Entity Details

Primary name M4K4_HUMAN
Entity type UniProt
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Details

AccessionO95819
EntryNameM4K4_HUMAN
FullNameMitogen-activated protein kinase kinase kinase kinase 4
TaxID9606
Evidenceevidence at protein level
Length1239
SequenceStatuscomplete
DateCreated2003-03-28
DateModified2021-06-02

Ontological Relatives

GenesMAP4K4

GO terms

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GOName
GO:0000165 MAPK cascade
GO:0001953 negative regulation of cell-matrix adhesion
GO:0004111 creatine kinase activity
GO:0004674 protein serine/threonine kinase activity
GO:0005524 ATP binding
GO:0005737 cytoplasm
GO:0005925 focal adhesion
GO:0006468 protein phosphorylation
GO:0008017 microtubule binding
GO:0030335 positive regulation of cell migration
GO:0031098 stress-activated protein kinase signaling cascade
GO:0032014 positive regulation of ARF protein signal transduction
GO:0032147 activation of protein kinase activity
GO:0035556 intracellular signal transduction
GO:0043066 negative regulation of apoptotic process
GO:0043547 positive regulation of GTPase activity
GO:0046328 regulation of JNK cascade
GO:0048812 neuron projection morphogenesis
GO:0051549 positive regulation of keratinocyte migration
GO:0051894 positive regulation of focal adhesion assembly
GO:0106310 protein serine kinase activity
GO:0106311 protein threonine kinase activity
GO:0120183 positive regulation of focal adhesion disassembly

Subcellular Location

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Subcellular Location
Cytoplasm

Domains

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DomainNameCategoryType
IPR000719 Protein kinase domainDomainDomain
IPR001180 Citron homology (CNH) domainDomainDomain
IPR008271 Serine/threonine-protein kinase, active siteSiteActive site
IPR011009 Protein kinase-like domain superfamilyFamilyHomologous superfamily
IPR017441 Protein kinase, ATP binding siteSiteBinding site

Diseases

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Drugs

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DrugNameSourceType
DB12010 FostamatinibDrugbanksmall molecule