Entity Details

Primary name TNIK_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionQ9UKE5
EntryNameTNIK_HUMAN
FullNameTRAF2 and NCK-interacting protein kinase
TaxID9606
Evidenceevidence at protein level
Length1360
SequenceStatuscomplete
DateCreated2003-02-28
DateModified2021-06-02

Ontological Relatives

GenesTNIK

GO terms

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GOName
GO:0000165 MAPK cascade
GO:0001934 positive regulation of protein phosphorylation
GO:0004672 protein kinase activity
GO:0004674 protein serine/threonine kinase activity
GO:0005524 ATP binding
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0005856 cytoskeleton
GO:0006468 protein phosphorylation
GO:0007010 cytoskeleton organization
GO:0007256 obsolete activation of JNKK activity
GO:0016055 Wnt signaling pathway
GO:0016324 apical plasma membrane
GO:0030033 microvillus assembly
GO:0031098 stress-activated protein kinase signaling cascade
GO:0031532 actin cytoskeleton reorganization
GO:0032147 activation of protein kinase activity
GO:0035556 intracellular signal transduction
GO:0046777 protein autophosphorylation
GO:0048812 neuron projection morphogenesis
GO:0048814 regulation of dendrite morphogenesis
GO:0055037 recycling endosome
GO:0070062 extracellular exosome
GO:0072659 protein localization to plasma membrane
GO:0098793 presynapse
GO:0098978 glutamatergic synapse
GO:0099092 postsynaptic density, intracellular component
GO:0106310 protein serine kinase activity
GO:0106311 protein threonine kinase activity

Subcellular Location

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Subcellular Location
Cytoplasm
Nucleus
Recycling endosome

Domains

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DomainNameCategoryType
IPR000719 Protein kinase domainDomainDomain
IPR001180 Citron homology (CNH) domainDomainDomain
IPR008271 Serine/threonine-protein kinase, active siteSiteActive site
IPR011009 Protein kinase-like domain superfamilyFamilyHomologous superfamily
IPR017441 Protein kinase, ATP binding siteSiteBinding site

Diseases

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Disease IDSourceNameDescription
617028 OMIMMental retardation, autosomal recessive 54 (MRT54)A form of mental retardation, a disorder characterized by significantly below average general intellectual functioning associated with impairments in adaptive behavior and manifested during the developmental period. MRT54 patients manifest intellectual disability, delayed speech and hyperactivity. The disease may be caused by variants affecting the gene represented in this entry.

Drugs

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DrugNameSourceType
DB12010 FostamatinibDrugbanksmall molecule

