931 details
TNIK_HUMANPDCD5_HUMANIntAct17353931 details
TNIK_HUMANANM1_HUMANIntAct17353931 details
TNIK_HUMAN2AAA_HUMANIntAct17353931 details
TNIK_HUMANRCC2_HUMANIntAct17353931 details
TNIK_HUMANPPAC_HUMANIntAct17353931 details
TNIK_HUMANPSD13_HUMANIntAct17353931 details
TNIK_HUMANPCBP3_HUMANIntAct17353931 details
TNIK_HUMANRIR1_HUMANIntAct17353931 details
TNIK_HUMANTFAM_HUMANIntAct17353931 details
TNIK_HUMANPSA1_HUMANIntAct17353931 details
TNIK_HUMANNAA15_HUMANIntAct17353931 details
TNIK_HUMANCNPY2_HUMANIntAct17353931 details
TNIK_HUMANECHM_HUMANIntAct17353931 details
TNIK_HUMANANXA2_HUMANIntAct17353931 details
TNIK_HUMANCOPB2_HUMANIntAct17353931 details
TNIK_HUMANCBR1_HUMANIntAct17353931 details
TNIK_HUMANDEST_HUMANIntAct17353931 details
TNIK_HUMANRM14_HUMANIntAct17353931 details
TNIK_HUMANTR112_HUMANIntAct17353931 details
TNIK_HUMANKCY_HUMANIntAct17353931 details
TNIK_HUMANIMDH2_HUMANIntAct17353931 details
TNIK_HUMANUCHL1_HUMANIntAct17353931 details
TNIK_HUMANCALM2_HUMANIntAct17353931 details
TNIK_HUMANSODM_HUMANIntAct17353931 details
TNIK_HUMANFSCN1_HUMANIntAct17353931 details
TNIK_HUMANARP2_HUMANIntAct17353931 details
TNIK_HUMANRT16_HUMANIntAct17353931 details
TNIK_HUMANOTUB1_HUMANIntAct17353931 details
TNIK_HUMANSET_HUMANIntAct17353931 details
TNIK_HUMANMK01_HUMANIntAct17353931 details
TNIK_HUMANGLRX3_HUMANIntAct17353931 details
TNIK_HUMANSERC_HUMANIntAct17353931 details
TNIK_HUMANPSMD1_HUMANIntAct17353931 details
TNIK_HUMANPCBP1_HUMANIntAct17353931 details
TNIK_HUMANTEAD3_HUMANIntAct17353931 details
TNIK_HUMANRU2B_HUMANIntAct17353931 details
TNIK_HUMANEIF3M_HUMANIntAct17353931 details
TNIK_HUMANEIF3H_HUMANIntAct17353931 details
TNIK_HUMANPPIH_HUMANIntAct17353931 details
TNIK_HUMANLYAR_HUMANIntAct17353931 details
TNIK_HUMANNUDC_HUMANIntAct17353931 details
TNIK_HUMANRUVB2_HUMANIntAct17353931 details
TNIK_HUMANLRC59_HUMANIntAct17353931 details
TNIK_HUMANRPN2_HUMANIntAct17353931 details
TNIK_HUMANCYC_HUMANIntAct17353931 details
TNIK_HUMANSIAS_HUMANIntAct17353931 details
TNIK_HUMANCYBP_HUMANIntAct17353931 details
TNIK_HUMANTHIL_HUMANIntAct17353931 details
TNIK_HUMANC1TC_HUMANIntAct17353931 details
TNIK_HUMANSYSC_HUMANIntAct17353931 details
TNIK_HUMANPRS4_HUMANIntAct17353931 details
TNIK_HUMANBAP31_HUMANIntAct17353931 details
TNIK_HUMANKPRA_HUMANIntAct17353931 details
TNIK_HUMANSEPT4_HUMANIntAct17353931 details
TNIK_HUMANSTK26_HUMANDIP22797597 details
TNIK_HUMANM3K7_HUMANBioGRID, DIP22904686 details
TNIK_HUMANTAB2_HUMANBioGRID, DIP22904686 details
TNIK_HUMANIKKB_HUMANBioGRID, DIP22904686 details
TNIK_HUMANFRY_HUMANIntAct31413325 details
TNIK_HUMANCACO2_HUMANIntAct31413325 details
TNIK_HUMANBORC5_HUMANIntAct31413325 details
TNIK_HUMANDDX5_HUMANIntAct31413325 details
TNIK_HUMANDCTN1_HUMANIntAct31413325 details
