Entity Details

Primary name NR1I2_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionO75469
EntryNameNR1I2_HUMAN
FullNameNuclear receptor subfamily 1 group I member 2
TaxID9606
Evidenceevidence at protein level
Length434
SequenceStatuscomplete
DateCreated1999-07-15
DateModified2021-06-02

Ontological Relatives

GenesNR1I2

GO terms

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GOName
GO:0000122 negative regulation of transcription by RNA polymerase II
GO:0000785 chromatin
GO:0000977 RNA polymerase II transcription regulatory region sequence-specific DNA binding
GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding
GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific
GO:0001228 DNA-binding transcription activator activity, RNA polymerase II-specific
GO:0004879 nuclear receptor activity
GO:0005654 nucleoplasm
GO:0006355 regulation of transcription, DNA-templated
GO:0006367 transcription initiation from RNA polymerase II promoter
GO:0006805 xenobiotic metabolic process
GO:0007165 signal transduction
GO:0008144 drug binding
GO:0008202 steroid metabolic process
GO:0008270 zinc ion binding
GO:0010628 positive regulation of gene expression
GO:0016604 nuclear body
GO:0016922 nuclear receptor binding
GO:0030154 cell differentiation
GO:0042738 exogenous drug catabolic process
GO:0042908 xenobiotic transport
GO:0045111 intermediate filament cytoskeleton
GO:0045892 negative regulation of transcription, DNA-templated
GO:0045893 positive regulation of transcription, DNA-templated
GO:0045944 positive regulation of transcription by RNA polymerase II
GO:1990837 sequence-specific double-stranded DNA binding

Subcellular Location

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Subcellular Location
Nucleus

Domains

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DomainNameCategoryType
IPR000536 Nuclear hormone receptor, ligand-binding domainDomainDomain
IPR001628 Zinc finger, nuclear hormone receptor-typeDomainDomain
IPR001723 Nuclear hormone receptorFamilyFamily
IPR013088 Zinc finger, NHR/GATA-typeFamilyHomologous superfamily
IPR035500 Nuclear hormone receptor-like domain superfamilyFamilyHomologous superfamily

Diseases

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Drugs

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DrugNameSourceType
DB00163 Vitamin EDrugbanksmall molecule
DB00239 OxiconazoleDrugbanksmall molecule
DB00252 PhenytoinDrugbanksmall molecule
DB00255 DiethylstilbestrolDrugbanksmall molecule
DB00257 ClotrimazoleDrugbanksmall molecule
DB00312 PentobarbitalDrugbanksmall molecule
DB00421 SpironolactoneDrugbanksmall molecule
DB00431 LindaneDrugbanksmall molecule
DB00499 FlutamideDrugbanksmall molecule
DB00503 RitonavirDrugbanksmall molecule
DB00530 ErlotinibDrugbanksmall molecule
DB00531 CyclophosphamideDrugbanksmall molecule
DB00532 MephenytoinDrugbanksmall molecule
DB00564 CarbamazepineDrugbanksmall molecule
DB00675 TamoxifenDrugbanksmall molecule
DB00682 WarfarinDrugbanksmall molecule
DB00754 EthotoinDrugbanksmall molecule
DB00783 EstradiolDrugbanksmall molecule
DB00834 MifepristoneDrugbanksmall molecule
DB00849 MethylphenobarbitalDrugbanksmall molecule
DB00977 EthinylestradiolDrugbanksmall molecule
DB01026 KetoconazoleDrugbanksmall molecule
DB01039 FenofibrateDrugbanksmall molecule
DB01045 RifampicinDrugbanksmall molecule
DB01068 ClonazepamDrugbanksmall molecule
DB01110 MiconazoleDrugbanksmall molecule
DB01115 NifedipineDrugbanksmall molecule
DB01127 EconazoleDrugbanksmall molecule
DB01138 SulfinpyrazoneDrugbanksmall molecule
DB01174 PhenobarbitalDrugbanksmall molecule
DB01181 IfosfamideDrugbanksmall molecule
DB01220 RifaximinDrugbanksmall molecule
DB01229 PaclitaxelDrugbanksmall molecule
DB01234 DexamethasoneDrugbanksmall molecule
DB01248 DocetaxelDrugbanksmall molecule
DB01393 BezafibrateDrugbanksmall molecule
DB01645 GenisteinDrugbanksmall molecule
DB01708 PrasteroneDrugbanksmall molecule
DB01892 HyperforinDrugbanksmall molecule
DB02709 ResveratrolDrugbanksmall molecule
DB02789 PregnenoloneDrugbanksmall molecule
DB04216 QuercetinDrugbanksmall molecule
DB04466 SR12813Drugbanksmall molecule
DB04468 AfimoxifeneDrugbanksmall molecule
DB04824 PhenolphthaleinDrugbanksmall molecule
DB04930 PermethrinDrugbanksmall molecule
DB05928 DovitinibDrugbanksmall molecule
DB06777 Chenodeoxycholic acidDrugbanksmall molecule
DB07080 TO-901317Drugbanksmall molecule
DB07931 HexestrolDrugbanksmall molecule
DB08604 TriclosanDrugbanksmall molecule
DB08864 RilpivirineDrugbanksmall molecule
DB11087 Pyrethrum extractDrugbankbiotech
DB11605 MyrrhDrugbanksmall molecule
DB12582 PiperineDrugbanksmall molecule
DB13179 TroleandomycinDrugbanksmall molecule
DB13873 Fenofibric acidDrugbanksmall molecule
DB13952 Estradiol acetateDrugbanksmall molecule
DB13953 Estradiol benzoateDrugbanksmall molecule
DB13954 Estradiol cypionateDrugbanksmall molecule
DB13955 Estradiol dienanthateDrugbanksmall molecule
DB13956 Estradiol valerateDrugbanksmall molecule
DB14001 alpha-Tocopherol succinateDrugbanksmall molecule
DB14002 D-alpha-Tocopherol acetateDrugbanksmall molecule
DB14649 Dexamethasone acetateDrugbanksmall molecule

