Entity Details

Primary name ARAF_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionP10398
EntryNameARAF_HUMAN
FullNameSerine/threonine-protein kinase A-Raf
TaxID9606
Evidenceevidence at protein level
Length606
SequenceStatuscomplete
DateCreated1988-04-01
DateModified2021-06-02

Ontological Relatives

GenesARAF

GO terms

Show/Hide Table
GOName
GO:0000165 MAPK cascade
GO:0004672 protein kinase activity
GO:0004674 protein serine/threonine kinase activity
GO:0004709 MAP kinase kinase kinase activity
GO:0005524 ATP binding
GO:0005739 mitochondrion
GO:0005829 cytosol
GO:0006464 cellular protein modification process
GO:0032006 regulation of TOR signaling
GO:0032434 regulation of proteasomal ubiquitin-dependent protein catabolic process
GO:0033138 positive regulation of peptidyl-serine phosphorylation
GO:0043066 negative regulation of apoptotic process
GO:0046872 metal ion binding
GO:0106310 protein serine kinase activity
GO:0106311 protein threonine kinase activity

Subcellular Location

Show/Hide Table

Domains

Show/Hide Table
DomainNameCategoryType
IPR000719 Protein kinase domainDomainDomain
IPR001245 Serine-threonine/tyrosine-protein kinase, catalytic domainDomainDomain
IPR002219 Protein kinase C-like, phorbol ester/diacylglycerol-binding domainDomainDomain
IPR003116 Raf-like Ras-bindingDomainDomain
IPR008271 Serine/threonine-protein kinase, active siteSiteActive site
IPR011009 Protein kinase-like domain superfamilyFamilyHomologous superfamily
IPR017441 Protein kinase, ATP binding siteSiteBinding site
IPR020454 Diacylglycerol/phorbol-ester bindingDomainDomain
IPR029071 Ubiquitin-like domain superfamilyFamilyHomologous superfamily

