Entity Details

Primary name ACM4_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionP08173
EntryNameACM4_HUMAN
FullNameMuscarinic acetylcholine receptor M4
TaxID9606
Evidenceevidence at protein level
Length479
SequenceStatuscomplete
DateCreated1988-08-01
DateModified2021-06-02

Ontological Relatives

GenesCHRM4

GO terms

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GOName
GO:0004993 G protein-coupled serotonin receptor activity
GO:0005886 plasma membrane
GO:0005887 integral component of plasma membrane
GO:0007165 signal transduction
GO:0007166 cell surface receptor signaling pathway
GO:0007186 G protein-coupled receptor signaling pathway
GO:0007187 G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger
GO:0007197 adenylate cyclase-inhibiting G protein-coupled acetylcholine receptor signaling pathway
GO:0007213 G protein-coupled acetylcholine receptor signaling pathway
GO:0007268 chemical synaptic transmission
GO:0016907 G protein-coupled acetylcholine receptor activity
GO:0030425 dendrite
GO:0030594 neurotransmitter receptor activity
GO:0040012 regulation of locomotion
GO:0045202 synapse
GO:0045211 postsynaptic membrane

Subcellular Location

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Subcellular Location
Cell junction
Cell membrane

Domains

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DomainNameCategoryType
IPR000276 G protein-coupled receptor, rhodopsin-likeFamilyFamily
IPR000995 Muscarinic acetylcholine receptor familyFamilyFamily
IPR001432 Muscarinic acetylcholine receptor M4FamilyFamily
IPR017452 GPCR, rhodopsin-like, 7TMDomainDomain

Diseases

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Drugs

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DrugNameSourceType
DB00246 ZiprasidoneDrugbanksmall molecule
DB00321 AmitriptylineDrugbanksmall molecule
DB00334 OlanzapineDrugbanksmall molecule
DB00340 MetixeneDrugbanksmall molecule
DB00342 TerfenadineDrugbanksmall molecule
DB00363 ClozapineDrugbanksmall molecule
DB00366 DoxylamineDrugbanksmall molecule
DB00376 TrihexyphenidylDrugbanksmall molecule
DB00387 ProcyclidineDrugbanksmall molecule
DB00408 LoxapineDrugbanksmall molecule
DB00411 CarbamoylcholineDrugbanksmall molecule
DB00424 HyoscyamineDrugbanksmall molecule
DB00454 MeperidineDrugbanksmall molecule
DB00458 ImipramineDrugbanksmall molecule
DB00496 DarifenacinDrugbanksmall molecule
DB00540 NortriptylineDrugbanksmall molecule
DB00543 AmoxapineDrugbanksmall molecule
DB00568 CinnarizineDrugbanksmall molecule
DB00572 AtropineDrugbanksmall molecule
DB00622 NicardipineDrugbanksmall molecule
DB00715 ParoxetineDrugbanksmall molecule
DB00725 Homatropine methylbromideDrugbanksmall molecule
DB00726 TrimipramineDrugbanksmall molecule
DB00747 ScopolamineDrugbanksmall molecule
DB00767 BenzquinamideDrugbanksmall molecule
DB00777 PropiomazineDrugbanksmall molecule
DB00809 TropicamideDrugbanksmall molecule
DB00835 BrompheniramineDrugbanksmall molecule
DB00934 MaprotilineDrugbanksmall molecule
DB00940 MethanthelineDrugbanksmall molecule
DB01019 BethanecholDrugbanksmall molecule
DB01036 TolterodineDrugbanksmall molecule
DB01069 PromethazineDrugbanksmall molecule
DB01085 PilocarpineDrugbanksmall molecule
DB01142 DoxepinDrugbanksmall molecule
DB01151 DesipramineDrugbanksmall molecule
DB01221 KetamineDrugbanksmall molecule
DB01224 QuetiapineDrugbanksmall molecule
DB01238 AripiprazoleDrugbanksmall molecule
DB01239 ChlorprothixeneDrugbanksmall molecule
DB01403 MethotrimeprazineDrugbanksmall molecule
DB01409 TiotropiumDrugbanksmall molecule
DB01591 SolifenacinDrugbanksmall molecule
DB01625 IsopropamideDrugbanksmall molecule
DB03128 AcetylcholineDrugbanksmall molecule
DB05752 ALKS 27Drugbanksmall molecule
DB06702 FesoterodineDrugbanksmall molecule
DB06787 HexocycliumDrugbanksmall molecule
DB08897 AclidiniumDrugbanksmall molecule
DB09076 UmeclidiniumDrugbanksmall molecule
DB09089 TrimebutineDrugbanksmall molecule
DB09167 DosulepinDrugbanksmall molecule
DB09194 EtoperidoneDrugbanksmall molecule
DB11181 HomatropineDrugbanksmall molecule
DB11235 ThonzylamineDrugbanksmall molecule
DB11855 RevefenacinDrugbanksmall molecule
DB12278 PropiverineDrugbanksmall molecule
DB13581 RociverineDrugbanksmall molecule
DB14185 Aripiprazole lauroxilDrugbanksmall molecule