Entity Details

Primary name SODC_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionP00441
EntryNameSODC_HUMAN
FullNameSuperoxide dismutase [Cu-Zn]
TaxID9606
Evidenceevidence at protein level
Length154
SequenceStatuscomplete
DateCreated1986-07-21
DateModified2021-06-02

Ontological Relatives

GenesSOD1

GO terms

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GOName
GO:0005764 lysosome
GO:0005634 nucleus
GO:0005758 mitochondrial intermembrane space
GO:0032930 positive regulation of superoxide anion generation
GO:0043065 positive regulation of apoptotic process
GO:0048678 response to axon injury
GO:0060047 heart contraction
GO:0006801 superoxide metabolic process
GO:0008270 zinc ion binding
GO:0032839 dendrite cytoplasm
GO:0034599 cellular response to oxidative stress
GO:0051881 regulation of mitochondrial membrane potential
GO:0060088 auditory receptor cell stereocilium organization
GO:0002262 myeloid cell homeostasis
GO:0007626 locomotory behavior
GO:0034465 response to carbon monoxide
GO:0035865 cellular response to potassium ion
GO:0072593 reactive oxygen species metabolic process
GO:0000303 response to superoxide
GO:0008090 retrograde axonal transport
GO:0032287 peripheral nervous system myelin maintenance
GO:0042493 response to drug
GO:0042802 identical protein binding
GO:0046677 response to antibiotic
GO:0060052 neurofilament cytoskeleton organization
GO:0071318 cellular response to ATP
GO:0006879 cellular iron ion homeostasis
GO:0007283 spermatogenesis
GO:0030346 protein phosphatase 2B binding
GO:0031267 small GTPase binding
GO:1902177 positive regulation of oxidative stress-induced intrinsic apoptotic signaling pathway
GO:0005759 mitochondrial matrix
GO:0043087 regulation of GTPase activity
GO:0046620 regulation of organ growth
GO:0060087 relaxation of vascular associated smooth muscle
GO:0033081 regulation of T cell differentiation in thymus
GO:0050728 negative regulation of inflammatory response
GO:0097332 response to antipsychotic drug
GO:0001890 placenta development
GO:0005777 peroxisome
GO:0008089 anterograde axonal transport
GO:0019226 transmission of nerve impulse
GO:0031045 dense core granule
GO:0032991 protein-containing complex
GO:1904115 axon cytoplasm
GO:0004784 superoxide dismutase activity
GO:0005507 copper ion binding
GO:0019430 removal of superoxide radicals
GO:0001541 ovarian follicle development
GO:0005737 cytoplasm
GO:0031667 response to nutrient levels
GO:0071276 cellular response to cadmium ion
GO:0005576 extracellular region
GO:0007569 cell aging
GO:0007605 sensory perception of sound
GO:0043085 positive regulation of catalytic activity
GO:0046716 muscle cell cellular homeostasis
GO:0001975 response to amphetamine
GO:0005615 extracellular space
GO:0045541 negative regulation of cholesterol biosynthetic process
GO:0001895 retina homeostasis
GO:0005739 mitochondrion
GO:0010033 response to organic substance
GO:0043025 neuronal cell body
GO:0045859 regulation of protein kinase activity
GO:0046688 response to copper ion
GO:0050665 hydrogen peroxide biosynthetic process
GO:0035722 interleukin-12-mediated signaling pathway
GO:0009408 response to heat
GO:0042542 response to hydrogen peroxide
GO:0050766 positive regulation of phagocytosis
GO:0051087 chaperone binding
GO:0070062 extracellular exosome
GO:0000187 obsolete activation of MAPK activity
GO:0006749 glutathione metabolic process
GO:0008217 regulation of blood pressure
GO:0045471 response to ethanol
GO:0040014 regulation of multicellular organism growth
GO:0043524 negative regulation of neuron apoptotic process
GO:0048538 thymus development
GO:0002576 platelet degranulation
GO:0005654 nucleoplasm
GO:0031410 cytoplasmic vesicle
GO:0001819 positive regulation of cytokine production
GO:0005829 cytosol
GO:0007566 embryo implantation
GO:0042554 superoxide anion generation

Subcellular Location

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Subcellular Location
Cytoplasm
Mitochondrion
Nucleus

Domains

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DomainNameCategoryType
IPR001424 Superoxide dismutase, copper/zinc binding domainDomainDomain
IPR018152 Superoxide dismutase, copper/zinc, binding siteSiteBinding site
IPR024134 Superoxide dismutase (Cu/Zn) / superoxide dismutase copper chaperoneFamilyFamily
IPR036423 Superoxide dismutase-like, copper/zinc binding domain superfamilyFamilyHomologous superfamily

