Entity Details

Primary name FLOT1_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionO75955
EntryNameFLOT1_HUMAN
FullNameFlotillin-1
TaxID9606
Evidenceevidence at protein level
Length427
SequenceStatuscomplete
DateCreated2001-02-21
DateModified2021-06-02

Ontological Relatives

GenesFLOT1

GO terms

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GOName
GO:0001765 membrane raft assembly
GO:0001819 positive regulation of cytokine production
GO:0001931 uropod
GO:0001934 positive regulation of protein phosphorylation
GO:0002020 protease binding
GO:0002090 regulation of receptor internalization
GO:0005765 lysosomal membrane
GO:0005768 endosome
GO:0005769 early endosome
GO:0005815 microtubule organizing center
GO:0005886 plasma membrane
GO:0005901 caveola
GO:0005911 cell-cell junction
GO:0005912 adherens junction
GO:0005925 focal adhesion
GO:0007409 axonogenesis
GO:0009897 external side of plasma membrane
GO:0016020 membrane
GO:0016323 basolateral plasma membrane
GO:0016600 flotillin complex
GO:0022617 extracellular matrix disassembly
GO:0030027 lamellipodium
GO:0031410 cytoplasmic vesicle
GO:0032092 positive regulation of protein binding
GO:0032226 positive regulation of synaptic transmission, dopaminergic
GO:0032728 positive regulation of interferon-beta production
GO:0033227 dsRNA transport
GO:0034116 positive regulation of heterotypic cell-cell adhesion
GO:0034141 positive regulation of toll-like receptor 3 signaling pathway
GO:0034451 centriolar satellite
GO:0034976 response to endoplasmic reticulum stress
GO:0035023 regulation of Rho protein signal transduction
GO:0035255 ionotropic glutamate receptor binding
GO:0042383 sarcolemma
GO:0042470 melanosome
GO:0044291 cell-cell contact zone
GO:0044854 plasma membrane raft assembly
GO:0045121 membrane raft
GO:0045807 positive regulation of endocytosis
GO:0048643 positive regulation of skeletal muscle tissue development
GO:0048786 presynaptic active zone
GO:0050821 protein stabilization
GO:0051092 positive regulation of NF-kappaB transcription factor activity
GO:0051580 regulation of neurotransmitter uptake
GO:0060355 positive regulation of cell adhesion molecule production
GO:0060544 regulation of necroptotic process
GO:0070062 extracellular exosome
GO:0070528 protein kinase C signaling
GO:0071360 cellular response to exogenous dsRNA
GO:0072659 protein localization to plasma membrane
GO:0098691 dopaminergic synapse
GO:0098978 glutamatergic synapse
GO:0098982 GABA-ergic synapse
GO:1901741 positive regulation of myoblast fusion
GO:1901890 positive regulation of cell junction assembly
GO:1903044 protein localization to membrane raft
GO:2000049 positive regulation of cell-cell adhesion mediated by cadherin

Subcellular Location

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Subcellular Location
Cell membrane
Endosome
Melanosome
Membrane
Membrane raft

Domains

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DomainNameCategoryType
IPR001107 Band 7 domainDomainDomain
IPR027705 Flotillin familyFamilyFamily
IPR036013 Band 7/SPFH domain superfamilyFamilyHomologous superfamily

Diseases

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Interactions

42 interactions

InteractorPartnerSourcesPublicationsLink
FLOT1_HUMANGOLM1_HUMANHPRD, IntAct16169070 details
FLOT1_HUMANFLOT2_HUMANBioGRID, HPRD, IntAct, MINT17113085 22939629 24167781 24809731 30021884 34079125 details
FLOT1_HUMANARGI1_HUMANHPRD, MINT17113085 details
FLOT1_HUMANBBS1_HUMANIntAct18000879 details
FLOT1_HUMANBBS4_HUMANIntAct18000879 details
FLOT1_HUMANBBS2_HUMANIntAct18000879 details
FLOT1_HUMANBBS7_HUMANIntAct18000879 details
FLOT1_HUMANA4_HUMANHPRD, IntAct16480949 details
FLOT1_HUMANCAN10_HUMANBioGRID, IntAct21988832 details
FLOT1_HUMANSRPK1_HUMANBioGRID, IntAct23602568 details
FLOT1_HUMANF90A1_HUMANBioGRID, IntAct32296183 details
FLOT1_HUMANNDK7_HUMANBioGRID, IntAct32296183 details
FLOT1_HUMANBANP_HUMANBioGRID, IntAct32296183 details
FLOT1_HUMANC102B_HUMANBioGRID, IntAct32296183 details
FLOT1_HUMANCOX5B_HUMANBioGRID, IntAct32296183 details
FLOT1_HUMANEMP3_HUMANMINT30614533 details
FLOT1_HUMANHD_HUMANBioGRID, IntAct, UniProt25959826 32814053 details
FLOT1_HUMANPCNA_HUMANUniProt26030842 details
FLOT1_HUMANSRBS1_HUMANBioGRID, HPRD11001060 11481476 15128873 15939299 17548467 details
FLOT1_HUMANCBL_HUMANBioGRID11001060 details
FLOT1_HUMANVINEX_HUMANBioGRID11481476 details
FLOT1_HUMANUBC_HUMANBioGRID16196087 28581508 details
FLOT1_HUMANPSMD4_HUMANBioGRID18164080 details
FLOT1_HUMANNGB_HUMANBioGRID, HPRD15120622 15939299 details
FLOT1_HUMANFRS2_HUMANBioGRID22235335 34079125 details
FLOT1_HUMANSHBG_HUMANBioGRID, HPRD15862967 details
FLOT1_HUMANAURKB_HUMANBioGRID20430883 details
FLOT1_HUMANINCE_HUMANBioGRID20430883 details
FLOT1_HUMANHGS_HUMANBioGRID28581508 details
FLOT1_HUMANCAV1_HUMANBioGRID, IntAct10212252 22936677 25204797 34079125 details
FLOT1_HUMANBACE1_HUMANMINT24612608 details
FLOT1_HUMANABCA1_HUMANbhf-ucl, BioGRID15469992 details
FLOT1_HUMANSRBS2_HUMANBioGRID, HPRD15128873 details
FLOT1_HUMANUBXN6_HUMANBioGRID22337587 details
FLOT1_HUMANVATB1_HUMANBioGRID21674799 details
FLOT1_HUMANYES_HUMANBioGRID22936677 details
FLOT1_HUMANSVIL_HUMANBioGRID, HPRD12202484 details
FLOT1_HUMANPTOV1_HUMANBioGRID15713644 details
FLOT1_HUMANABCE1_HUMANBioGRID25659154 details
FLOT1_HUMANU2AF2_HUMANBioGRID26641092 details
FLOT1_HUMANISG15_HUMANBioGRID33024031 details
FLOT1_HUMANFYN_HUMANHPRD11598189 details