TNIK_HUMANDTNA_HUMANIntAct31413325 details
TNIK_HUMANZC3H1_HUMANIntAct31413325 details
TNIK_HUMANCPEB3_HUMANIntAct31413325 details
TNIK_HUMANNINL_HUMANIntAct31413325 details
TNIK_HUMANLRCH1_HUMANIntAct31413325 details
TNIK_HUMANSYNE2_HUMANIntAct31413325 details
TNIK_HUMANPLCL2_HUMANIntAct31413325 details
TNIK_HUMANSMHD1_HUMANIntAct31413325 details
TNIK_HUMANUBP24_HUMANIntAct31413325 details
TNIK_HUMANSIR1_HUMANIntAct31413325 details
TNIK_HUMANGLCE_HUMANIntAct31413325 details
TNIK_HUMANTANC2_HUMANIntAct31413325 details
TNIK_HUMANANR17_HUMANIntAct31413325 details
TNIK_HUMANBEX3_HUMANIntAct31413325 details
TNIK_HUMANGATM_HUMANIntAct31413325 details
TNIK_HUMANPCLO_HUMANIntAct31413325 details
TNIK_HUMANANK3_HUMANIntAct31413325 details
TNIK_HUMANHNRPF_HUMANIntAct31413325 details
TNIK_HUMANLUZP2_HUMANIntAct31413325 details
TNIK_HUMANTBB2B_HUMANIntAct31413325 details
TNIK_HUMANSOGA3_HUMANIntAct31413325 details
TNIK_HUMANKIF5C_HUMANIntAct31413325 details
TNIK_HUMANNFL_HUMANIntAct31413325 details
TNIK_HUMANNDUS1_HUMANIntAct31413325 details
TNIK_HUMANNUP98_HUMANIntAct31413325 details
TNIK_HUMANTHAP4_HUMANIntAct31413325 details
TNIK_HUMANCRBN_HUMANIntAct31413325 details
TNIK_HUMANUBR5_HUMANIntAct31413325 details
TNIK_HUMANSNX7_HUMANIntAct31413325 details
TNIK_HUMANATRX_HUMANIntAct31413325 details
TNIK_HUMANKANL2_HUMANIntAct31413325 details
TNIK_HUMANKIF1A_HUMANIntAct31413325 details
TNIK_HUMANUACA_HUMANIntAct31413325 details
TNIK_HUMANSTRAB_HUMANIntAct31413325 details
TNIK_HUMANYETS2_HUMANIntAct31413325 details
TNIK_HUMANWWC3_HUMANIntAct31413325 details
TNIK_HUMANCENPJ_HUMANIntAct31413325 details
TNIK_HUMANPRS7_HUMANIntAct31413325 details
TNIK_HUMANZN248_HUMANIntAct31413325 details
TNIK_HUMANAN36B_HUMANIntAct31413325 details
TNIK_HUMANSHOT1_HUMANIntAct31413325 details
TNIK_HUMANPTN11_HUMANIntAct31413325 details
TNIK_HUMANTRI27_HUMANIntAct31413325 details
TNIK_HUMANNDF6_HUMANIntAct31413325 details
TNIK_HUMANSNPC4_HUMANIntAct31413325 details
TNIK_HUMANSON_HUMANIntAct31413325 details
TNIK_HUMANSTAT2_HUMANIntAct31413325 details
TNIK_HUMANSPT5H_HUMANIntAct31413325 details
TNIK_HUMANBRCC3_HUMANIntAct31413325 details
TNIK_HUMANASPC1_HUMANIntAct31413325 details
TNIK_HUMANSMC6_HUMANIntAct31413325 details
TNIK_HUMANWDR26_HUMANIntAct31413325 details
TNIK_HUMANEDEM3_HUMANIntAct31413325 details
TNIK_HUMANUBP32_HUMANIntAct31413325 details
TNIK_HUMANDHX16_HUMANIntAct31413325 details
TNIK_HUMANNCOA1_HUMANIntAct31413325 details
TNIK_HUMANBECN1_HUMANIntAct31413325 details
TNIK_HUMANDZIP3_HUMANIntAct31413325 details
TNIK_HUMANNCOR1_HUMANIntAct31413325 details
TNIK_HUMANKDM4A_HUMANIntAct31413325 details
TNIK_HUMANTATD2_HUMANIntAct31413325 details
TNIK_HUMANCE350_HUMANIntAct31413325 details
TNIK_HUMANTNIK_HUMANHPRD17192257 details
TNIK_HUMANGELS_HUMANHPRD10521462 details