Entity Details

Primary name TRY1_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionP07477
EntryNameTRY1_HUMAN
FullNameTrypsin-1
TaxID9606
Evidenceevidence at protein level
Length247
SequenceStatuscomplete
DateCreated1988-04-01
DateModified2021-06-02

Ontological Relatives

GenesPRSS1

GO terms

Show/Hide Table
GOName
GO:0004252 serine-type endopeptidase activity
GO:0005576 extracellular region
GO:0005615 extracellular space
GO:0006508 proteolysis
GO:0007586 digestion
GO:0009235 cobalamin metabolic process
GO:0022617 extracellular matrix disassembly
GO:0046872 metal ion binding
GO:0062023 collagen-containing extracellular matrix
GO:0072562 blood microparticle

Subcellular Location

Show/Hide Table
Subcellular Location
Secreted

Domains

Show/Hide Table
DomainNameCategoryType
IPR001254 Serine proteases, trypsin domainDomainDomain
IPR001314 Peptidase S1A, chymotrypsin familyFamilyFamily
IPR009003 Peptidase S1, PA clanFamilyHomologous superfamily
IPR018114 Serine proteases, trypsin family, histidine active siteSiteActive site
IPR033116 Serine proteases, trypsin family, serine active siteSiteActive site
IPR043504 Peptidase S1, PA clan, chymotrypsin-like foldFamilyHomologous superfamily

