Entity Details

Primary name M3K2_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionQ9Y2U5
EntryNameM3K2_HUMAN
FullNameMitogen-activated protein kinase kinase kinase 2
TaxID9606
Evidenceevidence at protein level
Length619
SequenceStatuscomplete
DateCreated2000-05-30
DateModified2021-06-02

Ontological Relatives

GenesMAP3K2

GO terms

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GOName
GO:0000187 obsolete activation of MAPK activity
GO:0004672 protein kinase activity
GO:0004674 protein serine/threonine kinase activity
GO:0004709 MAP kinase kinase kinase activity
GO:0005524 ATP binding
GO:0005654 nucleoplasm
GO:0005829 cytosol
GO:0006468 protein phosphorylation
GO:0007257 obsolete activation of JUN kinase activity
GO:0019901 protein kinase binding
GO:0045893 positive regulation of transcription, DNA-templated
GO:0046872 metal ion binding
GO:0071260 cellular response to mechanical stimulus
GO:0106310 protein serine kinase activity
GO:0106311 protein threonine kinase activity

Subcellular Location

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Subcellular Location
Cytoplasm
Nucleus

Domains

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DomainNameCategoryType
IPR000270 PB1 domainDomainDomain
IPR000719 Protein kinase domainDomainDomain
IPR011009 Protein kinase-like domain superfamilyFamilyHomologous superfamily
IPR017441 Protein kinase, ATP binding siteSiteBinding site
IPR034879 Mitogen-activated protein kinase kinase kinase 2/3, PB1 domainDomainDomain

Diseases

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Drugs

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DrugNameSourceType
DB06616 BosutinibDrugbanksmall molecule
DB12010 FostamatinibDrugbanksmall molecule

Interactions

41 interactions

InteractorPartnerSourcesPublicationsLink
M3K2_HUMAN1433E_HUMANBioGRID, HPRD, IntAct, MINT17979178 26496610 9452471 details
M3K2_HUMANM3K3_HUMANBioGRID, IntAct14743216 24975362 26496610 details
M3K2_HUMANCHIP_HUMANBioGRID, MINT20588253 details
M3K2_HUMANMP2K5_HUMANBioGRID, IntAct11073940 19903815 21988832 24975362 28514442 31980649 details
M3K2_HUMANXIAP_HUMANBioGRID, MINT18761086 24975362 details
M3K2_HUMANSMYD3_HUMANDIP27066749 details
M3K2_HUMANSH22A_HUMANBioGRID, HPRD11073940 12640115 details
M3K2_HUMANMP2K7_HUMANBioGRID, HPRD10713157 24975362 9372971 details
M3K2_HUMANMP2K4_HUMANBioGRID, HPRD10713157 17906693 7997270 9162092 details
M3K2_HUMANNEMO_HUMANBioGRID20098747 details
M3K2_HUMANPIBF1_HUMANBioGRID20936779 details
M3K2_HUMANNEDD4_HUMANBioGRID19953087 details
M3K2_HUMANNED4L_HUMANBioGRID19953087 details
M3K2_HUMANSMUF1_HUMANBioGRID, HPRD15820682 19318350 20804422 details
M3K2_HUMANM3K2_HUMANBioGRID15001576 17906693 24975362 9162092 details
M3K2_HUMANMP2K3_HUMANBioGRID9162092 details
M3K2_HUMANBIRC2_HUMANBioGRID24975362 details
M3K2_HUMANSTABP_HUMANBioGRID24975362 details
M3K2_HUMANUBP2_HUMANBioGRID24975362 details
M3K2_HUMANCTNB1_HUMANBioGRID26884171 details
M3K2_HUMANGLI1_HUMANBioGRID29662197 details
M3K2_HUMANPKN2_HUMANHPRD10818102 12640115 details
M3K2_HUMAN1433B_HUMANBioGRID, IntAct, MINT15324660 17353931 24255178 26496610 28514442 details
M3K2_HUMAN1433S_HUMANBioGRID, IntAct, MINT15778465 26496610 details
M3K2_HUMANUBC_HUMANMINT20588253 details
M3K2_HUMANHS90B_HUMANIntAct22939624 details
M3K2_HUMAN1433Z_HUMANBioGRID, HPRD, IntAct26496610 28514442 9452471 details
M3K2_HUMANRAB3I_HUMANBioGRID, IntAct27173435 unassigned1312 details
M3K2_HUMANCBY1_HUMANBioGRID, IntAct27173435 unassigned1312 details
M3K2_HUMANMK08_HUMANBioGRID, HPRD10713157 details
M3K2_HUMANSTK38_HUMANBioGRID17906693 29969578 details
M3K2_HUMANHS90A_HUMANBioGRID22939624 details
M3K2_HUMANMK07_HUMANBioGRID24975362 details
M3K2_HUMANGSK3B_HUMANBioGRID26884171 details
M3K2_HUMANFBW1A_HUMANBioGRID26884171 details
M3K2_HUMANAXIN1_HUMANBioGRID26884171 details
M3K2_HUMANAXIN2_HUMANBioGRID26884171 details
M3K2_HUMANST38L_HUMANBioGRID30504095 details
M3K2_HUMANM3K5_HUMANHPRD12912994 details
M3K2_HUMANIKBA_HUMANHPRD10085062 details
M3K2_HUMANWNK1_HUMANHPRD14681216 details