Entity Details

Primary name SYFM_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionO95363
EntryNameSYFM_HUMAN
FullNamePhenylalanine--tRNA ligase, mitochondrial
TaxID9606
Evidenceevidence at protein level
Length451
SequenceStatuscomplete
DateCreated2004-11-23
DateModified2021-06-02

Ontological Relatives

GenesFARS2

GO terms

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GOName
GO:0000049 tRNA binding
GO:0004826 phenylalanine-tRNA ligase activity
GO:0005524 ATP binding
GO:0005737 cytoplasm
GO:0005739 mitochondrion
GO:0005759 mitochondrial matrix
GO:0006418 tRNA aminoacylation for protein translation
GO:0006432 phenylalanyl-tRNA aminoacylation
GO:0008033 tRNA processing

Subcellular Location

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Subcellular Location
Mitochondrion
Mitochondrion matrix

Domains

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DomainNameCategoryType
IPR002319 Phenylalanyl-tRNA synthetaseDomainDomain
IPR004530 Phenylalanyl-tRNA synthetase, class IIc, mitochondrialFamilyFamily
IPR005121 Ferrodoxin-fold anticodon-binding domainDomainDomain
IPR006195 Aminoacyl-tRNA synthetase, class IIDomainDomain
IPR036690 Ferrodoxin-fold anticodon-binding domain superfamilyFamilyHomologous superfamily

Diseases

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Disease IDSourceNameDescription
614946 OMIMCombined oxidative phosphorylation deficiency 14 (COXPD14)A severe multisystemic autosomal recessive disorder characterized by neonatal onset of global developmental delay, refractory seizures, and lactic acidosis. Biochemical studies show deficiencies of multiple mitochondrial respiratory enzymes. The disease is caused by variants affecting the gene represented in this entry.
617046 OMIMSpastic paraplegia 77, autosomal recessive (SPG77)A form of spastic paraplegia, a neurodegenerative disorder characterized by a slow, gradual, progressive weakness and spasticity of the lower limbs. Rate of progression and the severity of symptoms are quite variable. Initial symptoms may include difficulty with balance, weakness and stiffness in the legs, muscle spasms, and dragging the toes when walking. In some forms of the disorder, bladder symptoms (such as incontinence) may appear, or the weakness and stiffness may spread to other parts of the body. The disease is caused by variants affecting the gene represented in this entry.

Drugs

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DrugNameSourceType
DB00120 PhenylalanineDrugbanksmall molecule