Interactions

185 interactions

InteractorPartnerSourcesPublicationsLink
TNIK_HUMANAKAP9_HUMANBioGRID, IntAct17043677 31413325 details
TNIK_HUMANANK2_HUMANBioGRID, IntAct17043677 31413325 details
TNIK_HUMANCLUS_HUMANBioGRID, IntAct17043677 31413325 details
TNIK_HUMANCNKR2_HUMANBioGRID, IntAct17043677 31413325 details
TNIK_HUMANDYST_HUMANBioGRID, IntAct17043677 31413325 details
TNIK_HUMANHARS1_HUMANBioGRID, IntAct17043677 31413325 details
TNIK_HUMANKIBRA_HUMANBioGRID, IntAct17043677 31413325 details
TNIK_HUMANMYT1L_HUMANIntAct17043677 31413325 details
TNIK_HUMANNCOR2_HUMANBioGRID, IntAct17043677 31413325 details
TNIK_HUMANNFM_HUMANBioGRID, IntAct17043677 31413325 details
TNIK_HUMANMYOME_HUMANBioGRID, IntAct17043677 31413325 details
TNIK_HUMANASPP1_HUMANBioGRID, IntAct17043677 31413325 details
TNIK_HUMANSPTB2_HUMANBioGRID, IntAct17043677 31413325 details
TNIK_HUMANSRGP3_HUMANBioGRID, IntAct17043677 31413325 details
TNIK_HUMANDISC1_HUMANBioGRID, IntAct, MINT17043677 29961565 31413325 details
TNIK_HUMANTRIM2_HUMANBioGRID, IntAct17043677 31413325 details
TNIK_HUMANNCK1_HUMANHPRD, IntAct10521462 17474147 details
TNIK_HUMANTF7L2_HUMANMINT19816403 details
TNIK_HUMANCTNB1_HUMANMINT19816403 details
TNIK_HUMANTRAF6_HUMANBioGRID, DIP22904686 details
TNIK_HUMANTRAF2_HUMANBioGRID, DIP, HPRD10521462 22904686 details
TNIK_HUMANDPYL3_HUMANBioGRID, IntAct17043677 31413325 details
TNIK_HUMANDYHC1_HUMANBioGRID, IntAct17043677 31413325 details
TNIK_HUMANDPYL2_HUMANBioGRID, IntAct17043677 31413325 details
TNIK_HUMANPPM1E_HUMANBioGRID, IntAct17043677 31413325 details
TNIK_HUMANGSE1_HUMANBioGRID, IntAct17043677 31413325 details
TNIK_HUMANCBPC1_HUMANBioGRID, IntAct17043677 31413325 details
TNIK_HUMANSYNE1_HUMANBioGRID, IntAct17043677 31413325 details
TNIK_HUMANMACF1_HUMANBioGRID, IntAct17043677 31413325 details
TNIK_HUMANTIAM2_HUMANBioGRID, IntAct17043677 31413325 details
TNIK_HUMANGOGA4_HUMANBioGRID, IntAct17043677 31413325 details
TNIK_HUMANLIS1_HUMANBioGRID, IntAct17043677 31413325 details
TNIK_HUMANSNX6_HUMANBioGRID, IntAct17043677 31413325 details
TNIK_HUMANSMCE1_HUMANBioGRID, IntAct17043677 31413325 details
TNIK_HUMANACTG_HUMANBioGRID, IntAct17043677 31413325 details
TNIK_HUMANNEDD4_HUMANBioGRID20159449 28405688 details
TNIK_HUMANTNKS1_HUMANBioGRID17043677 details
TNIK_HUMANSOS1_HUMANBioGRID17043677 details
TNIK_HUMANTBB2A_HUMANBioGRID17043677 details
TNIK_HUMANSMUF1_HUMANBioGRID20804422 details
TNIK_HUMANRAP2A_HUMANHPRD15342639 details
TNIK_HUMANRANG_HUMANIntAct17353931 details
TNIK_HUMANBUB3_HUMANIntAct17353931 details
TNIK_HUMANFKBP3_HUMANIntAct17353931 details
TNIK_HUMANTHIC_HUMANIntAct17353931 details
TNIK_HUMANPSA2_HUMANIntAct17353931 details
TNIK_HUMANSTRAP_HUMANIntAct17353931 details
TNIK_HUMANAATM_HUMANIntAct17353931 details
TNIK_HUMANROA3_HUMANIntAct17353931 details
TNIK_HUMANML12A_HUMANIntAct17353931 details
TNIK_HUMANSF3B6_HUMANIntAct17353931 details
