Entity Details

Primary name LPH_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionP09848
EntryNameLPH_HUMAN
FullNameLactase-phlorizin hydrolase
TaxID9606
Evidenceevidence at transcript level
Length1927
SequenceStatuscomplete
DateCreated1989-07-01
DateModified2021-06-02

Ontological Relatives

GenesLCT

GO terms

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GOName
GO:0000016 lactase activity
GO:0005783 endoplasmic reticulum
GO:0005886 plasma membrane
GO:0005887 integral component of plasma membrane
GO:0005975 carbohydrate metabolic process
GO:0008422 beta-glucosidase activity
GO:0016020 membrane
GO:0016324 apical plasma membrane
GO:0017042 glycosylceramidase activity
GO:0044245 polysaccharide digestion

Subcellular Location

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Subcellular Location
Apical cell membrane

Domains

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DomainNameCategoryType
IPR001360 Glycoside hydrolase family 1FamilyFamily
IPR017853 Glycoside hydrolase superfamilyFamilyHomologous superfamily
IPR018120 Glycoside hydrolase family 1, active siteSiteActive site
IPR033132 Glycosyl hydrolases family 1, N-terminal conserved siteSiteConserved site

Diseases

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Drugs

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DrugNameSourceType
DB02376 D-gluconhydroximo-1,5-lactamDrugbanksmall molecule
DB02471 Nojirimycine TetrazoleDrugbanksmall molecule
DB03389 alpha-D-XylopyranoseDrugbanksmall molecule
DB04282 2-deoxy-2-fluoro-a-D-glucoseDrugbanksmall molecule
DB04564 GluconolactoneDrugbanksmall molecule
DB04659 (1S,2S,3R,4S,5S)-2,3,4-TRIHYDROXY-5-(HYDROXYMETHYL)CYCLOHEXYL (1E)-2-PHENYL-N-(SULFOOXY)ETHANIMIDOTHIOATEDrugbanksmall molecule
DB04779 ETHYL (1E)-2-PHENYL-N-(SULFOOXY)ETHANIMIDOTHIOATEDrugbanksmall molecule
DB08558 2-HYDROXYMETHYL-6-OCTYLSULFANYL-TETRAHYDRO-PYRAN-3,4,5-TRIOLDrugbanksmall molecule

Interactions

3 interactions

InteractorPartnerSourcesPublicationsLink
LPH_HUMANSRC_HUMANMINT17053785 details
LPH_HUMANCALX_HUMANBioGRID, HPRD11751874 details
LPH_HUMANBIP_HUMANBioGRID, HPRD11751874 details