Entity Details

Primary name DOPO_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionP09172
EntryNameDOPO_HUMAN
FullNameDopamine beta-hydroxylase
TaxID9606
Evidenceevidence at protein level
Length617
SequenceStatuscomplete
DateCreated1989-07-01
DateModified2021-06-02

Ontological Relatives

GenesDBH

GO terms

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GOName
GO:0001974 blood vessel remodeling
GO:0001975 response to amphetamine
GO:0002443 leukocyte mediated immunity
GO:0003824 catalytic activity
GO:0004500 dopamine beta-monooxygenase activity
GO:0005507 copper ion binding
GO:0005576 extracellular region
GO:0005615 extracellular space
GO:0005737 cytoplasm
GO:0005783 endoplasmic reticulum
GO:0006589 octopamine biosynthetic process
GO:0007268 chemical synaptic transmission
GO:0007613 memory
GO:0007626 locomotory behavior
GO:0008542 visual learning
GO:0016020 membrane
GO:0016021 integral component of membrane
GO:0030658 transport vesicle membrane
GO:0030667 secretory granule membrane
GO:0031418 L-ascorbic acid binding
GO:0034451 centriolar satellite
GO:0034466 chromaffin granule lumen
GO:0034774 secretory granule lumen
GO:0042127 regulation of cell population proliferation
GO:0042309 homoiothermy
GO:0042420 dopamine catabolic process
GO:0042421 norepinephrine biosynthetic process
GO:0042423 catecholamine biosynthetic process
GO:0042584 chromaffin granule membrane
GO:0042593 glucose homeostasis
GO:0042596 fear response
GO:0042711 maternal behavior
GO:0043231 intracellular membrane-bounded organelle
GO:0045202 synapse
GO:0045907 positive regulation of vasoconstriction
GO:0048149 behavioral response to ethanol
GO:0048265 response to pain
GO:0050900 leukocyte migration
GO:0120162 positive regulation of cold-induced thermogenesis
GO:2001236 regulation of extrinsic apoptotic signaling pathway

Subcellular Location

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Subcellular Location
Cytoplasmic vesicle
Secreted

Domains

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DomainNameCategoryType
IPR000323 Copper type II, ascorbate-dependent monooxygenase, N-terminalDomainDomain
IPR000945 Dopamine beta-hydroxylase-likeFamilyFamily
IPR005018 DOMON domainDomainDomain
IPR008977 PHM/PNGase F domain superfamilyFamilyHomologous superfamily
IPR014783 Copper type II, ascorbate-dependent monooxygenase, histidine-cluster-2 conserved siteSiteConserved site
IPR014784 Copper type II, ascorbate-dependent monooxygenase-like, C-terminalFamilyHomologous superfamily
IPR020611 Copper type II, ascorbate-dependent monooxygenase, histidine-cluster-1 conserved siteSiteConserved site
IPR024548 Copper type II ascorbate-dependent monooxygenase, C-terminalDomainDomain
IPR028460 Tyramine beta-hydroxylase/Dopamine beta-hydroxylaseFamilyFamily
IPR036939 Copper type II, ascorbate-dependent monooxygenase, N-terminal domain superfamilyFamilyHomologous superfamily

Diseases

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Drugs

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DrugNameSourceType
DB00126 Ascorbic acidDrugbanksmall molecule
DB00550 PropylthiouracilDrugbanksmall molecule
DB00822 DisulfiramDrugbanksmall molecule
DB00988 DopamineDrugbanksmall molecule
DB05394 CorticorelinSwissprotsmall molecule
DB06774 CapsaicinDrugbanksmall molecule
DB09130 CopperDrugbanksmall molecule