Entity Details

Primary name ITA5_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionP08648
EntryNameITA5_HUMAN
FullNameIntegrin alpha-5
TaxID9606
Evidenceevidence at protein level
Length1049
SequenceStatuscomplete
DateCreated1988-08-01
DateModified2021-06-02

Ontological Relatives

GenesITGA5

GO terms

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GOName
GO:0001525 angiogenesis
GO:0001618 virus receptor activity
GO:0001726 ruffle
GO:0005154 epidermal growth factor receptor binding
GO:0005161 platelet-derived growth factor receptor binding
GO:0005178 integrin binding
GO:0005783 endoplasmic reticulum
GO:0005794 Golgi apparatus
GO:0005886 plasma membrane
GO:0005925 focal adhesion
GO:0007044 cell-substrate junction assembly
GO:0007155 cell adhesion
GO:0007157 heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules
GO:0007159 leukocyte cell-cell adhesion
GO:0007229 integrin-mediated signaling pathway
GO:0007565 female pregnancy
GO:0007613 memory
GO:0008305 integrin complex
GO:0009897 external side of plasma membrane
GO:0009986 cell surface
GO:0010811 positive regulation of cell-substrate adhesion
GO:0023035 CD40 signaling pathway
GO:0030198 extracellular matrix organization
GO:0030335 positive regulation of cell migration
GO:0030949 positive regulation of vascular endothelial growth factor receptor signaling pathway
GO:0031410 cytoplasmic vesicle
GO:0031589 cell-substrate adhesion
GO:0033627 cell adhesion mediated by integrin
GO:0033631 cell-cell adhesion mediated by integrin
GO:0034113 heterotypic cell-cell adhesion
GO:0034674 integrin alpha5-beta1 complex
GO:0035313 wound healing, spreading of epidermal cells
GO:0035987 endodermal cell differentiation
GO:0043184 vascular endothelial growth factor receptor 2 binding
GO:0045202 synapse
GO:0046872 metal ion binding
GO:0050731 positive regulation of peptidyl-tyrosine phosphorylation
GO:0050900 leukocyte migration
GO:0071062 alphav-beta3 integrin-vitronectin complex
GO:1903672 positive regulation of sprouting angiogenesis
GO:2000811 negative regulation of anoikis

Subcellular Location

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Subcellular Location
Cell junction
Cell surface
Membrane

Domains

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DomainNameCategoryType
IPR000413 Integrin alpha chainFamilyFamily
IPR013517 FG-GAP repeatRepeatRepeat
IPR013519 Integrin alpha beta-propellorRepeatRepeat
IPR013649 Integrin alpha-2DomainDomain
IPR018184 Integrin alpha chain, C-terminal cytoplasmic region, conserved siteSiteConserved site
IPR028994 Integrin alpha, N-terminalFamilyHomologous superfamily
IPR032695 Integrin domain superfamilyFamilyHomologous superfamily

Diseases

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Drugs

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DrugNameSourceType
DB02709 ResveratrolDrugbanksmall molecule

Interactions

48 interactions

InteractorPartnerSourcesPublicationsLink
ITA5_HUMANFINC_HUMANBioGRID, HPRD, IntAct, MINT11801679 1532572 16457822 1694173 19738201 20643357 24789099 25237190 26456826 7681433 9211865 details
ITA5_HUMANITB1_HUMANBioGRID, DIP, IntAct, MINT12114318 12724312 12883474 16099422 20643357 21947080 22178926 22939629 25237190 26344197 30021884 7681433 details
ITA5_HUMANGRK6_HUMANBioGRID, IntAct21988832 details
ITA5_HUMANSTABP_HUMANBioGRID, IntAct21988832 details
ITA5_HUMANSHRPN_HUMANBioGRID, IntAct21947080 26600301 details
ITA5_HUMANGP182_HUMANBioGRID, MINT28298427 details
ITA5_HUMANAUP1_HUMANBioGRID12042322 details
ITA5_HUMANGIPC1_HUMANBioGRID, HPRD11479315 11852236 details
ITA5_HUMANL1CAM_HUMANBioGRID, HPRD10871287 details
ITA5_HUMANMSS4_HUMANBioGRID10094488 details
ITA5_HUMANITB3_HUMANBioGRID, HPRD10358085 1694173 22470492 26344197 details
ITA5_HUMANLG3BP_HUMANBioGRID24362527 details
ITA5_HUMANCLK1_HUMANBioGRID26167880 details
ITA5_HUMANUBAP1_HUMANBioGRID26456826 details
ITA5_HUMANANGP2_HUMANBioGRID16424009 25237190 details
ITA5_HUMANTIMP2_HUMANBioGRID12887919 details
ITA5_HUMANVINC_HUMANBioGRID18056416 details
ITA5_HUMANCCN2_HUMANMINT16457822 details
ITA5_HUMANFABPH_HUMANI2D20802519 details
ITA5_HUMANEGLN_HUMANMINT22940691 details
ITA5_HUMANTGFR1_HUMANMINT22940691 details
ITA5_HUMANACVL1_HUMANMINT22940691 details
ITA5_HUMANNRP1_HUMANDIP19175293 details
ITA5_HUMANCD9_HUMANBioGRID, HPRD, UniProt10065872 26686862 details
ITA5_HUMANILK_HUMANBioGRID8538749 details
ITA5_HUMANFGFR2_HUMANBioGRID15728256 details
ITA5_HUMANCBL_HUMANBioGRID15728256 details
ITA5_HUMANUBC_HUMANBioGRID15728256 details
ITA5_HUMANSE1L1_HUMANBioGRID24324549 details
ITA5_HUMANITB5_HUMANBioGRID, HPRD11462216 22470492 7592829 details
ITA5_HUMANCIB1_HUMANBioGRID24163826 details
ITA5_HUMANTLN1_HUMANBioGRID28263956 details
ITA5_HUMANVHL_HUMANBioGRID18523483 details
ITA5_HUMANVGFR2_HUMANBioGRID12114318 details
ITA5_HUMANST7_HUMANBioGRID29395067 details
ITA5_HUMANIBP2_HUMANBioGRID20514406 details
ITA5_HUMANEGFR_HUMANBioGRID, HPRD10888683 31641961 details
ITA5_HUMANERBB2_HUMANHPRD15757908 details
ITA5_HUMANVGFR3_HUMANHPRD15389531 details
ITA5_HUMANANGP1_HUMANHPRD15781448 details
ITA5_HUMANCO1A1_HUMANHPRD1693626 details
ITA5_HUMANCOIA1_HUMANHPRD11158588 details
ITA5_HUMANOSTP_HUMANHPRD7592829 details
ITA5_HUMANPECA1_HUMANHPRD10982404 details
ITA5_HUMANTENA_HUMANHPRD9314546 details
ITA5_HUMANRHG05_HUMANHPRD8537347 details
ITA5_HUMANANGL3_HUMANHPRD11877390 details
ITA5_HUMANNISCH_HUMANHPRD12868002 15028619 details