Diseases

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Drugs

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DrugNameSourceType
DB00163 Vitamin EDrugbanksmall molecule
DB00515 CisplatinDrugbanksmall molecule
DB00526 OxaliplatinSwissprotsmall molecule
DB00958 CarboplatinSwissprotsmall molecule
DB00988 DopamineDrugbanksmall molecule
DB01064 IsoprenalineDrugbanksmall molecule
DB01593 ZincDrugbanksmall molecule
DB01629 5-fluorouridineDrugbanksmall molecule
DB03382 S-oxy-L-cysteineDrugbanksmall molecule
DB05025 ArimoclomolDrugbanksmall molecule
DB09061 CannabidiolDrugbanksmall molecule
DB09130 CopperDrugbanksmall molecule
DB09221 PolaprezincDrugbanksmall molecule
DB14001 alpha-Tocopherol succinateDrugbanksmall molecule
DB14002 D-alpha-Tocopherol acetateDrugbanksmall molecule
DB14009 Medical CannabisDrugbankbiotech
DB14011 NabiximolsDrugbanksmall molecule
DB14487 Zinc acetateDrugbanksmall molecule
DB14533 Zinc chlorideDrugbanksmall molecule
DB14548 Zinc sulfate, unspecified formDrugbanksmall molecule

Interactions

100 interactions

InteractorPartnerSourcesPublicationsLink
SODC_HUMANPARK7_HUMANBioGRID, IntAct20406884 24947010 24981860 29128334 31536960 details
SODC_HUMANPRS4_HUMANBioGRID, IntAct29128334 32814053 details
SODC_HUMANRN19A_HUMANBioGRID, HPRD, IntAct12145308 17157513 17666395 32814053 details
SODC_HUMANDYLT1_HUMANBioGRID21252941 details
SODC_HUMANCRYAB_HUMANBioGRID22993064 details
SODC_HUMANHSP74_HUMANBioGRID, IntAct15198682 15358145 17992192 29128334 details
SODC_HUMANTBB5_HUMANIntAct32814053 details
SODC_HUMANCO9_HUMANIntAct32814053 details
SODC_HUMANDAB2_HUMANIntAct32814053 details
SODC_HUMANOTU7B_HUMANIntAct32814053 details
SODC_HUMANCCS_HUMANBioGRID, HPRD, IntAct, MINT10677207 12968035 20154138 22508683 24981860 26344197 26496610 28514442 30735496 9726962 details
SODC_HUMANBCL2_HUMANBioGRID, HPRD, IntAct15233914 32814053 details
SODC_HUMANRBBP4_HUMANIntAct32814053 details
SODC_HUMANSPT22_HUMANIntAct32814053 details
SODC_HUMANRYBP_HUMANIntAct32814053 details
SODC_HUMANSYMPK_HUMANIntAct32814053 details
SODC_HUMANSODC_HUMANBioGRID, DIP, HPRD, MINT12754496 1463506 17592131 19022905 19171884 19369197 19828437 21257910 22993064 23831581 24691167 30735496 31999698 details
SODC_HUMANLSM8_HUMANIntAct32814053 details
SODC_HUMANANXA8_HUMANIntAct32814053 details
SODC_HUMANSYK_HUMANHPRD, IntAct18715867 32814053 details
SODC_HUMANUBP2_HUMANIntAct32814053 details
SODC_HUMANGPSM3_HUMANIntAct32814053 details
SODC_HUMANSEM1_HUMANIntAct32814053 details
SODC_HUMANBAK_HUMANIntAct32814053 details
SODC_HUMANKLH36_HUMANIntAct32814053 details
SODC_HUMANTBL1R_HUMANIntAct32814053 details
SODC_HUMANRPP25_HUMANIntAct32814053 details
SODC_HUMANCBLB_HUMANIntAct32814053 details
SODC_HUMANMPND_HUMANIntAct32814053 details
SODC_HUMANRSSA_HUMANIntAct32814053 details
SODC_HUMANSP6_HUMANIntAct32814053 details
SODC_HUMANENKUR_HUMANIntAct32814053 details
SODC_HUMANSYUA_HUMANBioGRID26643113 details
SODC_HUMANSMAD2_HUMANBioGRID, IntAct20195357 details
