Entity Details

Primary name GREM1_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionO60565
EntryNameGREM1_HUMAN
FullNameGremlin-1
TaxID9606
Evidenceevidence at protein level
Length184
SequenceStatuscomplete
DateCreated2005-04-12
DateModified2021-06-02

Ontological Relatives

GenesGREM1

GO terms

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GOName
GO:0000902 cell morphogenesis
GO:0002042 cell migration involved in sprouting angiogenesis
GO:0002092 positive regulation of receptor internalization
GO:0003257 positive regulation of transcription from RNA polymerase II promoter involved in myocardial precursor cell differentiation
GO:0003337 mesenchymal to epithelial transition involved in metanephros morphogenesis
GO:0005125 cytokine activity
GO:0005615 extracellular space
GO:0006915 apoptotic process
GO:0007165 signal transduction
GO:0007267 cell-cell signaling
GO:0008284 positive regulation of cell population proliferation
GO:0009887 animal organ morphogenesis
GO:0009954 proximal/distal pattern formation
GO:0009986 cell surface
GO:0010717 regulation of epithelial to mesenchymal transition
GO:0016015 morphogen activity
GO:0030199 collagen fibril organization
GO:0030297 transmembrane receptor protein tyrosine kinase activator activity
GO:0030308 negative regulation of cell growth
GO:0030326 embryonic limb morphogenesis
GO:0030502 negative regulation of bone mineralization
GO:0030514 negative regulation of BMP signaling pathway
GO:0032331 negative regulation of chondrocyte differentiation
GO:0033689 negative regulation of osteoblast proliferation
GO:0036122 BMP binding
GO:0038098 sequestering of BMP from receptor via BMP binding
GO:0042803 protein homodimerization activity
GO:0043066 negative regulation of apoptotic process
GO:0043184 vascular endothelial growth factor receptor 2 binding
GO:0045668 negative regulation of osteoblast differentiation
GO:0045766 positive regulation of angiogenesis
GO:0045892 negative regulation of transcription, DNA-templated
GO:0045944 positive regulation of transcription by RNA polymerase II
GO:0046851 negative regulation of bone remodeling
GO:0048018 receptor ligand activity
GO:0048263 determination of dorsal identity
GO:0051092 positive regulation of NF-kappaB transcription factor activity
GO:0051893 regulation of focal adhesion assembly
GO:0051973 positive regulation of telomerase activity
GO:0060173 limb development
GO:0060394 negative regulation of pathway-restricted SMAD protein phosphorylation
GO:0060676 ureteric bud formation
GO:0062023 collagen-containing extracellular matrix
GO:0090027 negative regulation of monocyte chemotaxis
GO:0090090 negative regulation of canonical Wnt signaling pathway
GO:0090190 positive regulation of branching involved in ureteric bud morphogenesis
GO:0090291 negative regulation of osteoclast proliferation
GO:1900086 positive regulation of peptidyl-tyrosine autophosphorylation
GO:1900155 negative regulation of bone trabecula formation
GO:1900158 negative regulation of bone mineralization involved in bone maturation
GO:1901224 positive regulation of NIK/NF-kappaB signaling
GO:2000273 positive regulation of signaling receptor activity
GO:2000727 positive regulation of cardiac muscle cell differentiation

Subcellular Location

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Subcellular Location
Secreted

Domains

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DomainNameCategoryType
IPR004133 DANDomainDomain
IPR006207 Cystine knot, C-terminalDomainDomain
IPR017159 Gremlin-1/2FamilyFamily
IPR029034 Cystine-knot cytokineFamilyHomologous superfamily

Diseases

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Interactions

5 interactions