TNIK_HUMANDHSO_HUMANIntAct17353931 details
TNIK_HUMANRS14_HUMANIntAct17353931 details
TNIK_HUMANDHCR7_HUMANIntAct17353931 details
TNIK_HUMANPSMD6_HUMANIntAct17353931 details
TNIK_HUMANAATC_HUMANIntAct17353931 details
TNIK_HUMANPIMT_HUMANIntAct17353931 details
TNIK_HUMANEMC1_HUMANIntAct17353931 details
TNIK_HUMANPDCD5_HUMANIntAct17353931 details
TNIK_HUMANANM1_HUMANIntAct17353931 details
TNIK_HUMAN2AAA_HUMANIntAct17353931 details
TNIK_HUMANRCC2_HUMANIntAct17353931 details
TNIK_HUMANPPAC_HUMANIntAct17353931 details
TNIK_HUMANPSD13_HUMANIntAct17353931 details
TNIK_HUMANPCBP3_HUMANIntAct17353931 details
TNIK_HUMANRIR1_HUMANIntAct17353931 details
TNIK_HUMANTFAM_HUMANIntAct17353931 details
TNIK_HUMANPSA1_HUMANIntAct17353931 details
TNIK_HUMANNAA15_HUMANIntAct17353931 details
TNIK_HUMANCNPY2_HUMANIntAct17353931 details
TNIK_HUMANECHM_HUMANIntAct17353931 details
TNIK_HUMANANXA2_HUMANIntAct17353931 details
TNIK_HUMANCOPB2_HUMANIntAct17353931 details
TNIK_HUMANCBR1_HUMANIntAct17353931 details
TNIK_HUMANDEST_HUMANIntAct17353931 details
TNIK_HUMANRM14_HUMANIntAct17353931 details
TNIK_HUMANTR112_HUMANIntAct17353931 details
TNIK_HUMANKCY_HUMANIntAct17353931 details
TNIK_HUMANIMDH2_HUMANIntAct17353931 details
TNIK_HUMANUCHL1_HUMANIntAct17353931 details
TNIK_HUMANCALM2_HUMANIntAct17353931 details
TNIK_HUMANSODM_HUMANIntAct17353931 details
TNIK_HUMANFSCN1_HUMANIntAct17353931 details
TNIK_HUMANARP2_HUMANIntAct17353931 details
TNIK_HUMANRT16_HUMANIntAct17353931 details
TNIK_HUMANOTUB1_HUMANIntAct17353931 details
TNIK_HUMANSET_HUMANIntAct17353931 details
TNIK_HUMANMK01_HUMANIntAct17353931 details
TNIK_HUMANGLRX3_HUMANIntAct17353931 details
TNIK_HUMANSERC_HUMANIntAct17353931 details
TNIK_HUMANPSMD1_HUMANIntAct17353931 details
TNIK_HUMANPCBP1_HUMANIntAct17353931 details
TNIK_HUMANTEAD3_HUMANIntAct17353931 details
TNIK_HUMANRU2B_HUMANIntAct17353931 details
TNIK_HUMANEIF3M_HUMANIntAct17353931 details
TNIK_HUMANEIF3H_HUMANIntAct17353931 details
TNIK_HUMANPPIH_HUMANIntAct17353931 details
TNIK_HUMANLYAR_HUMANIntAct17353931 details
TNIK_HUMANNUDC_HUMANIntAct17353931 details
TNIK_HUMANRUVB2_HUMANIntAct17353931 details
TNIK_HUMANLRC59_HUMANIntAct17353931 details
TNIK_HUMANRPN2_HUMANIntAct17353931 details
TNIK_HUMANCYC_HUMANIntAct17353931 details
TNIK_HUMANSIAS_HUMANIntAct17353931 details
TNIK_HUMANCYBP_HUMANIntAct17353931 details
TNIK_HUMANTHIL_HUMANIntAct17353931 details
TNIK_HUMANC1TC_HUMANIntAct17353931 details
TNIK_HUMANSYSC_HUMANIntAct17353931 details
TNIK_HUMANPRS4_HUMANIntAct17353931 details
TNIK_HUMANBAP31_HUMANIntAct17353931 details
TNIK_HUMANKPRA_HUMANIntAct17353931 details
TNIK_HUMANSEPT4_HUMANIntAct17353931 details
TNIK_HUMANSTK26_HUMANDIP22797597 details
TNIK_HUMANM3K7_HUMANBioGRID, DIP22904686 details
TNIK_HUMANTAB2_HUMANBioGRID, DIP22904686 details
TNIK_HUMANIKKB_HUMANBioGRID, DIP22904686 details
TNIK_HUMANFRY_HUMANIntAct31413325 details
TNIK_HUMANCACO2_HUMANIntAct31413325 details