Diseases

Show/Hide Table

Drugs

Show/Hide Table
DrugNameSourceType
DB01665 2H-Benzimidazol-2-amineDrugbanksmall molecule
DB01705 Bis(5-Amidino-Benzimidazolyl)MethaneDrugbanksmall molecule
DB01725 2-{2-hydroxy-[1,1'-biphenyl]-3-yl}-1H-1,3-benzodiazole-5-carboximidamideDrugbanksmall molecule
DB01737 Nalpha-(2-Naphthylsulfonylglycyl)-3-Amidino-D,L-Phenylalanine-IsopropylesterDrugbanksmall molecule
DB01741 CRA_17693Drugbanksmall molecule
DB01745 N-Alpha-(2-Naphthylsulfonyl)-N(3-Amidino-L-Phenylalaninyl)Isopipecolinic Acid Methyl EsterDrugbanksmall molecule
DB01767 Hemi-BabimDrugbanksmall molecule
DB01771 CRA_10991Drugbanksmall molecule
DB01805 MonoisopropylphosphorylserineDrugbanksmall molecule
DB01836 [4-(6-Chloro-Naphthalene-2-Sulfonyl)-Piperazin-1-Yl]-(3,4,5,6-Tetrahydro-2h-[1,4']Bipyridinyl-4-Yl)-MethanoneDrugbanksmall molecule
DB01876 Bis(5-Amidino-2-Benzimidazolyl)MethanoneDrugbanksmall molecule
DB01905 2-(2-Hydroxy-5-Methoxy-Phenyl)-1h-Benzoimidazole-5-CarboxamidineDrugbanksmall molecule
DB01939 5-Amidino-BenzimidazoleDrugbanksmall molecule
DB02045 AmylamineDrugbanksmall molecule
DB02063 CRA_16847Drugbanksmall molecule
DB02081 Bis-BenzamidineDrugbanksmall molecule
DB02084 CRA_17312Drugbanksmall molecule
DB02112 Zk-806450Drugbanksmall molecule
DB02269 [4-({[5-Benzyloxy-1-(3-Carbamimidoyl-Benzyl)-1h-Indole-2-Carbonyl]-Amino}-Methyl)-Phenyl]-Trimethyl-AmmoniumDrugbanksmall molecule
DB02287 2-(2-hydroxy-phenyl)-3H-benzoimidazole-5-carboxamidineDrugbanksmall molecule
DB02288 CRA-9334Drugbanksmall molecule
DB02354 4-{[1-Methyl-5-(2-Methyl-Benzoimidazol-1-Ylmethyl)-1h-Benzoimidazol-2-Ylmethyl]-Amino}-BenzamidineDrugbanksmall molecule
DB02366 CRA_10762Drugbanksmall molecule
DB02435 AminomethylcyclohexaneDrugbanksmall molecule
DB02463 2-(2-Hydroxy-Phenyl)-1h-Indole-5-CarboxamidineDrugbanksmall molecule
DB02464 BenzylamineDrugbanksmall molecule
DB02526 CRA_10655Drugbanksmall molecule
DB02665 (1R,2S)-2-PhenylcyclopropanaminiumDrugbanksmall molecule
DB02744 RPR131247Drugbanksmall molecule
DB02812 RWJ-56423Drugbanksmall molecule
DB02875 CRA_1802Drugbanksmall molecule
DB02989 CRA_10972Drugbanksmall molecule
DB03016 CRA_1801Drugbanksmall molecule
DB03081 [N-[N-(4-Methoxy-2,3,6-trimethylphenylsulfonyl)-L-aspartyl]-D-(4-amidino-phenylalanyl)]-piperidineDrugbanksmall molecule
DB03127 BenzamidineDrugbanksmall molecule
DB03136 4-Iodobenzo[B]Thiophene-2-CarboxamidineDrugbanksmall molecule
DB03159 CRA_8696Drugbanksmall molecule
DB03173 CRA_10433Drugbanksmall molecule
DB03213 Bis(5-Amidino-2-Benzimidazolyl)Methane KetoneDrugbanksmall molecule
DB03243 4-FluorobenzylamineDrugbanksmall molecule
DB03251 RWJ-51084Drugbanksmall molecule
DB03337 1-(2-Amidinophenyl)-3-(Phenoxyphenyl)UreaDrugbanksmall molecule
DB03373 ZK-806711Drugbanksmall molecule
DB03374 3,5-DiiodotyrosineDrugbanksmall molecule
DB03417 (2S,3R)-2-[[4-(Tert-butylcarbamoyl)piperazine-1-carbonyl]amino]-6-(diaminomethylideneamino)-3-formylhexanoic acidDrugbanksmall molecule
DB03443 bis(5-amidino-benzimidazolyl)methanone zincDrugbanksmall molecule
DB03555 CRA_11092Drugbanksmall molecule
DB03595 CRA_9785Drugbanksmall molecule
DB03608 DiminazeneDrugbanksmall molecule
DB03643 CRA_1144Drugbanksmall molecule
DB03865 6-Chloro-2-(2-Hydroxy-Biphenyl-3-Yl)-1h-Indole-5-CarboxamidineDrugbanksmall molecule
DB03876 Thieno[2,3-B]Pyridine-2-CarboxamidineDrugbanksmall molecule
DB03976 PhosphorylisopropaneDrugbanksmall molecule
DB04008 Zinc;[amino-[2-[[5-[amino(azaniumylidene)methyl]benzimidazol-1-id-2-yl]methyl]benzimidazol-1-id-5-yl]methylidene]azaniumDrugbanksmall molecule
DB04107 [(1-{2[(4-Carbamimidoyl-Phenylamino)-Methyl]-1-Methyl-1h-Benzoimidazol-5-Yl}-Cyclopropyl)-Pyridin-2-Yl-Methyleneaminooxy]-Acetic Acid Ethyl EsterDrugbanksmall molecule