Interactions

42 interactions

InteractorPartnerSourcesPublicationsLink
NR1I2_HUMANVAS1_HUMANBioGRID, IntAct21988832 details
NR1I2_HUMANFGR_HUMANBioGRID, IntAct21988832 details
NR1I2_HUMANNFAC4_HUMANBioGRID, IntAct21988832 details
NR1I2_HUMANMK07_HUMANBioGRID, IntAct21988832 details
NR1I2_HUMANAP2C_HUMANBioGRID, IntAct21988832 details
NR1I2_HUMANCAB45_HUMANBioGRID, IntAct21988832 details
NR1I2_HUMANNCOA1_HUMANBioGRID, HPRD, IntAct12072427 12909012 15331348 15604093 16455805 17429319 18096694 19171678 23160820 23602807 details
NR1I2_HUMANPIT1_HUMANBioGRID, HPRD11891224 details
NR1I2_HUMANNCOR1_HUMANBioGRID18978041 details
NR1I2_HUMANNCOR2_HUMANBioGRID, HPRD12072427 16144941 16219912 details
NR1I2_HUMANPRGC1_HUMANBioGRID, HPRD15322103 15331348 15604093 16455805 details
NR1I2_HUMANTADA3_HUMANBioGRID20413580 details
NR1I2_HUMANACTN2_HUMANBioGRID, HPRD15604093 details
NR1I2_HUMANCHM1A_HUMANBioGRID15604093 details
NR1I2_HUMANRXRA_HUMANBioGRID, HPRD15604093 22976785 23160820 26855179 9489701 9727070 details
NR1I2_HUMANNUCB2_HUMANBioGRID, HPRD15604093 details
NR1I2_HUMANRXRG_HUMANBioGRID, HPRD15604093 details
NR1I2_HUMANRXRB_HUMANBioGRID, HPRD15604093 23536728 9727070 details
NR1I2_HUMANNCOA6_HUMANBioGRID21292004 details
NR1I2_HUMANNCOA2_HUMANBioGRID23160820 details
NR1I2_HUMANHOIL1_HUMANBioGRID23160820 details
NR1I2_HUMANNCOA3_HUMANBioGRID, HPRD16219912 details
NR1I2_HUMANUBR5_HUMANBioGRID24438055 details
NR1I2_HUMANDYRK2_HUMANBioGRID24438055 details
NR1I2_HUMANKS6B1_HUMANBioGRID19171678 details
NR1I2_HUMANUBC9_HUMANBioGRID20719936 details
NR1I2_HUMANPRS8_HUMANBioGRID, HPRD14702340 15604093 details
NR1I2_HUMANDNM3L_HUMANBioGRID24952347 details
NR1I2_HUMANHNF4A_HUMANBioGRID15331348 16455805 details
NR1I2_HUMANNR0B2_HUMANBioGRID16455805 details
NR1I2_HUMANNR5A2_HUMANBioGRID15331348 details
NR1I2_HUMANEP300_HUMANBioGRID26855179 details
NR1I2_HUMANSRC_HUMANHPRD12072427 details
NR1I2_HUMANHS90B_HUMANIntAct22939624 details
NR1I2_HUMANANM1_HUMANBioGRID19144646 details
NR1I2_HUMANHS90A_HUMANBioGRID22939624 details
NR1I2_HUMANDDB1_HUMANBioGRID24438055 details
NR1I2_HUMANRBBP7_HUMANBioGRID24438055 details
NR1I2_HUMANP53_HUMANBioGRID23536728 details
NR1I2_HUMANCEBPA_HUMANBioGRID20624854 details
NR1I2_HUMANPPIA_HUMANBioGRID25678563 details
NR1I2_HUMANNR1I2_HUMANHPRD12909012 details