Entity Details

Primary name CD4_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionP01730
EntryNameCD4_HUMAN
FullNameT-cell surface glycoprotein CD4
TaxID9606
Evidenceevidence at protein level
Length458
SequenceStatuscomplete
DateCreated1986-07-21
DateModified2021-06-02

Ontological Relatives

GenesCD4

GO terms

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GOName
GO:0050690 regulation of defense response to virus by virus
GO:0019064 fusion of virus membrane with host plasma membrane
GO:0045657 positive regulation of monocyte differentiation
GO:0045121 membrane raft
GO:0050850 positive regulation of calcium-mediated signaling
GO:0019865 immunoglobulin binding
GO:0032355 response to estradiol
GO:0050863 regulation of T cell activation
GO:0004888 transmembrane signaling receptor activity
GO:0010524 positive regulation of calcium ion transport into cytosol
GO:0015026 coreceptor activity
GO:0019221 cytokine-mediated signaling pathway
GO:0042803 protein homodimerization activity
GO:0002250 adaptive immune response
GO:0019901 protein kinase binding
GO:0045860 positive regulation of protein kinase activity
GO:0006948 induction by virus of host cell-cell fusion
GO:0007155 cell adhesion
GO:0030225 macrophage differentiation
GO:0042012 interleukin-16 receptor activity
GO:0097011 cellular response to granulocyte macrophage colony-stimulating factor stimulus
GO:0005789 endoplasmic reticulum membrane
GO:0005886 plasma membrane
GO:0046598 positive regulation of viral entry into host cell
GO:0050731 positive regulation of peptidyl-tyrosine phosphorylation
GO:0061024 membrane organization
GO:0001618 virus receptor activity
GO:0001934 positive regulation of protein phosphorylation
GO:0005769 early endosome
GO:0043410 positive regulation of MAPK cascade
GO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway
GO:0035723 interleukin-15-mediated signaling pathway
GO:0042110 T cell activation
GO:0007165 signal transduction
GO:0019899 enzyme binding
GO:0042289 MHC class II protein binding
GO:0043123 positive regulation of I-kappaB kinase/NF-kappaB signaling
GO:0005788 endoplasmic reticulum lumen
GO:0042802 identical protein binding
GO:0030669 clathrin-coated endocytic vesicle membrane
GO:0033280 response to vitamin D
GO:0042011 interleukin-16 binding
GO:0045893 positive regulation of transcription, DNA-templated
GO:0007167 enzyme linked receptor protein signaling pathway
GO:0008270 zinc ion binding
GO:0050852 T cell receptor signaling pathway
GO:0032507 maintenance of protein location in cell
GO:0045058 T cell selection
GO:0009897 external side of plasma membrane
GO:0030217 T cell differentiation
GO:0042101 T cell receptor complex
GO:0005887 integral component of plasma membrane
GO:0023026 MHC class II protein complex binding
GO:0035397 helper T cell enhancement of adaptive immune response
GO:0038023 signaling receptor activity
GO:0070374 positive regulation of ERK1 and ERK2 cascade
GO:1990782 protein tyrosine kinase binding
GO:0033674 positive regulation of kinase activity
GO:0051924 regulation of calcium ion transport
GO:0005201 extracellular matrix structural constituent
GO:0032743 positive regulation of interleukin-2 production
GO:0006955 immune response
GO:0007166 cell surface receptor signaling pathway
GO:0042102 positive regulation of T cell proliferation
GO:0044409 entry into host
GO:0050829 defense response to Gram-negative bacterium

Subcellular Location

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Subcellular Location
Cell membrane

Domains

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DomainNameCategoryType
IPR000973 T-cell surface antigen CD4FamilyFamily
IPR003598 Immunoglobulin subtype 2DomainDomain
IPR003599 Immunoglobulin subtypeDomainDomain
IPR007110 Immunoglobulin-like domainDomainDomain
IPR008424 Immunoglobulin C2-setDomainDomain
IPR013106 Immunoglobulin V-set domainDomainDomain
IPR013151 ImmunoglobulinDomainDomain
IPR013783 Immunoglobulin-like foldFamilyHomologous superfamily
IPR015274 CD4, extracellularDomainDomain
IPR021963 T cell CD4 receptor C-terminal regionDomainDomain
IPR036179 Immunoglobulin-like domain superfamilyFamilyHomologous superfamily

