Entity Details

Primary name ITB1_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionP05556
EntryNameITB1_HUMAN
FullNameIntegrin beta-1
TaxID9606
Evidenceevidence at protein level
Length798
SequenceStatuscomplete
DateCreated1988-11-01
DateModified2021-06-02

Ontological Relatives

GenesITGB1

GO terms

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GOName
GO:0000132 establishment of mitotic spindle orientation
GO:0001618 virus receptor activity
GO:0001726 ruffle
GO:0001968 fibronectin binding
GO:0002020 protease binding
GO:0003779 actin binding
GO:0005178 integrin binding
GO:0005737 cytoplasm
GO:0005886 plasma membrane
GO:0005925 focal adhesion
GO:0006909 phagocytosis
GO:0006968 cellular defense response
GO:0007155 cell adhesion
GO:0007156 homophilic cell adhesion via plasma membrane adhesion molecules
GO:0007159 leukocyte cell-cell adhesion
GO:0007160 cell-matrix adhesion
GO:0007161 calcium-independent cell-matrix adhesion
GO:0007229 integrin-mediated signaling pathway
GO:0009986 cell surface
GO:0010008 endosome membrane
GO:0010710 regulation of collagen catabolic process
GO:0010763 positive regulation of fibroblast migration
GO:0015026 coreceptor activity
GO:0016020 membrane
GO:0016477 cell migration
GO:0019058 viral life cycle
GO:0019221 cytokine-mediated signaling pathway
GO:0023035 CD40 signaling pathway
GO:0030027 lamellipodium
GO:0030030 cell projection organization
GO:0030032 lamellipodium assembly
GO:0030175 filopodium
GO:0030183 B cell differentiation
GO:0030198 extracellular matrix organization
GO:0030335 positive regulation of cell migration
GO:0031589 cell-substrate adhesion
GO:0031594 neuromuscular junction
GO:0031623 receptor internalization
GO:0032154 cleavage furrow
GO:0032587 ruffle membrane
GO:0033627 cell adhesion mediated by integrin
GO:0033631 cell-cell adhesion mediated by integrin
GO:0034113 heterotypic cell-cell adhesion
GO:0034665 integrin alpha1-beta1 complex
GO:0034666 integrin alpha2-beta1 complex
GO:0034667 integrin alpha3-beta1 complex
GO:0034668 integrin alpha4-beta1 complex
GO:0034674 integrin alpha5-beta1 complex
GO:0034678 integrin alpha8-beta1 complex
GO:0034680 integrin alpha10-beta1 complex
GO:0034681 integrin alpha11-beta1 complex
GO:0035633 maintenance of blood-brain barrier
GO:0042383 sarcolemma
GO:0042470 melanosome
GO:0043065 positive regulation of apoptotic process
GO:0043235 receptor complex
GO:0043547 positive regulation of GTPase activity
GO:0044877 protein-containing complex binding
GO:0045121 membrane raft
GO:0045296 cadherin binding
GO:0045766 positive regulation of angiogenesis
GO:0046718 viral entry into host cell
GO:0046872 metal ion binding
GO:0046982 protein heterodimerization activity
GO:0048333 mesodermal cell differentiation
GO:0050776 regulation of immune response
GO:0050839 cell adhesion molecule binding
GO:0050900 leukocyte migration
GO:0050901 leukocyte tethering or rolling
GO:0051897 positive regulation of protein kinase B signaling
GO:0051951 positive regulation of glutamate uptake involved in transmission of nerve impulse
GO:0055037 recycling endosome
GO:0070062 extracellular exosome
GO:0071404 cellular response to low-density lipoprotein particle stimulus
GO:0090303 positive regulation of wound healing
GO:0097386 glial cell projection
GO:0098639 collagen binding involved in cell-matrix adhesion
GO:0150003 regulation of spontaneous synaptic transmission
GO:0150103 reactive gliosis
GO:1901979 regulation of inward rectifier potassium channel activity
GO:1903078 positive regulation of protein localization to plasma membrane
GO:1990782 protein tyrosine kinase binding
GO:2000273 positive regulation of signaling receptor activity
GO:2000811 negative regulation of anoikis

Subcellular Location

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Subcellular Location
Cell junction
Cell membrane
Cell projection
Cell surface
Cleavage furrow
Melanosome
Recycling endosome

Domains

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DomainNameCategoryType
IPR002369 Integrin beta subunit, VWA domainDomainDomain
IPR012896 Integrin beta subunit, tailDomainDomain
IPR013111 EGF-like domain, extracellularDomainDomain
IPR014836 Integrin beta subunit, cytoplasmic domainDomainDomain
IPR015812 Integrin beta subunitFamilyFamily
IPR016201 PSI domainDomainDomain
IPR027071 Integrin beta-1 subunitFamilyFamily
IPR032695 Integrin domain superfamilyFamilyHomologous superfamily
IPR033760 Integrin beta N-terminalDomainDomain
IPR036349 Integrin beta tail domain superfamilyFamilyHomologous superfamily
IPR036465 von Willebrand factor A-like domain superfamilyFamilyHomologous superfamily
IPR040622 Integrin beta, epidermal growth factor-like domain 1DomainDomain

