Entity Details

Primary name H2AY_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionO75367
EntryNameH2AY_HUMAN
FullNameCore histone macro-H2A.1
TaxID9606
Evidenceevidence at protein level
Length372
SequenceStatuscomplete
DateCreated2001-01-24
DateModified2021-06-02

Ontological Relatives

GenesMACROH2A1

GO terms

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GOName
GO:0000122 negative regulation of transcription by RNA polymerase II
GO:0000182 rDNA binding
GO:0000228 nuclear chromosome
GO:0000781 chromosome, telomeric region
GO:0000785 chromatin
GO:0000786 nucleosome
GO:0000793 condensed chromosome
GO:0000976 transcription cis-regulatory region binding
GO:0000977 RNA polymerase II transcription regulatory region sequence-specific DNA binding
GO:0000979 RNA polymerase II core promoter sequence-specific DNA binding
GO:0001739 sex chromatin
GO:0001740 Barr body
GO:0003677 DNA binding
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005721 pericentric heterochromatin
GO:0005730 nucleolus
GO:0006334 nucleosome assembly
GO:0006342 chromatin silencing
GO:0007549 dosage compensation
GO:0010385 double-stranded methylated DNA binding
GO:0019216 regulation of lipid metabolic process
GO:0019899 enzyme binding
GO:0019901 protein kinase binding
GO:0030291 protein serine/threonine kinase inhibitor activity
GO:0031490 chromatin DNA binding
GO:0031492 nucleosomal DNA binding
GO:0033128 negative regulation of histone phosphorylation
GO:0034184 positive regulation of maintenance of mitotic sister chromatid cohesion
GO:0040029 regulation of gene expression, epigenetic
GO:0045618 positive regulation of keratinocyte differentiation
GO:0045814 negative regulation of gene expression, epigenetic
GO:0045815 positive regulation of gene expression, epigenetic
GO:0046982 protein heterodimerization activity
GO:0051572 negative regulation of histone H3-K4 methylation
GO:0061086 negative regulation of histone H3-K27 methylation
GO:0070062 extracellular exosome
GO:0071169 establishment of protein localization to chromatin
GO:0071901 negative regulation of protein serine/threonine kinase activity
GO:1901837 negative regulation of transcription of nucleolar large rRNA by RNA polymerase I
GO:1902750 negative regulation of cell cycle G2/M phase transition
GO:1902882 regulation of response to oxidative stress
GO:1902883 negative regulation of response to oxidative stress
GO:1902884 positive regulation of response to oxidative stress
GO:1903226 positive regulation of endodermal cell differentiation
GO:1904815 negative regulation of protein localization to chromosome, telomeric region
GO:1990841 promoter-specific chromatin binding

Subcellular Location

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Subcellular Location
Chromosome
Nucleus

Domains

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DomainNameCategoryType
IPR002119 Histone H2AFamilyFamily
IPR002589 Macro domainDomainDomain
IPR007125 Histone H2A/H2B/H3DomainDomain
IPR009072 Histone-foldFamilyHomologous superfamily
IPR021171 Core histone macro-H2AFamilyFamily
IPR032454 Histone H2A, C-terminal domainDomainDomain
IPR035796 Core histone macro-H2A, macro domainDomainDomain
IPR043472 Macro domain-likeFamilyHomologous superfamily

Diseases

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Interactions

49 interactions

InteractorPartnerSourcesPublicationsLink
H2AY_HUMANATF2_HUMANBioGRID, MINT17036053 details
H2AY_HUMANSRPK1_HUMANBioGRID, IntAct23602568 details
H2AY_HUMANERIC2_HUMANBioGRID, IntAct25416956 32296183 details
H2AY_HUMANPARP1_HUMANBioGRID, HPRD, IntAct17158748 17322296 23473667 25306110 25417162 28242625 34079125 details
H2AY_HUMANKR108_HUMANBioGRID, IntAct32296183 details
H2AY_HUMANTRAF2_HUMANBioGRID, IntAct32296183 details
H2AY_HUMANCRTP1_HUMANBioGRID, IntAct32296183 details
H2AY_HUMANNKAP1_HUMANBioGRID, IntAct32296183 details
H2AY_HUMANSR1IP_HUMANBioGRID, IntAct32296183 details
H2AY_HUMANF133A_HUMANBioGRID, IntAct32296183 details
H2AY_HUMANZN622_HUMANBioGRID, IntAct32296183 details
H2AY_HUMANTRI26_HUMANBioGRID, IntAct32296183 details
H2AY_HUMANBRCA1_HUMANBioGRID, HPRD12419249 28564596 details
H2AY_HUMANHDAC1_HUMANBioGRID16107708 17158748 17474147 details
H2AY_HUMANATX1L_HUMANBioGRID16713569 details
H2AY_HUMANA4_HUMANBioGRID21832049 details
H2AY_HUMANSPOP_HUMANBioGRID, HPRD12183056 28805822 details
H2AY_HUMANBARD1_HUMANBioGRID28564596 details
H2AY_HUMANVCX2_HUMANBioGRID32296183 details
H2AY_HUMANH2B1N_HUMANBioGRID32296183 details
H2AY_HUMANTRI59_HUMANBioGRID31488827 details
H2AY_HUMANRN168_HUMANBioGRID32424115 details
H2AY_HUMANERBB2_HUMANBioGRID, IntAct22589551 details
H2AY_HUMANATRX_HUMANBioGRID, IntAct25417162 26373281 details
H2AY_HUMANTNKS1_HUMANIntAct26373281 details
H2AY_HUMANCENPA_HUMANBioGRID, IntAct15009096 16622419 28514442 34079125 details
H2AY_HUMANAPLF_HUMANBioGRID, IntAct26186194 27067600 28514442 details
H2AY_HUMANH31_HUMANBioGRID, IntAct16622419 23319141 24981860 25417162 28514442 34079125 details
H2AY_HUMANXRCC5_HUMANBioGRID17158748 details
H2AY_HUMANHSP74_HUMANBioGRID17158748 details
H2AY_HUMANMEP50_HUMANBioGRID17158748 details
H2AY_HUMANRCC1_HUMANBioGRID17158748 details
H2AY_HUMANDEK_HUMANBioGRID17158748 details
H2AY_HUMANRAN_HUMANBioGRID17158748 details
H2AY_HUMANPHF14_HUMANBioGRID17158748 28242625 details
H2AY_HUMANTOP1_HUMANBioGRID17158748 details
H2AY_HUMANCUL3_HUMANBioGRID15897469 details
H2AY_HUMANHDAC2_HUMANBioGRID16107708 17474147 28242625 details
H2AY_HUMANH33_HUMANBioGRID23319141 24981860 details
H2AY_HUMANH2B2E_HUMANBioGRID25306110 28242625 details
H2AY_HUMANH31T_HUMANBioGRID25306110 details
H2AY_HUMANH11_HUMANBioGRID25417162 details
H2AY_HUMANH2A1B_HUMANBioGRID25417162 27248496 details
H2AY_HUMANH2B1B_HUMANBioGRID25417162 27248496 details
H2AY_HUMANHPF1_HUMANBioGRID27067600 details
H2AY_HUMANUB2E1_HUMANBioGRID28073915 details
H2AY_HUMANZMYM3_HUMANBioGRID28242625 details
H2AY_HUMANSTAU1_HUMANBioGRID29395067 30948266 details
H2AY_HUMANSOX2_HUMANBioGRID21280222 details