Diseases

Show/Hide Table

Drugs

Show/Hide Table
DrugNameSourceType
DB00171 ATPDrugbanksmall molecule

Interactions

81 interactions

InteractorPartnerSourcesPublicationsLink
ARAF_HUMANP85A_HUMANBioGRID, HPRD, MINT10967104 11812000 details
ARAF_HUMAN1433G_HUMANBioGRID, HPRD, IntAct, MINT15324660 17353931 25852190 28205554 28514442 29777862 31980649 details
ARAF_HUMANPGTB2_HUMANBioGRID, HPRD, IntAct12620389 details
ARAF_HUMANNELFD_HUMANBioGRID, HPRD, IntAct11952167 12620389 14684750 21988832 details
ARAF_HUMANPRP6_HUMANBioGRID, HPRD, IntAct10848612 12620389 details
ARAF_HUMANTIM44_HUMANBioGRID, HPRD, IntAct10848612 12620389 details
ARAF_HUMANASSY_HUMANBioGRID, HPRD, IntAct12620389 details
ARAF_HUMANNUD14_HUMANHPRD, IntAct12620389 details
ARAF_HUMANCSN3_HUMANBioGRID, HPRD, IntAct12620389 details
ARAF_HUMANTOPK_HUMANBioGRID, HPRD, IntAct12620389 details
ARAF_HUMANRRAS2_HUMANBioGRID, HPRD, IntAct12620389 details
ARAF_HUMANTIM50_HUMANBioGRID, IntAct12620389 25852190 29777862 details
ARAF_HUMANFBLN3_HUMANBioGRID, IntAct12620389 details
ARAF_HUMANCPSM_HUMANBioGRID, HPRD, IntAct12620389 details
ARAF_HUMANKPYM_HUMANBioGRID, HPRD, IntAct12620389 25241761 details
ARAF_HUMANRASH_HUMANBioGRID, DIP, HPRD, IntAct12620389 24441586 28205554 details
ARAF_HUMANKLH12_HUMANBioGRID, HPRD, IntAct16189514 details
ARAF_HUMANMP2K2_HUMANBioGRID, HPRD, IntAct11909642 21988832 24746704 25852190 31980649 32296183 details
ARAF_HUMAN1433S_HUMANBioGRID, IntAct, MINT15778465 25852190 28205554 31980649 details
ARAF_HUMANCSK2B_HUMANBioGRID, HPRD, IntAct10094392 9042965 details
ARAF_HUMANBRAF_HUMANBioGRID, DIP, IntAct17979178 20130576 25241761 28205554 28514442 31980649 details
ARAF_HUMANMP2K1_HUMANBioGRID, HPRD, IntAct17979178 24114843 24746704 26496610 31980649 7731720 8157000 8394352 8621729 details
ARAF_HUMAN1433Z_HUMANBioGRID, IntAct, MINT19933840 20052757 20936779 25266655 25852190 28205554 29777862 31980649 details
ARAF_HUMANMLH1_HUMANBioGRID, IntAct20706999 details
ARAF_HUMANCHD6_HUMANBioGRID, IntAct20936779 details
ARAF_HUMAN1433E_HUMANBioGRID, IntAct17979178 19608861 20936779 25852190 29777862 details
ARAF_HUMANMY18A_HUMANBioGRID, IntAct20936779 details
ARAF_HUMANE2F6_HUMANBioGRID, IntAct21988832 details
ARAF_HUMANTESK1_HUMANBioGRID, IntAct21988832 details
ARAF_HUMANDIDO1_HUMANBioGRID, IntAct21988832 details
ARAF_HUMANWNK1_HUMANBioGRID, IntAct21988832 details
ARAF_HUMANIRF7_HUMANBioGRID, IntAct21903422 details
ARAF_HUMANIRAK2_HUMANBioGRID, IntAct21903422 details
ARAF_HUMANTIRAP_HUMANBioGRID, IntAct21903422 details
ARAF_HUMANRASK_HUMANBioGRID, IntAct25416956 25852190 28205554 30194290 34079125 details
ARAF_HUMANRRAS_HUMANBioGRID, HPRD10848612 12620389 details
ARAF_HUMANBAD_HUMANBioGRID19667065 details
ARAF_HUMANGNA12_HUMANBioGRID24114843 details
ARAF_HUMANATRAP_HUMANBioGRID25416956 details
ARAF_HUMANRASN_HUMANBioGRID29777862 30194290 32296183 details
ARAF_HUMANARAF_HUMANBioGRID, HPRD1262038 28205554 29777862 31980649 details
ARAF_HUMANBECN1_HUMANBioGRID28205554 details
ARAF_HUMANCDK4_HUMANBioGRID28205554 details
ARAF_HUMANEPHA2_HUMANBioGRID28205554 details
ARAF_HUMANMP2K3_HUMANBioGRID28205554 details
ARAF_HUMANMYC_HUMANBioGRID28205554 details
ARAF_HUMANRASF1_HUMANBioGRID28205554 details
ARAF_HUMANSTK11_HUMANBioGRID28205554 details
ARAF_HUMANAKT1_HUMANBioGRID28205554 details
ARAF_HUMANCCND2_HUMANBioGRID28205554 details
ARAF_HUMANCDK6_HUMANBioGRID28205554 details
ARAF_HUMANCDN2B_HUMANBioGRID28205554 details
ARAF_HUMANFGFR4_HUMANBioGRID28205554 details
ARAF_HUMANGLIS2_HUMANBioGRID28205554 details
ARAF_HUMANLATS2_HUMANBioGRID28205554 details
ARAF_HUMANMP2K5_HUMANBioGRID28205554 details
ARAF_HUMANMERL_HUMANBioGRID28205554 details
ARAF_HUMANP53_HUMANBioGRID28205554 details
ARAF_HUMANTSC1_HUMANBioGRID28205554 details
ARAF_HUMANPK3CA_HUMANBioGRID28205554 details
ARAF_HUMANRGS12_HUMANHPRD17380122 details
ARAF_HUMAN1433F_HUMANBioGRID, IntAct11969417 17979178 25852190 26496610 28514442 29777862 details
ARAF_HUMANHS90B_HUMANBioGRID, IntAct22939624 25036637 29777862 31980649 details
ARAF_HUMANAIFM1_HUMANBioGRID, IntAct25852190 29777862 details
ARAF_HUMANCBY1_HUMANBioGRID, IntAct27173435 unassigned1312 details
ARAF_HUMANRAB3I_HUMANBioGRID, IntAct27173435 unassigned1312 details
ARAF_HUMANHS90A_HUMANBioGRID, IntAct22939624 29777862 31980649 details
ARAF_HUMANNANOG_HUMANBioGRID30595535 details
ARAF_HUMANITCH_HUMANBioGRID31015455 details
ARAF_HUMANRO52_HUMANBioGRID29777862 details
ARAF_HUMANIRS4_HUMANBioGRID29777862 details
ARAF_HUMANBIP_HUMANBioGRID29777862 details
ARAF_HUMANRUVB1_HUMANBioGRID29777862 details
ARAF_HUMANCDK1_HUMANBioGRID29777862 details
ARAF_HUMANPRS7_HUMANBioGRID29777862 details
ARAF_HUMANPRKDC_HUMANBioGRID29777862 details
ARAF_HUMANNUCL_HUMANBioGRID29777862 details
ARAF_HUMANADT2_HUMANBioGRID29777862 details
ARAF_HUMANPARP1_HUMANBioGRID29777862 details
ARAF_HUMANCRBN_HUMANBioGRID32778845 details
ARAF_HUMANPGFRB_HUMANHPRD15763428 details