Diseases

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Drugs

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DrugNameSourceType
DB00098 Antithymocyte immunoglobulin (rabbit)Drugbankbiotech
DB15791 MK-0668Drugbanksmall molecule

Interactions

112 interactions

InteractorPartnerSourcesPublicationsLink
ITB1_HUMANFHL2_HUMANBioGRID, MINT10906324 details
ITB1_HUMAN1433B_HUMANBioGRID, MINT11313964 details
ITB1_HUMANTNS2_HUMANMINT12606711 details
ITB1_HUMANRBGP1_HUMANMINT12606711 details
ITB1_HUMANANS1B_HUMANMINT12606711 details
ITB1_HUMANFLNA_HUMANBioGRID, mbinfo, MINT10604475 11807098 15225631 17690686 18177638 9722563 details
ITB1_HUMANITB1_HUMANBioGRID, IntAct14681217 7681433 details
ITB1_HUMANITA2_HUMANBioGRID, IntAct, matrixdb10397731 14681217 21947080 details
ITB1_HUMANITA4_HUMANIntAct, mbinfo10604475 14681217 1542691 20159608 details
ITB1_HUMANPDIA3_HUMANBioGRID, MINT17170699 details
ITB1_HUMANITA5_HUMANBioGRID, DIP, IntAct, MINT12114318 12724312 12883474 16099422 20643357 21947080 22178926 22939629 25237190 26344197 30021884 7681433 details
ITB1_HUMANITBP1_HUMANBioGRID, IntAct11741908 11919189 28049720 9281591 details
ITB1_HUMANLYN_HUMANBioGRID, IntAct, mbinfo14593208 20159608 34079125 details
ITB1_HUMANIL3RB_HUMANI2D20802515 details
ITB1_HUMANANGL4_HUMANIntAct21397862 details
ITB1_HUMANODPB_HUMANBioGRID, IntAct21988832 details
ITB1_HUMANFINC_HUMANBioGRID, IntAct, MINT19738201 21985969 24789099 25237190 26456826 7681433 details
ITB1_HUMANPTN1_HUMANBioGRID, MINT21806020 32877691 details
ITB1_HUMANENOA_HUMANBioGRID, IntAct23414517 details
ITB1_HUMANLTOR5_HUMANBioGRID, IntAct23414517 details
ITB1_HUMANTLN1_HUMANBioGRID, mbinfo11279249 14691141 19843520 22939629 details
ITB1_HUMANADA17_HUMANIntAct, UniProt22413019 30455686 details
ITB1_HUMANX3CL1_HUMANIntAct24789099 details
ITB1_HUMANLEG8_HUMANBioGRID, IntAct10852818 26186194 28514442 details
ITB1_HUMANITAV_HUMANBioGRID, DIP16424009 22178926 25792870 26344197 details
ITB1_HUMANITA3_HUMANBioGRID, IntAct15254262 16878156 30021884 details
ITB1_HUMANJIP2_HUMANIntAct32814053 details
ITB1_HUMANTOM1_HUMANIntAct32814053 details
ITB1_HUMANP85A_HUMANBioGRID, IntAct15539082 32814053 details
ITB1_HUMANA4_HUMANIntAct32814053 details
ITB1_HUMANILK_HUMANBioGRID18339839 26172215 8538749 details
ITB1_HUMANFLNB_HUMANBioGRID11807098 details
ITB1_HUMANM4K4_HUMANBioGRID11967148 details
ITB1_HUMANACTN1_HUMANBioGRID2116421 details
ITB1_HUMANITA9_HUMANBioGRID18230652 28514442 8245132 details
ITB1_HUMANFBX2_HUMANBioGRID12140560 16275327 17116465 details
ITB1_HUMANNDKA_HUMANBioGRID11919189 details
ITB1_HUMANLAMA1_HUMANBioGRID9688542 details
ITB1_HUMANDAG1_HUMANBioGRID18341635 details
ITB1_HUMANTBA1A_HUMANBioGRID18341635 details
ITB1_HUMANRENT2_HUMANBioGRID15231747 details
ITB1_HUMANACAP1_HUMANBioGRID16256741 details
ITB1_HUMANOSTP_HUMANBioGRID7592829 details
ITB1_HUMANLG3BP_HUMANBioGRID24362527 details
ITB1_HUMANANGP2_HUMANBioGRID16424009 25237190 details
ITB1_HUMANEGFR_HUMANBioGRID23595626 31641961 details
ITB1_HUMANPI51C_HUMANBioGRID12782621 details
ITB1_HUMANDOK1_HUMANBioGRID19843520 details