DB04125 N-Alpha-(2-Naphthylsulfonyl)-N(3-Amidino-L-Phenylalaninyl)-4-Acetyl-PiperazineDrugbanksmall molecule
DB04215 CRA_9076Drugbanksmall molecule
DB04238 N-Alpha-(2-Naphthylsulfonyl)-N-(3-Amidino-L-Phenylalaninyl)-D-Pipecolinic AcidDrugbanksmall molecule
DB04246 CRA_23653Drugbanksmall molecule
DB04269 Cyclotheonamide ADrugbanksmall molecule
DB04301 Bis(5-Amidino-2-Benzimidazolyl)Methane Ketone HydrateDrugbanksmall molecule
DB04311 4-PhenylbutylamineDrugbanksmall molecule
DB04325 PhenethylamineDrugbanksmall molecule
DB04336 1-(4-Amidinophenyl)-3-(4-Chlorophenyl)UreaDrugbanksmall molecule
DB04391 Aeruginosin 98-BDrugbanksmall molecule
DB04410 3-PhenylpropylamineDrugbanksmall molecule
DB04424 RPR128515Drugbanksmall molecule
DB04432 ZK-805623Drugbanksmall molecule
DB04442 Imino[2-(2-oxo-1,2-dihydro-3-pyridinyl)-1H-benzimidazol-5-yl]methanaminiumDrugbanksmall molecule
DB04446 Benzo[B]Thiophene-2-CarboxamidineDrugbanksmall molecule
DB04470 CRA_10656Drugbanksmall molecule
DB04563 CRA_9678Drugbanksmall molecule
DB04654 4-PIPERIDIN-4-YLBUTANALDrugbanksmall molecule
DB04790 2,5-bis-O-{3-[amino(imino)methyl]phenyl}-1,4:3,6-dianhydro-D-glucitolDrugbanksmall molecule
DB04791 2-O-(4'-AMIDINOPHENYL)-5-O-(3''-AMIDINOPHENYL)-1,4:3,6-DIANHYDRO-D-SORBITOLDrugbanksmall molecule
DB04792 2,5-O,O-BIS-{4',4''-AMIDINOPHENYL}-1,4:3,6-DIANHYDRO-D-SORBITOLDrugbanksmall molecule
DB04793 1,4:3,6-Dianhydro-2-O-(3-carbamimidoylphenyl)-5-O-(4-carbamimidoylphenyl)-D-glucitolDrugbanksmall molecule
DB06692 AprotininDrugbankbiotech
DB06840 diethyl [(1R)-1,5-diaminopentyl]boronateDrugbanksmall molecule
DB06845 (S)-N-(4-carbamimidoylbenzyl)-1-(2-(cyclopentylamino)ethanoyl)pyrrolidine-2-carboxamideDrugbanksmall molecule
DB06850 (S)-N-(4-carbamimidoylbenzyl)-1-(2-(cyclohexylamino)ethanoyl)pyrrolidine-2-carboxamideDrugbanksmall molecule
DB06853 N-cycloheptylglycyl-N-(4-carbamimidoylbenzyl)-L-prolinamideDrugbanksmall molecule
DB06855 6-fluoro-2-(2-hydroxy-3-isobutoxy-phenyl)-1H-benzoimidazole-5-carboxamidineDrugbanksmall molecule
DB06858 N-cyclooctylglycyl-N-(4-carbamimidoylbenzyl)-L-prolinamideDrugbanksmall molecule
DB06918 2-(2-METHYLPHENYL)-1H-INDOLE-6-CARBOXIMIDAMIDEDrugbanksmall molecule
DB06923 2-(3-METHYLPHENYL)-1H-INDOLE-5-CARBOXIMIDAMIDEDrugbanksmall molecule
DB07088 (S)-N-(4-carbamimidoylbenzyl)-1-(2-(cyclopentyloxy)ethanoyl)pyrrolidine-2-carboxamideDrugbanksmall molecule
DB07091 (S)-N-(4-carbamimidoylbenzyl)-1-(2-(cyclohexyloxy)ethanoyl)pyrrolidine-2-carboxamideDrugbanksmall molecule
DB07095 (S)-N-(4-carbamimidoylbenzyl)-1-(3-cyclopentylpropanoyl)pyrrolidine-2-carboxamideDrugbanksmall molecule
DB07131 (S)-N-(4-carbamimidoylbenzyl)-1-(3-cyclohexylpropanoyl)pyrrolidine-2-carboxamideDrugbanksmall molecule
DB07229 3-{5-[AMINO(IMINIO)METHYL]-1H-INDOL-2-YL}-5-METHOXY-1,1'-BIPHENYL-2-OLATEDrugbanksmall molecule
DB07368 4-(METHYLSULFONYL)BENZENECARBOXIMIDAMIDEDrugbanksmall molecule
DB07491 5-amino-2,4,6-tribromobenzene-1,3-dicarboxylic acidDrugbanksmall molecule
DB07985 +/-METHYL 4-(AMINOIMINOMETHYL)-BETA-[3- INH (AMINOIMINO)PHENYL]BENZENE PENTANOATEDrugbanksmall molecule
DB08184 2-(2-METHYLPHENYL)-1H-INDOLE-5-CARBOXIMIDAMIDEDrugbanksmall molecule
DB08254 2-Naphthalenesulfonic acidDrugbanksmall molecule
DB08420 1-{[1-(2-AMINO-3-PHENYL-PROPIONYL)-PYRROLIDINE-2-CARBONYL]-AMINO}-2-(3-CYANO-PHENYL)-ETHANEBORONIC ACIDDrugbanksmall molecule
DB08763 [N-(BENZYLOXYCARBONYL)AMINO](4-AMIDINOPHENYL)METHANE-PHOSPHONATEDrugbanksmall molecule
DB12598 NafamostatDrugbanksmall molecule
DB12831 GabexateDrugbanksmall molecule
DB13729 CamostatDrugbanksmall molecule