Entity Details

Primary name SMC3_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionQ9UQE7
EntryNameSMC3_HUMAN
FullNameStructural maintenance of chromosomes protein 3
TaxID9606
Evidenceevidence at protein level
Length1217
SequenceStatuscomplete
DateCreated2003-03-25
DateModified2021-06-02

Ontological Relatives

GenesSMC3

GO terms

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GOName
GO:0000278 mitotic cell cycle
GO:0000775 chromosome, centromeric region
GO:0000785 chromatin
GO:0000800 lateral element
GO:0003682 chromatin binding
GO:0003777 microtubule motor activity
GO:0005524 ATP binding
GO:0005654 nucleoplasm
GO:0005694 chromosome
GO:0005829 cytosol
GO:0006275 regulation of DNA replication
GO:0006281 DNA repair
GO:0007062 sister chromatid cohesion
GO:0008278 cohesin complex
GO:0016363 nuclear matrix
GO:0016887 ATP hydrolysis activity
GO:0019827 stem cell population maintenance
GO:0030893 meiotic cohesin complex
GO:0034991 nuclear meiotic cohesin complex
GO:0036033 mediator complex binding
GO:0046982 protein heterodimerization activity
GO:0048487 beta-tubulin binding
GO:0051301 cell division
GO:0051321 meiotic cell cycle
GO:0070840 dynein complex binding
GO:0090307 mitotic spindle assembly
GO:0097431 mitotic spindle pole

Subcellular Location

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Subcellular Location
Chromosome
Nucleus

Domains

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DomainNameCategoryType
IPR003395 RecF/RecN/SMC, N-terminalDomainDomain
IPR010935 SMCs flexible hingeDomainDomain
IPR024704 Structural maintenance of chromosomes proteinFamilyFamily
IPR027417 P-loop containing nucleoside triphosphate hydrolaseFamilyHomologous superfamily
IPR036277 SMCs flexible hinge superfamilyFamilyHomologous superfamily
IPR041741 Structural maintenance of chromosomes 3, ABC domain, eukaryoticDomainDomain

