Entity Details

Primary name PARP3_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionQ9Y6F1
EntryNamePARP3_HUMAN
FullNameProtein mono-ADP-ribosyltransferase PARP3
TaxID9606
Evidenceevidence at protein level
Length533
SequenceStatuscomplete
DateCreated2001-09-26
DateModified2021-06-02

Ontological Relatives

GenesPARP3

GO terms

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GOName
GO:0000723 telomere maintenance
GO:0003824 catalytic activity
GO:0003950 NAD+ ADP-ribosyltransferase activity
GO:0005654 nucleoplasm
GO:0005730 nucleolus
GO:0005737 cytoplasm
GO:0005814 centriole
GO:0006281 DNA repair
GO:0006302 double-strand break repair
GO:0006471 protein ADP-ribosylation
GO:0016604 nuclear body
GO:0030592 DNA ADP-ribosylation
GO:0035861 site of double-strand break
GO:0045171 intercellular bridge
GO:0045829 negative regulation of isotype switching
GO:0051106 positive regulation of DNA ligation
GO:0060236 regulation of mitotic spindle organization
GO:0070212 protein poly-ADP-ribosylation
GO:0070213 protein auto-ADP-ribosylation
GO:0140289 protein mono-ADP-ribosylation
GO:0140294 NAD DNA ADP-ribosyltransferase activity
GO:1905662 negative regulation of telomerase RNA reverse transcriptase activity
GO:1990166 protein localization to site of double-strand break
GO:1990404 protein ADP-ribosylase activity
GO:2001034 positive regulation of double-strand break repair via nonhomologous end joining

Subcellular Location

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Subcellular Location
Chromosome
Cytoplasm
Nucleus

Domains

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DomainNameCategoryType
IPR004102 Poly(ADP-ribose) polymerase, regulatory domainDomainDomain
IPR008893 WGR domainDomainDomain
IPR012317 Poly(ADP-ribose) polymerase, catalytic domainDomainDomain
IPR031275 Protein mono-ADP-ribosyltransferase PARP3FamilyFamily
IPR036616 Poly(ADP-ribose) polymerase, regulatory domain superfamilyFamilyHomologous superfamily
IPR036930 WGR domain superfamilyFamilyHomologous superfamily

Diseases

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Drugs

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DrugNameSourceType
DB07677 2-methyl-3,5,7,8-tetrahydro-4H-thiopyrano[4,3-d]pyrimidin-4-oneDrugbanksmall molecule
DB08058 4-[3-(1,4-diazepan-1-ylcarbonyl)-4-fluorobenzyl]phthalazin-1(2H)-oneDrugbanksmall molecule
DB08348 N~2~,N~2~-DIMETHYL-N~1~-(6-OXO-5,6-DIHYDROPHENANTHRIDIN-2-YL)GLYCINAMIDEDrugbanksmall molecule
DB09074 OlaparibDrugbanksmall molecule
DB12332 RucaparibDrugbanksmall molecule