ITB1_HUMANTIMP2_HUMANBioGRID12887919 details
ITB1_HUMANMET_HUMANBioGRID28973887 details
ITB1_HUMANFERM1_HUMANBioGRID25086068 details
ITB1_HUMANFERM2_HUMANBioGRID25086068 details
ITB1_HUMANURP2_HUMANBioGRID25086068 details
ITB1_HUMANNGF_HUMANBioGRID18230652 details
ITB1_HUMANC1QR1_HUMANBioGRID29763414 details
ITB1_HUMANEPS8_HUMANMINT12606711 details
ITB1_HUMANEMIL1_HUMANMINT12456677 details
ITB1_HUMANCD63_HUMANBioGRID, MINT12175627 16917503 24635319 details
ITB1_HUMANITA6_HUMANBioGRID, IntAct12883474 2649503 9660880 details
ITB1_HUMANRAB21_HUMANIntAct16754960 details
ITB1_HUMANRAB5A_HUMANBioGRID, IntAct16754960 34079125 details
ITB1_HUMANFABPH_HUMANI2D20802519 details
ITB1_HUMANSHRPN_HUMANIntAct21947080 details
ITB1_HUMANPAXI_HUMANBioGRID, mbinfo10604475 10804218 26992741 details
ITB1_HUMANCD9_HUMANBioGRID, MINT, UniProt12175627 23289620 26686862 30455686 8630057 details
ITB1_HUMANEGLN_HUMANMINT22940691 details
ITB1_HUMANCD81_HUMANBioGRID, IntAct10229664 12175627 30024968 32900848 details
ITB1_HUMANCRKL_HUMANDIP19168626 details
ITB1_HUMANCALX_HUMANBioGRID, IntAct29568061 8163531 details
ITB1_HUMANTGON2_HUMANBioGRID, IntAct11208159 29568061 details
ITB1_HUMANVGFR2_HUMANBioGRID, IntAct12114318 18931684 details
ITB1_HUMANIGF1R_HUMANIntAct15289498 details
ITB1_HUMANACE2_HUMANIntAct22523556 details
ITB1_HUMANACE_HUMANIntAct22523556 details
ITB1_HUMANRAB8B_HUMANBioGRID12639940 details
ITB1_HUMANCO1A1_HUMANBioGRID2156854 details
ITB1_HUMANITA8_HUMANBioGRID7768999 details
ITB1_HUMANMCP_HUMANBioGRID10741407 details
ITB1_HUMANRACK1_HUMANBioGRID12435334 9442085 details
ITB1_HUMANTSN4_HUMANBioGRID9360996 details
ITB1_HUMANVGFR3_HUMANBioGRID11553610 details
ITB1_HUMANCD151_HUMANBioGRID12175627 22495828 details
ITB1_HUMANKPCA_HUMANBioGRID12138200 12435334 details
ITB1_HUMANCD36_HUMANBioGRID11238109 details
ITB1_HUMANITA10_HUMANBioGRID9685391 details
ITB1_HUMAN4F2_HUMANBioGRID12181350 details
ITB1_HUMANTERA_HUMANBioGRID15723043 details
ITB1_HUMANMMP2_HUMANBioGRID22349830 details
ITB1_HUMANCD44_HUMANBioGRID21701559 details
ITB1_HUMANITA1_HUMANBioGRID12883474 7681433 details
ITB1_HUMANITA7_HUMANBioGRID11278916 details
ITB1_HUMANTSP1_HUMANBioGRID14963009 details
ITB1_HUMANEPHA2_HUMANBioGRID23874206 details
ITB1_HUMANRANB9_HUMANBioGRID14722085 details
ITB1_HUMANSE1L1_HUMANBioGRID24324549 details
ITB1_HUMANLEG3_HUMANBioGRID24755837 details
ITB1_HUMANFAK1_HUMANBioGRID19889638 25792870 26992741 details
ITB1_HUMANSHC1_HUMANBioGRID19889638 details
ITB1_HUMANERBB2_HUMANBioGRID12600989 details
ITB1_HUMANITB3_HUMANBioGRID25792870 details
ITB1_HUMANGGA3_HUMANBioGRID26935970 details
ITB1_HUMANSNX17_HUMANBioGRID26935970 details
ITB1_HUMANVHL_HUMANBioGRID18523483 details
ITB1_HUMANFAK2_HUMANBioGRID15539082 details
ITB1_HUMANCAH9_HUMANBioGRID28692057 details
ITB1_HUMANSL9A5_HUMANBioGRID16920332 details
ITB1_HUMANST7_HUMANBioGRID29395067 details
ITB1_HUMANTGM2_HUMANBioGRID11278623 details
ITB1_HUMANGGA2_HUMANBioGRID31076515 details
ITB1_HUMANRAB10_HUMANBioGRID31076515 details
ITB1_HUMANRAB13_HUMANBioGRID31076515 details
ITB1_HUMANSC23B_HUMANBioGRID31076515 details