Diseases

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Drugs

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DrugNameSourceType
DB00098 Antithymocyte immunoglobulin (rabbit)Drugbankbiotech
DB06241 ClenoliximabDrugbankbiotech
DB12698 IbalizumabDrugbankbiotech

Interactions

51 interactions

InteractorPartnerSourcesPublicationsLink
CD4_HUMANLCK_HUMANBioGRID, HPRD, MINT11854499 12007789 15047060 16888650 17005671 17653867 8104794 8246987 details
CD4_HUMANSHIP2_HUMANBioGRID, IntAct21988832 details
CD4_HUMANMDR1_HUMANBioGRID, IntAct21988832 details
CD4_HUMANUBL7_HUMANBioGRID, IntAct21988832 details
CD4_HUMANCD4_HUMANBioGRID, DIP, HPRD12444132 15047060 9168119 details
CD4_HUMANLAMP2_HUMANIntAct32814053 details
CD4_HUMANSHLB1_HUMANIntAct32814053 details
CD4_HUMANU119A_HUMANBioGRID, HPRD14757743 details
CD4_HUMANPTPRC_HUMANBioGRID, HPRD1834739 details
CD4_HUMANSPG21_HUMANBioGRID, HPRD11113139 details
CD4_HUMANPIP_HUMANBioGRID, HPRD10820003 details
CD4_HUMANIL16_HUMANBioGRID, HPRD1851800 7910967 details
CD4_HUMANMK14_HUMANBioGRID20530479 details
CD4_HUMANADRB2_HUMANBioGRID24561123 details
CD4_HUMANSIVA_HUMANBioGRID17653867 details
CD4_HUMANAA2AR_HUMANBioGRID17356572 details
CD4_HUMANCCR5_HUMANBioGRID, DIP, HPRD, IntAct, UniProt10816381 15660419 30542158 details
CD4_HUMANGCR_HUMANBioGRID, MINT16888650 details
CD4_HUMANCXCR4_HUMANBioGRID, HPRD, UniProt10816381 14592831 15660419 details
CD4_HUMANCD81_HUMANBioGRID7636191 details
CD4_HUMANCD82_HUMANBioGRID, HPRD7636191 details
CD4_HUMANKSYK_HUMANBioGRID7539035 details
CD4_HUMANZAP70_HUMANBioGRID7539035 details
CD4_HUMANLEG1_HUMANBioGRID, HPRD10490978 details
CD4_HUMANEPS15_HUMANBioGRID16497223 details
CD4_HUMANCHIP_HUMANBioGRID20974815 details
CD4_HUMANHGS_HUMANBioGRID17686993 details
CD4_HUMANTERA_HUMANBioGRID22090097 details
CD4_HUMANRANB9_HUMANBioGRID14722085 details
CD4_HUMANCD44_HUMANHPRD7539755 details
CD4_HUMANCD38_HUMANHPRD7539755 details
CD4_HUMANP85A_HUMANHPRD8246987 details
CD4_HUMANCD28_HUMANHPRD7539755 details
CD4_HUMANCD2_HUMANHPRD7539755 details
CD4_HUMANDPP4_HUMANHPRD7539755 details
CD4_HUMANSDF1_HUMANHPRD10600606 details
CD4_HUMANLAT_HUMANHPRD10562325 details
CD4_HUMANLYAM1_HUMANHPRD7539755 details
CD4_HUMANPI4KA_HUMANHPRD8246987 details
CD4_HUMANDQA2_HUMANHPRD11535811 details
CD4_HUMANMARH4_HUMANHPRD14722266 details
CD4_HUMANCATD_HUMANHPRD11581410 details
CD4_HUMANTR10A_HUMANHPRD7650480 details
CD4_HUMANDQB1_HUMANHPRD11535811 details
CD4_HUMANKCAB2_HUMANHPRD12893943 details
CD4_HUMANTFR1_HUMANHPRD14705953 details
CD4_HUMANDPA1_HUMANHPRD12899833 details
CD4_HUMANFCG3A_HUMANHPRD11756173 details
CD4_HUMANIL2RA_HUMANHPRD7539755 details
CD4_HUMANCD53_HUMANHPRD7539755 details
CD4_HUMANCD5_HUMANHPRD7539755 details