Entity Details

Primary name GLCM_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionP04062
EntryNameGLCM_HUMAN
FullNameLysosomal acid glucosylceramidase
TaxID9606
Evidenceevidence at protein level
Length536
SequenceStatuscomplete
DateCreated1986-11-01
DateModified2021-06-02

Ontological Relatives

GenesGBA

GO terms

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GOName
GO:0004348 glucosylceramidase activity
GO:0005102 signaling receptor binding
GO:0005124 scavenger receptor binding
GO:0005764 lysosome
GO:0005765 lysosomal membrane
GO:0005783 endoplasmic reticulum
GO:0005794 Golgi apparatus
GO:0005802 trans-Golgi network
GO:0006680 glucosylceramide catabolic process
GO:0006687 glycosphingolipid metabolic process
GO:0006914 autophagy
GO:0007040 lysosome organization
GO:0008203 cholesterol metabolic process
GO:0008340 determination of adult lifespan
GO:0009267 cellular response to starvation
GO:0009268 response to pH
GO:0014004 microglia differentiation
GO:0016241 regulation of macroautophagy
GO:0019882 antigen processing and presentation
GO:0019898 extrinsic component of membrane
GO:0019915 lipid storage
GO:0021694 cerebellar Purkinje cell layer formation
GO:0021859 pyramidal neuron differentiation
GO:0023021 termination of signal transduction
GO:0030259 lipid glycosylation
GO:0031333 negative regulation of protein-containing complex assembly
GO:0032006 regulation of TOR signaling
GO:0032268 regulation of cellular protein metabolic process
GO:0032436 positive regulation of proteasomal ubiquitin-dependent protein catabolic process
GO:0032715 negative regulation of interleukin-6 production
GO:0033077 T cell differentiation in thymus
GO:0033561 regulation of water loss via skin
GO:0033574 response to testosterone
GO:0035307 positive regulation of protein dephosphorylation
GO:0043202 lysosomal lumen
GO:0043243 positive regulation of protein-containing complex disassembly
GO:0043407 negative regulation of MAP kinase activity
GO:0043524 negative regulation of neuron apoptotic process
GO:0043589 skin morphogenesis
GO:0043627 response to estrogen
GO:0046512 sphingosine biosynthetic process
GO:0046513 ceramide biosynthetic process
GO:0046527 glucosyltransferase activity
GO:0048469 cell maturation
GO:0048854 brain morphogenesis
GO:0048872 homeostasis of number of cells
GO:0050295 steryl-beta-glucosidase activity
GO:0050728 negative regulation of inflammatory response
GO:0050905 neuromuscular process
GO:0051247 positive regulation of protein metabolic process
GO:0051402 neuron apoptotic process
GO:0061518 microglial cell proliferation
GO:0061744 motor behavior
GO:0070062 extracellular exosome
GO:0071356 cellular response to tumor necrosis factor
GO:0071425 hematopoietic stem cell proliferation
GO:0071548 response to dexamethasone
GO:0072676 lymphocyte migration
GO:0097066 response to thyroid hormone
GO:1901215 negative regulation of neuron death
GO:1901805 beta-glucoside catabolic process
GO:1903052 positive regulation of proteolysis involved in cellular protein catabolic process
GO:1903061 positive regulation of protein lipidation
GO:1904457 positive regulation of neuronal action potential
GO:1904925 positive regulation of autophagy of mitochondrion in response to mitochondrial depolarization
GO:1905037 autophagosome organization
GO:1905165 regulation of lysosomal protein catabolic process

Subcellular Location

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Subcellular Location
Lysosome membrane

Domains

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DomainNameCategoryType
IPR001139 Glycoside hydrolase family 30FamilyFamily
IPR013780 Glycosyl hydrolase, all-betaFamilyHomologous superfamily
IPR017853 Glycoside hydrolase superfamilyFamilyHomologous superfamily
IPR033452 Glycosyl hydrolase family 30, beta sandwich domainDomainDomain
IPR033453 Glycosyl hydrolase family 30, TIM-barrel domainDomainDomain

Diseases

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Drugs

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DrugNameSourceType
DB03106 scyllo-inositolDrugbanksmall molecule
DB03740 N-acetyl-alpha-D-glucosamineDrugbanksmall molecule
DB06720 Velaglucerase alfaDrugbankbiotech
DB08283 (2R,3R,4R,5S)-2-(HYDROXYMETHYL)-1-NONYLPIPERIDINE-3,4,5-TRIOLDrugbanksmall molecule