Entity Details

Primary name TBL1X_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionO60907
EntryNameTBL1X_HUMAN
FullNameF-box-like/WD repeat-containing protein TBL1X
TaxID9606
Evidenceevidence at protein level
Length577
SequenceStatuscomplete
DateCreated2001-01-11
DateModified2021-06-02

Ontological Relatives

GenesTBL1X

GO terms

Show/Hide Table
GOName
GO:0000118 histone deacetylase complex
GO:0000122 negative regulation of transcription by RNA polymerase II
GO:0000976 transcription cis-regulatory region binding
GO:0003714 transcription corepressor activity
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0006357 regulation of transcription by RNA polymerase II
GO:0006367 transcription initiation from RNA polymerase II promoter
GO:0006508 proteolysis
GO:0007605 sensory perception of sound
GO:0008013 beta-catenin binding
GO:0008022 protein C-terminus binding
GO:0008134 transcription factor binding
GO:0016575 histone deacetylation
GO:0017053 transcription repressor complex
GO:0019216 regulation of lipid metabolic process
GO:0019904 protein domain specific binding
GO:0030522 intracellular receptor signaling pathway
GO:0042393 histone binding
GO:0042802 identical protein binding
GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process
GO:0045893 positive regulation of transcription, DNA-templated
GO:0045944 positive regulation of transcription by RNA polymerase II
GO:0050821 protein stabilization
GO:0072686 mitotic spindle
GO:0090263 positive regulation of canonical Wnt signaling pathway

Subcellular Location

Show/Hide Table
Subcellular Location
Nucleus

Domains

Show/Hide Table
DomainNameCategoryType
IPR001680 WD40 repeatRepeatRepeat
IPR006594 LIS1 homology motifDomainDomain
IPR011047 Quinoprotein alcohol dehydrogenase-like superfamilyFamilyHomologous superfamily
IPR015943 WD40/YVTN repeat-like-containing domain superfamilyFamilyHomologous superfamily
IPR019775 WD40 repeat, conserved siteSiteConserved site
IPR020472 G-protein beta WD-40 repeatRepeatRepeat
IPR036322 WD40-repeat-containing domain superfamilyFamilyHomologous superfamily

Diseases

Show/Hide Table

Interactions

41 interactions

InteractorPartnerSourcesPublicationsLink
TBL1X_HUMANHDAC3_HUMANBioGRID, HPRD, IntAct, UniProt10809664 10944117 11931768 16980585 18202150 21258344 23752268 28348241 details
TBL1X_HUMANTBL1R_HUMANBioGRID, HPRD, IntAct15601853 18202150 18374649 21258344 27880911 details
TBL1X_HUMANDLX3_HUMANBioGRID, IntAct21988832 details
TBL1X_HUMANHPT_HUMANBioGRID, IntAct21988832 details
TBL1X_HUMANKHDR1_HUMANBioGRID, IntAct21988832 details
TBL1X_HUMANDNJB4_HUMANBioGRID, IntAct21988832 details
TBL1X_HUMANCTNB1_HUMANBioGRID, HPRD, IntAct11389839 18193033 25241761 details
TBL1X_HUMANFOXK2_HUMANBioGRID, MINT25609649 27773593 details
TBL1X_HUMANTERF1_HUMANbhf-ucl, BioGRID21044950 details
TBL1X_HUMANTINF2_HUMANbhf-ucl, BioGRID21044950 details
TBL1X_HUMANARL3_HUMANBioGRID, IntAct32296183 details
TBL1X_HUMANGPS2_HUMANBioGRID, DIP, HPRD, IntAct11931768 21240272 24943844 26070566 26186194 28514442 details
TBL1X_HUMANTBL1X_HUMANBioGRID, DIP16258276 21240272 details
TBL1X_HUMANDNJB1_HUMANIntAct32814053 details
TBL1X_HUMANKLF11_HUMANIntAct32814053 details
TBL1X_HUMANHAIR_HUMANBioGRID, IntAct20211142 details
TBL1X_HUMANNCOR1_HUMANBioGRID, HPRD10809664 10944117 11931768 12628926 15601853 18202150 22294699 27880911 details
TBL1X_HUMANNCOR2_HUMANBioGRID, HPRD10809664 10944117 12502735 12628926 21240272 details
TBL1X_HUMANH2B2E_HUMANBioGRID, HPRD12628926 15601853 details
TBL1X_HUMANH4_HUMANBioGRID, HPRD12628926 15601853 30804502 details
TBL1X_HUMANH2A2A_HUMANBioGRID12628926 details
TBL1X_HUMANH32_HUMANBioGRID12628926 details
TBL1X_HUMANTAB2_HUMANBioGRID12150997 details
TBL1X_HUMANTHB_HUMANBioGRID10809664 17242407 details
TBL1X_HUMANSKP1_HUMANBioGRID, HPRD11389839 details
TBL1X_HUMANTHA_HUMANBioGRID17242407 details
TBL1X_HUMANUB2R1_HUMANBioGRID14980219 details
TBL1X_HUMANUB2D1_HUMANBioGRID14980219 details
TBL1X_HUMANUBC9_HUMANBioGRID26369384 details
TBL1X_HUMANMECP2_HUMANBioGRID28348241 details
TBL1X_HUMANCYBP_HUMANBioGRID, IntAct11389839 25241761 details
TBL1X_HUMANHDAC5_HUMANBioGRID, IntAct11931768 21081666 23752268 details
TBL1X_HUMANSIAH1_HUMANBioGRID11389839 details
TBL1X_HUMANCTBP1_HUMANBioGRID18374649 details
TBL1X_HUMANSIN3A_HUMANBioGRID17210713 details
TBL1X_HUMANUB2E3_HUMANBioGRID18202150 details
TBL1X_HUMANEMD_HUMANBioGRID17620012 details
TBL1X_HUMANNRDC_HUMANBioGRID22294699 details
TBL1X_HUMANTF65_HUMANBioGRID21189284 details
TBL1X_HUMANUBP44_HUMANBioGRID27880911 32076268 details
TBL1X_HUMANCOR2A_HUMANHPRD12628926 details