Interactions

73 interactions

InteractorPartnerSourcesPublicationsLink
SYFM_HUMANSTX11_HUMANBioGRID, IntAct25416956 details
SYFM_HUMANTRI27_HUMANBioGRID, IntAct25416956 details
SYFM_HUMANTAD2A_HUMANBioGRID, IntAct25416956 details
SYFM_HUMANRCBT2_HUMANBioGRID, IntAct25416956 32296183 details
SYFM_HUMANKR109_HUMANBioGRID, IntAct25416956 32296183 details
SYFM_HUMANCACO2_HUMANBioGRID, IntAct25416956 31515488 32296183 details
SYFM_HUMANKR105_HUMANIntAct25416956 details
SYFM_HUMANKR107_HUMANBioGRID, IntAct25416956 32296183 details
SYFM_HUMANMKRN3_HUMANBioGRID, IntAct25416956 details
SYFM_HUMANK1C40_HUMANBioGRID, IntAct25416956 32296183 details
SYFM_HUMANATRAP_HUMANBioGRID, IntAct25416956 32296183 details
SYFM_HUMANK1H1_HUMANBioGRID, IntAct25416956 details
SYFM_HUMANTFCP2_HUMANBioGRID, IntAct25416956 details
SYFM_HUMANATL4_HUMANBioGRID, IntAct25416956 details
SYFM_HUMANCKLF5_HUMANBioGRID, IntAct25416956 32296183 details
SYFM_HUMANTRIM1_HUMANBioGRID, IntAct25416956 32296183 details
SYFM_HUMANCBY2_HUMANBioGRID, IntAct32296183 details
SYFM_HUMANZN526_HUMANBioGRID, IntAct32296183 details
SYFM_HUMANHMBX1_HUMANBioGRID, IntAct25416956 details
SYFM_HUMANDP13A_HUMANBioGRID, IntAct25416956 31515488 32296183 details
SYFM_HUMANDG2L6_HUMANBioGRID, IntAct32296183 details
SYFM_HUMANDPH2_HUMANBioGRID, IntAct32296183 details
SYFM_HUMANSPY1_HUMANBioGRID, IntAct32296183 details
SYFM_HUMANNT2NA_HUMANBioGRID, IntAct25416956 details
SYFM_HUMANZRAN1_HUMANBioGRID, IntAct32296183 details
SYFM_HUMANIKZF3_HUMANBioGRID, IntAct25416956 32296183 details
SYFM_HUMANTPM2_HUMANBioGRID, IntAct32296183 details
SYFM_HUMANTRIP6_HUMANBioGRID, IntAct32296183 details
SYFM_HUMANPP16B_HUMANBioGRID, IntAct32296183 details
SYFM_HUMANTRI54_HUMANBioGRID, IntAct25416956 details
SYFM_HUMANBAG4_HUMANBioGRID, IntAct32296183 details
SYFM_HUMANISY1_HUMANBioGRID, IntAct32296183 details
SYFM_HUMANCRTP1_HUMANBioGRID, IntAct32296183 details
SYFM_HUMANCC152_HUMANBioGRID, IntAct32296183 details
SYFM_HUMANKR108_HUMANBioGRID, IntAct32296183 details
SYFM_HUMANMDFI_HUMANBioGRID, IntAct32296183 details
SYFM_HUMANBACH2_HUMANBioGRID, IntAct32296183 details
SYFM_HUMANDVL3_HUMANBioGRID, IntAct32296183 details
SYFM_HUMANKRA11_HUMANBioGRID, IntAct32296183 details
SYFM_HUMANRAB43_HUMANIntAct32296183 details
SYFM_HUMANFHL5_HUMANBioGRID, IntAct32296183 details
SYFM_HUMANSYPH_HUMANBioGRID, IntAct32296183 details
SYFM_HUMANIKBD_HUMANBioGRID, IntAct32296183 details
SYFM_HUMANMESD_HUMANBioGRID, IntAct32296183 details
SYFM_HUMANBANP_HUMANBioGRID, IntAct32296183 details
SYFM_HUMANAP1B1_HUMANBioGRID, IntAct32296183 details
SYFM_HUMANZN655_HUMANBioGRID, IntAct32296183 details
SYFM_HUMANZN438_HUMANBioGRID, IntAct32296183 details
SYFM_HUMANFSD2_HUMANBioGRID, IntAct32296183 details
SYFM_HUMANMORN3_HUMANBioGRID, IntAct32296183 details
SYFM_HUMANRIM3A_HUMANIntAct32296183 details
SYFM_HUMANKCNF1_HUMANBioGRID, IntAct32296183 details
SYFM_HUMANKRA33_HUMANBioGRID, IntAct32296183 details
SYFM_HUMANTRAF2_HUMANBioGRID, IntAct32296183 details
SYFM_HUMANKRT34_HUMANBioGRID, IntAct32296183 details
SYFM_HUMANAJUBA_HUMANBioGRID, IntAct32296183 details
SYFM_HUMANMA1C1_HUMANBioGRID, IntAct32296183 details
SYFM_HUMANCDCA4_HUMANBioGRID, IntAct32296183 details
SYFM_HUMANGRB10_HUMANBioGRID, IntAct32296183 details
SYFM_HUMANHIG1C_HUMANBioGRID, IntAct32296183 details
SYFM_HUMANBEX5_HUMANBioGRID, IntAct32296183 details
SYFM_HUMANPCSK5_HUMANBioGRID, IntAct32296183 details
SYFM_HUMANAP4AT_HUMANBioGRID, IntAct32296183 details
SYFM_HUMANFKBP7_HUMANBioGRID, IntAct32296183 details
SYFM_HUMANKCD17_HUMANBioGRID, IntAct32296183 details
SYFM_HUMANK1C13_HUMANBioGRID25416956 details
SYFM_HUMANYIF1A_HUMANBioGRID, IntAct32296183 details
SYFM_HUMANHOMEZ_HUMANBioGRID32296183 details
SYFM_HUMANMTUS2_HUMANIntAct30886144 details
SYFM_HUMANZN500_HUMANBioGRID, IntAct32296183 details
SYFM_HUMANKR103_HUMANBioGRID25416956 details
SYFM_HUMANNT2NC_HUMANBioGRID25416956 details
SYFM_HUMANRIM3C_HUMANBioGRID32296183 details