Entity Details

Primary name ROBO1_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionQ9Y6N7
EntryNameROBO1_HUMAN
FullNameRoundabout homolog 1
TaxID9606
Evidenceevidence at protein level
Length1651
SequenceStatuscomplete
DateCreated2004-06-21
DateModified2021-06-02

Ontological Relatives

GenesROBO1

GO terms

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GOName
GO:0002042 cell migration involved in sprouting angiogenesis
GO:0003148 outflow tract septum morphogenesis
GO:0003180 aortic valve morphogenesis
GO:0003184 pulmonary valve morphogenesis
GO:0003272 endocardial cushion formation
GO:0005737 cytoplasm
GO:0005886 plasma membrane
GO:0005887 integral component of plasma membrane
GO:0006919 activation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0007155 cell adhesion
GO:0007156 homophilic cell adhesion via plasma membrane adhesion molecules
GO:0007399 nervous system development
GO:0007411 axon guidance
GO:0008046 axon guidance receptor activity
GO:0009986 cell surface
GO:0010628 positive regulation of gene expression
GO:0010629 negative regulation of gene expression
GO:0016199 axon midline choice point recognition
GO:0021836 chemorepulsion involved in postnatal olfactory bulb interneuron migration
GO:0030275 LRR domain binding
GO:0030336 negative regulation of cell migration
GO:0030424 axon
GO:0033116 endoplasmic reticulum-Golgi intermediate compartment membrane
GO:0033600 negative regulation of mammary gland epithelial cell proliferation
GO:0035025 positive regulation of Rho protein signal transduction
GO:0035385 Roundabout signaling pathway
GO:0035481 positive regulation of Notch signaling pathway involved in heart induction
GO:0035904 aorta development
GO:0042802 identical protein binding
GO:0043406 positive regulation of MAP kinase activity
GO:0050772 positive regulation of axonogenesis
GO:0050925 negative regulation of negative chemotaxis
GO:0060412 ventricular septum morphogenesis
GO:0070100 negative regulation of chemokine-mediated signaling pathway
GO:1900748 positive regulation of vascular endothelial growth factor signaling pathway

Subcellular Location

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Subcellular Location
Cell membrane
Cell projection
Endoplasmic reticulum-Golgi intermediate compartment membrane

Domains

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DomainNameCategoryType
IPR003598 Immunoglobulin subtype 2DomainDomain
IPR003599 Immunoglobulin subtypeDomainDomain
IPR003961 Fibronectin type IIIDomainDomain
IPR007110 Immunoglobulin-like domainDomainDomain
IPR013098 Immunoglobulin I-setDomainDomain
IPR013106 Immunoglobulin V-set domainDomainDomain
IPR013783 Immunoglobulin-like foldFamilyHomologous superfamily
IPR032986 Roundabout homologue 1FamilyFamily
IPR036116 Fibronectin type III superfamilyFamilyHomologous superfamily
IPR036179 Immunoglobulin-like domain superfamilyFamilyHomologous superfamily

Diseases

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