Entity Details

Primary name FUMH_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionP07954
EntryNameFUMH_HUMAN
FullNameFumarate hydratase, mitochondrial
TaxID9606
Evidenceevidence at protein level
Length510
SequenceStatuscomplete
DateCreated1988-08-01
DateModified2021-06-02

Ontological Relatives

GenesFH

GO terms

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GOName
GO:0000050 urea cycle
GO:0000415 negative regulation of histone H3-K36 methylation
GO:0000821 regulation of arginine metabolic process
GO:0004333 fumarate hydratase activity
GO:0005634 nucleus
GO:0005694 chromosome
GO:0005737 cytoplasm
GO:0005739 mitochondrion
GO:0005759 mitochondrial matrix
GO:0005829 cytosol
GO:0006099 tricarboxylic acid cycle
GO:0006106 fumarate metabolic process
GO:0006108 malate metabolic process
GO:0006281 DNA repair
GO:0006974 cellular response to DNA damage stimulus
GO:0035861 site of double-strand break
GO:0042393 histone binding
GO:0045239 tricarboxylic acid cycle enzyme complex
GO:0048873 homeostasis of number of cells within a tissue
GO:0070062 extracellular exosome
GO:0120162 positive regulation of cold-induced thermogenesis
GO:2001034 positive regulation of double-strand break repair via nonhomologous end joining

Subcellular Location

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Subcellular Location
Chromosome
Cytoplasm
Mitochondrion
Nucleus

Domains

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DomainNameCategoryType
IPR000362 Fumarate lyase familyFamilyFamily
IPR005677 Fumarate hydratase, class IIFamilyFamily
IPR008948 L-Aspartase-likeFamilyHomologous superfamily
IPR018951 Fumarase C, C-terminalDomainDomain
IPR020557 Fumarate lyase, conserved siteSiteConserved site
IPR022761 Fumarate lyase, N-terminalDomainDomain
IPR024083 Fumarase/histidase, N-terminalFamilyHomologous superfamily

Diseases

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