TNIK_HUMANBORC5_HUMANIntAct31413325 details
TNIK_HUMANDDX5_HUMANIntAct31413325 details
TNIK_HUMANDCTN1_HUMANIntAct31413325 details
TNIK_HUMANDTNA_HUMANIntAct31413325 details
TNIK_HUMANZC3H1_HUMANIntAct31413325 details
TNIK_HUMANCPEB3_HUMANIntAct31413325 details
TNIK_HUMANNINL_HUMANIntAct31413325 details
TNIK_HUMANLRCH1_HUMANIntAct31413325 details
TNIK_HUMANSYNE2_HUMANIntAct31413325 details
TNIK_HUMANPLCL2_HUMANIntAct31413325 details
TNIK_HUMANSMHD1_HUMANIntAct31413325 details
TNIK_HUMANUBP24_HUMANIntAct31413325 details
TNIK_HUMANSIR1_HUMANIntAct31413325 details
TNIK_HUMANGLCE_HUMANIntAct31413325 details
TNIK_HUMANTANC2_HUMANIntAct31413325 details
TNIK_HUMANANR17_HUMANIntAct31413325 details
TNIK_HUMANBEX3_HUMANIntAct31413325 details
TNIK_HUMANGATM_HUMANIntAct31413325 details
TNIK_HUMANPCLO_HUMANIntAct31413325 details
TNIK_HUMANANK3_HUMANIntAct31413325 details
TNIK_HUMANHNRPF_HUMANIntAct31413325 details
TNIK_HUMANLUZP2_HUMANIntAct31413325 details
TNIK_HUMANTBB2B_HUMANIntAct31413325 details
TNIK_HUMANSOGA3_HUMANIntAct31413325 details
TNIK_HUMANKIF5C_HUMANIntAct31413325 details
TNIK_HUMANNFL_HUMANIntAct31413325 details
TNIK_HUMANNDUS1_HUMANIntAct31413325 details
TNIK_HUMANNUP98_HUMANIntAct31413325 details
TNIK_HUMANTHAP4_HUMANIntAct31413325 details
TNIK_HUMANCRBN_HUMANIntAct31413325 details
TNIK_HUMANUBR5_HUMANIntAct31413325 details
TNIK_HUMANSNX7_HUMANIntAct31413325 details
TNIK_HUMANATRX_HUMANIntAct31413325 details
TNIK_HUMANKANL2_HUMANIntAct31413325 details
TNIK_HUMANKIF1A_HUMANIntAct31413325 details
TNIK_HUMANUACA_HUMANIntAct31413325 details
TNIK_HUMANSTRAB_HUMANIntAct31413325 details
TNIK_HUMANYETS2_HUMANIntAct31413325 details
TNIK_HUMANWWC3_HUMANIntAct31413325 details
TNIK_HUMANCENPJ_HUMANIntAct31413325 details
TNIK_HUMANPRS7_HUMANIntAct31413325 details
TNIK_HUMANZN248_HUMANIntAct31413325 details
TNIK_HUMANAN36B_HUMANIntAct31413325 details
TNIK_HUMANSHOT1_HUMANIntAct31413325 details
TNIK_HUMANPTN11_HUMANIntAct31413325 details
TNIK_HUMANTRI27_HUMANIntAct31413325 details
TNIK_HUMANNDF6_HUMANIntAct31413325 details
TNIK_HUMANSNPC4_HUMANIntAct31413325 details
TNIK_HUMANSON_HUMANIntAct31413325 details
TNIK_HUMANSTAT2_HUMANIntAct31413325 details
TNIK_HUMANSPT5H_HUMANIntAct31413325 details
TNIK_HUMANBRCC3_HUMANIntAct31413325 details
TNIK_HUMANASPC1_HUMANIntAct31413325 details
TNIK_HUMANSMC6_HUMANIntAct31413325 details
TNIK_HUMANWDR26_HUMANIntAct31413325 details
TNIK_HUMANEDEM3_HUMANIntAct31413325 details
TNIK_HUMANUBP32_HUMANIntAct31413325 details
TNIK_HUMANDHX16_HUMANIntAct31413325 details
TNIK_HUMANNCOA1_HUMANIntAct31413325 details
TNIK_HUMANBECN1_HUMANIntAct31413325 details
TNIK_HUMANDZIP3_HUMANIntAct31413325 details
TNIK_HUMANNCOR1_HUMANIntAct31413325 details
TNIK_HUMANKDM4A_HUMANIntAct31413325 details
TNIK_HUMANTATD2_HUMANIntAct31413325 details
TNIK_HUMANCE350_HUMANIntAct31413325 details
TNIK_HUMANTNIK_HUMANHPRD17192257 details
TNIK_HUMANGELS_HUMANHPRD10521462 details