Entity Details

Primary name PDIA1_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionP07237
EntryNamePDIA1_HUMAN
FullNameProtein disulfide-isomerase
TaxID9606
Evidenceevidence at protein level
Length508
SequenceStatuscomplete
DateCreated1988-04-01
DateModified2021-06-02

Ontological Relatives

GenesP4HB

GO terms

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GOName
GO:0003723 RNA binding
GO:0003756 protein disulfide isomerase activity
GO:0003779 actin binding
GO:0004656 procollagen-proline 4-dioxygenase activity
GO:0005178 integrin binding
GO:0005576 extracellular region
GO:0005783 endoplasmic reticulum
GO:0005788 endoplasmic reticulum lumen
GO:0005793 endoplasmic reticulum-Golgi intermediate compartment
GO:0005829 cytosol
GO:0005856 cytoskeleton
GO:0005925 focal adhesion
GO:0006457 protein folding
GO:0009897 external side of plasma membrane
GO:0016222 procollagen-proline 4-dioxygenase complex
GO:0016972 thiol oxidase activity
GO:0018401 peptidyl-proline hydroxylation to 4-hydroxy-L-proline
GO:0030027 lamellipodium
GO:0030199 collagen fibril organization
GO:0032991 protein-containing complex
GO:0034378 chylomicron assembly
GO:0034379 very-low-density lipoprotein particle assembly
GO:0034975 protein folding in endoplasmic reticulum
GO:0034976 response to endoplasmic reticulum stress
GO:0035722 interleukin-12-mediated signaling pathway
GO:0038155 interleukin-23-mediated signaling pathway
GO:0042470 melanosome
GO:0043687 post-translational protein modification
GO:0044267 cellular protein metabolic process
GO:0045785 positive regulation of cell adhesion
GO:0046598 positive regulation of viral entry into host cell
GO:0046982 protein heterodimerization activity
GO:0070062 extracellular exosome
GO:0071456 cellular response to hypoxia
GO:1900026 positive regulation of substrate adhesion-dependent cell spreading
GO:1902175 regulation of oxidative stress-induced intrinsic apoptotic signaling pathway

Subcellular Location

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Subcellular Location
Cell membrane
Endoplasmic reticulum
Endoplasmic reticulum lumen
Melanosome

Domains

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DomainNameCategoryType
IPR005788 Disulphide isomeraseDomainDomain
IPR005792 Protein disulphide isomeraseFamilyFamily
IPR013766 Thioredoxin domainDomainDomain
IPR017937 Thioredoxin, conserved siteSiteConserved site
IPR036249 Thioredoxin-like superfamilyFamilyHomologous superfamily

Diseases

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Drugs

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DrugNameSourceType
DB01593 ZincDrugbanksmall molecule
DB03615 RibostamycinDrugbanksmall molecule
DB09130 CopperDrugbanksmall molecule
DB11638 ArtenimolDrugbanksmall molecule
DB14487 Zinc acetateDrugbanksmall molecule
DB14533 Zinc chlorideDrugbanksmall molecule
DB14548 Zinc sulfate, unspecified formDrugbanksmall molecule

