Entity Details

Primary name ATG7_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionO95352
EntryNameATG7_HUMAN
FullNameUbiquitin-like modifier-activating enzyme ATG7
TaxID9606
Evidenceevidence at protein level
Length703
SequenceStatuscomplete
DateCreated2005-03-29
DateModified2021-06-02

Ontological Relatives

GenesATG7

GO terms

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GOName
GO:0000045 autophagosome assembly
GO:0000407 phagophore assembly site
GO:0000422 autophagy of mitochondrion
GO:0005576 extracellular region
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0005930 axoneme
GO:0006497 protein lipidation
GO:0006501 C-terminal protein lipidation
GO:0006914 autophagy
GO:0006995 cellular response to nitrogen starvation
GO:0007568 aging
GO:0008134 transcription factor binding
GO:0009267 cellular response to starvation
GO:0009749 response to glucose
GO:0010508 positive regulation of autophagy
GO:0015031 protein transport
GO:0016236 macroautophagy
GO:0019778 Atg12 activating enzyme activity
GO:0019779 Atg8 activating enzyme activity
GO:0030424 axon
GO:0031401 positive regulation of protein modification process
GO:0032446 protein modification by small protein conjugation
GO:0034727 piecemeal microautophagy of the nucleus
GO:0034774 secretory granule lumen
GO:0039521 suppression by virus of host autophagy
GO:0042752 regulation of circadian rhythm
GO:0042803 protein homodimerization activity
GO:0043065 positive regulation of apoptotic process
GO:0043312 neutrophil degranulation
GO:0044805 late nucleophagy
GO:0045732 positive regulation of protein catabolic process
GO:0048511 rhythmic process
GO:0051607 defense response to virus
GO:0061684 chaperone-mediated autophagy
GO:0071315 cellular response to morphine
GO:0071455 cellular response to hyperoxia
GO:0075044 positive regulation by symbiont of host autophagy
GO:0090298 negative regulation of mitochondrial DNA replication
GO:1902617 response to fluoride
GO:1903204 negative regulation of oxidative stress-induced neuron death
GO:1904813 ficolin-1-rich granule lumen

Subcellular Location

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Subcellular Location
Cytoplasm
Preautophagosomal structure

Domains

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DomainNameCategoryType
IPR000594 THIF-type NAD/FAD binding foldDomainDomain
IPR006285 Ubiquitin-like modifier-activating enzyme Atg7FamilyFamily
IPR032197 Ubiquitin-like modifier-activating enzyme Atg7, N-terminalDomainDomain
IPR035985 Ubiquitin-activating enzymeFamilyHomologous superfamily
IPR042522 Ubiquitin-like modifier-activating enzyme Atg7, N-terminal, subdomain 1FamilyHomologous superfamily
IPR042523 Ubiquitin-like modifier-activating enzyme Atg7, N-terminal, subdomain 2FamilyHomologous superfamily

Diseases

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Interactions

24 interactions

InteractorPartnerSourcesPublicationsLink
ATG7_HUMANMLP3B_HUMANBioGRID, HPRD, IntAct11890701 15355958 16303767 18083104 20562859 24023838 30806153 31006538 details
ATG7_HUMANGBRAP_HUMANBioGRID, HPRD, IntAct11096062 11890701 16303767 20562859 25126726 details
ATG7_HUMANGBRL2_HUMANBioGRID, HPRD, IntAct11096062 11890701 16303767 20562859 details
ATG7_HUMANEF1D_HUMANBioGRID, IntAct20195357 details
ATG7_HUMANGBRL1_HUMANBioGRID, IntAct16704426 20562859 details
ATG7_HUMANMLP3A_HUMANBioGRID, IntAct11096062 16303767 20562859 25601754 29033323 31857589 details
ATG7_HUMANMLP3C_HUMANBioGRID, IntAct20562859 31857374 details
ATG7_HUMANATG3_HUMANBioGRID, HPRD, IntAct11825910 20562859 24186333 26043688 28514442 details
ATG7_HUMANATG12_HUMANBioGRID, HPRD, IntAct11096062 11890701 12482611 20562859 28253953 details
ATG7_HUMANATG10_HUMANBioGRID, HPRD, IntAct12482611 20562859 26186194 28514442 details
ATG7_HUMANIRF2_HUMANBioGRID, IntAct21903422 details
ATG7_HUMANSIR1_HUMANBioGRID, DIP18296641 31072129 details
ATG7_HUMANTADBP_HUMANIntAct32814053 details
ATG7_HUMANA4_HUMANBioGRID21832049 details
ATG7_HUMANP53_HUMANDIP22499945 details
ATG7_HUMANFOXO1_HUMANBioGRID20543840 22622204 23640897 30689742 details
ATG7_HUMANSQSTM_HUMANBioGRID22674379 details
ATG7_HUMANEP300_HUMANBioGRID19124466 details
ATG7_HUMANPSD10_HUMANBioGRID25905985 details
ATG7_HUMANLYN_HUMANBioGRID27742708 details
ATG7_HUMANVP13A_HUMANBioGRID27742708 details
ATG7_HUMANKPCD_HUMANBioGRID30589566 30690837 details
ATG7_HUMANCASP9_HUMANBioGRID24362031 details
ATG7_HUMANGSDMD_HUMANBioGRID32597834 details