Diseases

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Interactions

87 interactions

InteractorPartnerSourcesPublicationsLink
SMC3_HUMANCEP63_HUMANBioGRID, IntAct17043677 31413325 details
SMC3_HUMANSTAG1_HUMANBioGRID, DIP, IntAct, MINT, UniProt10931856 11076961 15855230 17112726 17113138 17349791 17962804 22885700 26344197 26496610 29867216 31010829 details
SMC3_HUMANRAD21_HUMANBioGRID, DIP, IntAct, MINT, UniProt10931856 15737063 15855230 16802858 17112726 17113138 17349791 18235444 20818333 21043528 21111234 21880767 22145905 22885700 22939629 24981860 26344197 26496610 28514442 31010829 details
SMC3_HUMANCDCA5_HUMANBioGRID, IntAct, UniProt15837422 17349791 21111234 26186194 26496610 28514442 31010829 details
SMC3_HUMANAPC_HUMANBioGRID, IntAct20936779 details
SMC3_HUMANMTR1B_HUMANBioGRID, IntAct26514267 details
SMC3_HUMANDISC1_HUMANBioGRID, IntAct17043677 31413325 details
SMC3_HUMANMIPT3_HUMANBioGRID, IntAct17043677 31413325 details
SMC3_HUMANMXI1_HUMANBioGRID, HPRD9528857 details
SMC3_HUMANMAD3_HUMANBioGRID9528857 details
SMC3_HUMANMAD4_HUMANBioGRID9528857 details
SMC3_HUMANMAD1_HUMANBioGRID, HPRD9528857 details
SMC3_HUMANKIFA3_HUMANBioGRID, HPRD9506951 details
SMC3_HUMANFEZ1_HUMANBioGRID, HPRD16484223 details
SMC3_HUMANFEZ2_HUMANBioGRID16484223 details
SMC3_HUMANRPGR_HUMANBioGRID, HPRD16043481 details
SMC3_HUMANESR1_HUMANBioGRID20348541 details
SMC3_HUMANESCO2_HUMANBioGRID30779731 details
SMC3_HUMANSUMO2_HUMANBioGRID32786267 details
SMC3_HUMANCRCM_HUMANIntAct17353931 details
SMC3_HUMANMYC_HUMANBioGRID, IntAct17353931 29467282 details
SMC3_HUMANWRP73_HUMANIntAct17353931 details
SMC3_HUMANHLAB_HUMANIntAct17353931 details
SMC3_HUMANWAPL_HUMANBioGRID, IntAct, UniProt17112726 17113138 17349791 20360068 21111234 26496610 31010829 details
SMC3_HUMANSTAG2_HUMANBioGRID, DIP, IntAct, MINT, UniProt10931856 15737063 15855230 17113138 17349791 17962804 18235444 19629043 22885700 24981860 26344197 26496610 29263825 29867216 31010829 details
SMC3_HUMANPDS5B_HUMANBioGRID, IntAct, MINT, UniProt15855230 17113138 17349791 22293751 26344197 26496610 31010829 details
SMC3_HUMANSMC1A_HUMANBioGRID, DIP, HPRD, IntAct, UniProt10931856 11076961 11590136 11877376 12759374 17112726 17113138 17349791 18832153 21111234 21880767 22885700 22939629 23242214 24981860 26344197 26496610 27173435 30021884 31010829 9789013 unassigned1312 details
SMC3_HUMANPDS5A_HUMANBioGRID, IntAct, UniProt15855230 17113138 17349791 19906707 21111234 26344197 31010829 details
SMC3_HUMANMDM2_HUMANIntAct20195357 details
SMC3_HUMANMCMBP_HUMANMINT22540012 24299456 details
SMC3_HUMANNDC80_HUMANMINT23361318 details
SMC3_HUMANATRX_HUMANUniProt20159591 details
SMC3_HUMANUBP15_HUMANBioGRID, IntAct27173435 unassigned1312 details
SMC3_HUMANTF3C4_HUMANBioGRID, IntAct27173435 unassigned1312 details
SMC3_HUMANEP15R_HUMANBioGRID, IntAct27173435 unassigned1312 details
SMC3_HUMANMCM6_HUMANBioGRID, IntAct27173435 unassigned1312 details
SMC3_HUMANMCM2_HUMANBioGRID, IntAct27173435 unassigned1312 details
SMC3_HUMANMCM4_HUMANBioGRID, IntAct27173435 unassigned1312 details
SMC3_HUMANJIP4_HUMANBioGRID, IntAct27173435 unassigned1312 details
SMC3_HUMANNS1BP_HUMANBioGRID, IntAct27173435 unassigned1312 details
SMC3_HUMANREC8_HUMANBioGRID, MINT12759374 24981860 details
SMC3_HUMANSYCP3_HUMANBioGRID12759374 details
SMC3_HUMANSMCA5_HUMANBioGRID12198550 details
SMC3_HUMANHDAC2_HUMANBioGRID12198550 details
SMC3_HUMANNUMA1_HUMANBioGRID11590136 details
SMC3_HUMANTBB5_HUMANBioGRID11590136 details
SMC3_HUMANSTAG3_HUMANBioGRID11483963 31010829 details
SMC3_HUMANATM_HUMANBioGRID17478428 details
SMC3_HUMANPMS1_HUMANBioGRID17148452 details
SMC3_HUMANAIRE_HUMANBioGRID20085707 27365398 details
SMC3_HUMANWFDC5_HUMANBioGRID19906707 details
SMC3_HUMANSRRM1_HUMANBioGRID16159877 details
SMC3_HUMANPAXI1_HUMANBioGRID17925232 details
SMC3_HUMANTERF2_HUMANBioGRID20811636 details
SMC3_HUMANHDAC5_HUMANBioGRID21081666 details
SMC3_HUMANSMRCD_HUMANBioGRID21549307 details
SMC3_HUMANRPB1_HUMANBioGRID21880767 details
SMC3_HUMANCTCF_HUMANBioGRID21880767 details
SMC3_HUMANSPT5H_HUMANBioGRID21880767 details
SMC3_HUMANNIPBL_HUMANBioGRID20720539 31010829 details
SMC3_HUMANCDK8_HUMANBioGRID20720539 details
SMC3_HUMANMECP2_HUMANBioGRID22615490 details
SMC3_HUMANNSE2_HUMANBioGRID22751501 details
SMC3_HUMANFBX6_HUMANBioGRID22268729 details
SMC3_HUMANEFMT3_HUMANBioGRID23349634 details
SMC3_HUMANSIR6_HUMANBioGRID24169447 details
SMC3_HUMANSF3B3_HUMANBioGRID26344197 31010829 details
SMC3_HUMANSMC1B_HUMANBioGRID, HPRD11564881 12759374 15125634 26344197 details
SMC3_HUMANRN126_HUMANBioGRID26508657 details
SMC3_HUMANU5S1_HUMANBioGRID28515276 31010829 details
SMC3_HUMANTRI29_HUMANBioGRID26095369 details
SMC3_HUMANH2AX_HUMANBioGRID26095369 details
SMC3_HUMANDCA15_HUMANBioGRID31452512 details
SMC3_HUMANANR55_HUMANBioGRID31620119 details
SMC3_HUMANDSRAD_HUMANBioGRID31010829 details
SMC3_HUMANRBM10_HUMANBioGRID31010829 details
SMC3_HUMANU520_HUMANBioGRID31010829 details
SMC3_HUMANTR150_HUMANBioGRID31010829 details
SMC3_HUMANRRP5_HUMANBioGRID31010829 details
SMC3_HUMANPRP31_HUMANBioGRID31010829 details
SMC3_HUMANHSP7C_HUMANBioGRID31010829 details
SMC3_HUMANHNRPU_HUMANBioGRID31010829 details
SMC3_HUMANRBM15_HUMANBioGRID31010829 details
SMC3_HUMANPRP6_HUMANBioGRID31010829 details
SMC3_HUMANSF3B1_HUMANBioGRID31010829 details
SMC3_HUMANHNRH1_HUMANBioGRID31010829 details
SMC3_HUMANDDX47_HUMANBioGRID31010829 details