SODC_HUMANIN35_HUMANIntAct32814053 details
SODC_HUMANPSB8_HUMANIntAct32814053 details
SODC_HUMANHXC4_HUMANIntAct32814053 details
SODC_HUMANSGSM1_HUMANIntAct32814053 details
SODC_HUMANPP2BA_HUMANHPRD, IntAct11513882 32814053 details
SODC_HUMANAP2B1_HUMANIntAct32814053 details
SODC_HUMANRN112_HUMANIntAct32814053 details
SODC_HUMANZMAT2_HUMANIntAct32814053 details
SODC_HUMANTERF2_HUMANIntAct32814053 details
SODC_HUMANCF141_HUMANIntAct32814053 details
SODC_HUMANLNX2_HUMANIntAct32814053 details
SODC_HUMANZMYM6_HUMANIntAct32814053 details
SODC_HUMANUBB_HUMANIntAct32814053 details
SODC_HUMANHUMMR_HUMANIntAct32814053 details
SODC_HUMANLDH6B_HUMANBioGRID, IntAct26344197 32814053 details
SODC_HUMANFIBA_HUMANIntAct32814053 details
SODC_HUMANBACD2_HUMANIntAct32814053 details
SODC_HUMANZSCA1_HUMANIntAct32814053 details
SODC_HUMANLMBL3_HUMANIntAct32814053 details
SODC_HUMANGBB2_HUMANIntAct32814053 details
SODC_HUMANKKCC1_HUMANIntAct32814053 details
SODC_HUMANCOMD1_HUMANBioGRID20595380 24691167 details
SODC_HUMANOTUB1_HUMANIntAct32814053 details
SODC_HUMANTMX1_HUMANIntAct32814053 details
SODC_HUMANPRS6B_HUMANIntAct32814053 details
SODC_HUMANIQEC1_HUMANIntAct32814053 details
SODC_HUMANKC1D_HUMANIntAct32814053 details
SODC_HUMANPRS6A_HUMANIntAct32814053 details
SODC_HUMANSF3B3_HUMANIntAct32814053 details
SODC_HUMANWDR61_HUMANIntAct32814053 details
SODC_HUMANRAC1_HUMANUniProt18219391 details
SODC_HUMANCRBA2_HUMANIntAct32814053 details
SODC_HUMANZXDC_HUMANIntAct32814053 details
SODC_HUMANPDZ1I_HUMANIntAct32814053 details
SODC_HUMANARL16_HUMANIntAct32814053 details
SODC_HUMANRN111_HUMANIntAct32814053 details
SODC_HUMANTPM2_HUMANIntAct32814053 details
SODC_HUMANHNRLL_HUMANIntAct32814053 details
SODC_HUMANPBX4_HUMANIntAct32814053 details
SODC_HUMANITBP1_HUMANIntAct32814053 details
SODC_HUMANKBTB4_HUMANIntAct32814053 details
SODC_HUMANSTAC3_HUMANIntAct32814053 details
SODC_HUMANUBE3A_HUMANBioGRID23040663 details
SODC_HUMANMARH5_HUMANBioGRID19741096 details
SODC_HUMANAMFR_HUMANBioGRID19661182 details
SODC_HUMANG3P_HUMANBioGRID, IntAct26344197 29128334 details
SODC_HUMANGIMA6_HUMANIntAct32814053 details
SODC_HUMANHDAC6_HUMANBioGRID23580651 details
SODC_HUMANEF1D_HUMANBioGRID, IntAct20195357 29128334 details
SODC_HUMANHSP7C_HUMANBioGRID15358145 28215707 details
SODC_HUMANHECW1_HUMANBioGRID14684739 details
SODC_HUMANNBR1_HUMANMINT21252941 details
SODC_HUMANDNJB1_HUMANHPRD11457725 details
SODC_HUMANSQSTM_HUMANMINT21252941 details
SODC_HUMANBAG3_HUMANMINT21252941 details
SODC_HUMANSSRD_HUMANBioGRID14684739 details
SODC_HUMANPSMD4_HUMANBioGRID15358145 details
SODC_HUMANCHIP_HUMANBioGRID15358145 17157513 details
SODC_HUMANDCTN2_HUMANMINT21252941 details
SODC_HUMANHXB2_HUMANHPRD16079151 details
SODC_HUMANOPTN_HUMANBioGRID23178947 32014991 details
SODC_HUMANLAMP2_HUMANMINT21252941 details
SODC_HUMANUBC_HUMANBioGRID15198682 details
SODC_HUMANMYCB2_HUMANMINT21653829 details
SODC_HUMANDC2L1_HUMANMINT21252941 details
SODC_HUMANDCAF4_HUMANBioGRID32014991 details