Interactions

95 interactions

InteractorPartnerSourcesPublicationsLink
PDIA1_HUMANPTN_HUMANBioGRID, HPRD, IntAct16169070 details
PDIA1_HUMANFEZ1_HUMANBioGRID, HPRD, IntAct16169070 details
PDIA1_HUMANPRDX4_HUMANMINT21057456 details
PDIA1_HUMANCSK22_HUMANBioGRID, IntAct21988832 details
PDIA1_HUMANENOA_HUMANBioGRID, IntAct23414517 26344197 details
PDIA1_HUMANTAU_HUMANIntAct24098548 details
PDIA1_HUMANKR411_HUMANBioGRID, IntAct32296183 details
PDIA1_HUMANLCE2D_HUMANBioGRID, IntAct32296183 details
PDIA1_HUMANGRN_HUMANBioGRID, IntAct, UniProt26370502 32296183 details
PDIA1_HUMANLRFN4_HUMANBioGRID, IntAct32296183 details
PDIA1_HUMANODFP1_HUMANBioGRID, IntAct32296183 details
PDIA1_HUMANCHCH2_HUMANBioGRID, IntAct32296183 details
PDIA1_HUMANCNNM3_HUMANBioGRID, IntAct32296183 details
PDIA1_HUMANZNF69_HUMANBioGRID, IntAct32296183 details
PDIA1_HUMANNECT2_HUMANBioGRID, IntAct32296183 details
PDIA1_HUMANKRA59_HUMANBioGRID, IntAct32296183 details
PDIA1_HUMANPLCX3_HUMANBioGRID, IntAct32296183 details
PDIA1_HUMANFA71C_HUMANBioGRID, IntAct32296183 details
PDIA1_HUMANTGFB1_HUMANBioGRID, IntAct32296183 details
PDIA1_HUMANKLH42_HUMANBioGRID, IntAct32296183 details
PDIA1_HUMANLCE1B_HUMANBioGRID, IntAct32296183 details
PDIA1_HUMANNOL4_HUMANBioGRID, IntAct32296183 details
PDIA1_HUMANKRA98_HUMANBioGRID, IntAct32296183 details
PDIA1_HUMANLCE4A_HUMANBioGRID, IntAct32296183 details
PDIA1_HUMANNGAL_HUMANBioGRID, IntAct32296183 details
PDIA1_HUMANNTRI_HUMANBioGRID, IntAct32296183 details
PDIA1_HUMANFZD10_HUMANBioGRID, IntAct32296183 details
PDIA1_HUMANCYTT_HUMANBioGRID, IntAct32296183 details
PDIA1_HUMANKR132_HUMANBioGRID, IntAct32296183 details
PDIA1_HUMANKR123_HUMANBioGRID, IntAct32296183 details
PDIA1_HUMANESR1_HUMANBioGRID, IntAct20348541 31527615 details
PDIA1_HUMANKLH36_HUMANIntAct32814053 details
PDIA1_HUMANFAKD1_HUMANIntAct32814053 details
PDIA1_HUMANANKE1_HUMANIntAct32814053 details
PDIA1_HUMANS22AH_HUMANIntAct32814053 details
PDIA1_HUMANSH3K1_HUMANIntAct32814053 details
PDIA1_HUMANPLK4_HUMANIntAct32814053 details
PDIA1_HUMANB2L11_HUMANIntAct32814053 details
PDIA1_HUMANSKAP1_HUMANIntAct32814053 details
PDIA1_HUMANRBBP4_HUMANIntAct32814053 details
PDIA1_HUMANPER1_HUMANIntAct32814053 details
PDIA1_HUMANK2C6A_HUMANIntAct32814053 details
PDIA1_HUMANGBB1_HUMANIntAct32814053 details
PDIA1_HUMANCAN2_HUMANIntAct32814053 details
PDIA1_HUMANBBS4_HUMANIntAct32814053 details
PDIA1_HUMANCP100_HUMANIntAct32814053 details
PDIA1_HUMANCCD26_HUMANIntAct32814053 details
PDIA1_HUMANDDT4L_HUMANIntAct32814053 details
PDIA1_HUMANTEX35_HUMANIntAct32814053 details
PDIA1_HUMANCEP76_HUMANIntAct32814053 details
PDIA1_HUMANUBQL1_HUMANBioGRID, HPRD12095988 details
PDIA1_HUMANTHYG_HUMANBioGRID, HPRD10636893 details
PDIA1_HUMANHNRPD_HUMANBioGRID15231747 details
PDIA1_HUMANPDIA1_HUMANBioGRID, HPRD12874193 24549644 25416956 details
PDIA1_HUMANLEG9_HUMANBioGRID21670307 details
PDIA1_HUMANITB3_HUMANBioGRID21670307 details
PDIA1_HUMANVWF_HUMANBioGRID26670633 details
PDIA1_HUMANSUMO2_HUMANBioGRID32786267 details
PDIA1_HUMANFA20C_HUMANBioGRID32149426 details
PDIA1_HUMANERN1_HUMANBioGRID32149426 details
PDIA1_HUMANOGT1_HUMANBioGRID32994395 details
PDIA1_HUMANCOAA1_HUMANHPRD, MINT10436013 details
PDIA1_HUMANERO1A_HUMANBioGRID, HPRD, MINT10970843 11707400 11847130 20802462 26344197 details
PDIA1_HUMANGBRL2_HUMANIntAct17353931 20562859 details
PDIA1_HUMANVHL_HUMANIntAct17353931 details
PDIA1_HUMANATG5_HUMANIntAct17353931 details
PDIA1_HUMANPAK2_HUMANIntAct17353931 details
PDIA1_HUMANTRM7_HUMANIntAct17353931 details
PDIA1_HUMAN1433Z_HUMANMINT15161933 details
PDIA1_HUMANTAP1_HUMANIntAct17055437 details
PDIA1_HUMANPDIA3_HUMANBioGRID, MINT17170699 19942855 26344197 details
PDIA1_HUMANHM13_HUMANMINT19942855 details
PDIA1_HUMANSODM_HUMANIntAct20195357 details
PDIA1_HUMANERO1B_HUMANBioGRID, HPRD, MINT11707400 11847130 20802462 details
PDIA1_HUMANPDIA2_HUMANMINT23167757 details
PDIA1_HUMANNEK7_HUMANBioGRID, IntAct27173435 unassigned1312 details
PDIA1_HUMANP4HA2_HUMANBioGRID, HPRD, IntAct26186194 26344197 27173435 30021884 7753822 unassigned1312 details
PDIA1_HUMANP4HA3_HUMANBioGRID, HPRD, IntAct12874193 14500733 28514442 details
PDIA1_HUMANTF_HUMANDIP16959886 details
PDIA1_HUMANPRIO_HUMANBioGRID, HPRD, UniProt15146195 29791485 details
PDIA1_HUMANCO1A1_HUMANHPRD, matrixdb1339453 26848503 details
PDIA1_HUMANHDAC5_HUMANBioGRID21081666 details
PDIA1_HUMANLMAN1_HUMANBioGRID22337587 26344197 details
PDIA1_HUMANCXCR4_HUMANBioGRID14592831 details
PDIA1_HUMANEGFR_HUMANBioGRID23956138 details
PDIA1_HUMANMTP_HUMANBioGRID23475612 details
PDIA1_HUMANU2AF2_HUMANBioGRID26641092 details
PDIA1_HUMANIAPP_HUMANBioGRID26607804 details
PDIA1_HUMANGPX7_HUMANBioGRID23919619 details
PDIA1_HUMANEDEM3_HUMANBioGRID29784879 details
PDIA1_HUMANFBLN3_HUMANBioGRID27777122 details
PDIA1_HUMANCD1D_HUMANHPRD11257307 details
PDIA1_HUMANCO1A2_HUMANHPRD10329688 details
PDIA1_HUMAN1433G_HUMANHPRD15324660 details
PDIA1_HUMANIF2A_HUMANHPRD1677563 details