Entity Details

Primary name SPRC_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionP09486
EntryNameSPRC_HUMAN
FullNameSPARC
TaxID9606
Evidenceevidence at protein level
Length303
SequenceStatuscomplete
DateCreated1989-07-01
DateModified2021-06-02

Ontological Relatives

GenesSPARC

GO terms

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GOName
GO:0001503 ossification
GO:0001937 negative regulation of endothelial cell proliferation
GO:0002576 platelet degranulation
GO:0005509 calcium ion binding
GO:0005518 collagen binding
GO:0005576 extracellular region
GO:0005604 basement membrane
GO:0005615 extracellular space
GO:0005737 cytoplasm
GO:0005886 plasma membrane
GO:0006898 receptor-mediated endocytosis
GO:0007507 heart development
GO:0009629 response to gravity
GO:0009986 cell surface
GO:0010288 response to lead ion
GO:0010595 positive regulation of endothelial cell migration
GO:0016363 nuclear matrix
GO:0016525 negative regulation of angiogenesis
GO:0022604 regulation of cell morphogenesis
GO:0030198 extracellular matrix organization
GO:0030324 lung development
GO:0031091 platelet alpha granule
GO:0031092 platelet alpha granule membrane
GO:0031093 platelet alpha granule lumen
GO:0032496 response to lipopolysaccharide
GO:0033591 response to L-ascorbic acid
GO:0034097 response to cytokine
GO:0042060 wound healing
GO:0043231 intracellular membrane-bounded organelle
GO:0043434 response to peptide hormone
GO:0045471 response to ethanol
GO:0046686 response to cadmium ion
GO:0048839 inner ear development
GO:0048856 anatomical structure development
GO:0050807 regulation of synapse organization
GO:0050840 extracellular matrix binding
GO:0051384 response to glucocorticoid
GO:0051591 response to cAMP
GO:0051592 response to calcium ion
GO:0062023 collagen-containing extracellular matrix
GO:0071682 endocytic vesicle lumen
GO:0098978 glutamatergic synapse

Subcellular Location

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Subcellular Location
Secreted

Domains

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DomainNameCategoryType
IPR001999 Osteonectin-like, conserved siteSiteConserved site
IPR002350 Kazal domainDomainDomain
IPR003645 Follistatin-like, N-terminalDomainDomain
IPR011992 EF-hand domain pairFamilyHomologous superfamily
IPR015369 Follistatin/Osteonectin EGF domainDomainDomain
IPR018247 EF-Hand 1, calcium-binding siteSiteBinding site
IPR019577 SPARC/Testican, calcium-binding domainDomainDomain
IPR036058 Kazal domain superfamilyFamilyHomologous superfamily
IPR037641 SPARCFamilyFamily

Diseases

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Drugs

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DrugNameSourceType
DB11093 Calcium citrateDrugbanksmall molecule
DB11348 Calcium PhosphateDrugbanksmall molecule
DB14481 Calcium phosphate dihydrateDrugbanksmall molecule